(46 nodes) Myeloid leukocyte migration network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC102359313	Uncharacterized protein. (334 aa)
	LOC102355766	Uncharacterized protein. (524 aa)
	CCR7	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. (379 aa)
	JAM3	Junctional adhesion molecule 3. (208 aa)
	SYK	Tyrosine-protein kinase. (616 aa)
	ITGA9	Integrin subunit alpha 9. (480 aa)
	LOC102346566	Annexin. (343 aa)
	TNFSF11	TNF superfamily member 11; Belongs to the tumor necrosis factor family. (169 aa)
	H3AGL7_LATCH	G_PROTEIN_RECEP_F1_2 domain-containing protein. (305 aa)
	LOC102358221	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (439 aa)
	LOC102348541	Chemokine (C-X-C motif) receptor 1; Belongs to the G-protein coupled receptor 1 family. (353 aa)
	PIKFYVE	Phosphoinositide kinase, FYVE-type zinc finger containing. (2113 aa)
	BSG	Basigin (Ok blood group). (368 aa)
	LOC102348280	Chemokine (C-X-C motif) receptor 2; Belongs to the G-protein coupled receptor 1 family. (358 aa)
	CXADR	CXADR Ig-like cell adhesion molecule. (297 aa)
	NUP85	Nuclear pore complex protein Nup85; Functions as a component of the nuclear pore complex (NPC). (656 aa)
	KIT	KIT proto-oncogene, receptor tyrosine kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (937 aa)
	PDGFB	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (209 aa)
	H2ZZB2_LATCH	ZP domain-containing protein. (438 aa)
	ITGA1	Integrin subunit alpha 1; Belongs to the integrin alpha chain family. (1185 aa)
	ROR2	Receptor tyrosine kinase like orphan receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (882 aa)
	SCG2	Secretogranin II. (621 aa)
	PTPRO	Protein tyrosine phosphatase receptor type O. (1222 aa)
	H2ZU28_LATCH	SEFIR domain-containing protein. (634 aa)
	LOC102366874	Chemokine (C-X-C motif) receptor 3, tandem duplicate 2; Belongs to the G-protein coupled receptor 1 family. (395 aa)
	PPIB	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (224 aa)
	JAGN1	Jagunal homolog 1. (183 aa)
	TAFA4	TAFA chemokine like family member 4. (95 aa)
	H3B5Z8_LATCH	Uncharacterized protein. (606 aa)
	LOC102354417	Uncharacterized protein. (723 aa)
	GBF1	Golgi brefeldin A resistant guanine nucleotide exchange factor 1. (1912 aa)
	MCOLN2	Mucolipin 2. (538 aa)
	IRAK4	Interleukin 1 receptor associated kinase 4. (454 aa)
	H3B9K7_LATCH	SEFIR domain-containing protein. (774 aa)
	NF1	Neurofibromin 1. (2814 aa)
	FLT1	Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1337 aa)
	LOC102354752	VPS9 domain-containing protein. (197 aa)
	SRP54	Signal recognition particle 54 kDa protein; Binds to the signal sequence of presecretory protein when they emerge from the ribosomes and transfers them to TRAM (translocating chain-associating membrane protein). Belongs to the GTP-binding SRP family. SRP54 subfamily. (504 aa)
	CSF3R	Colony stimulating factor 3 receptor. (826 aa)
	RABGEF1	RAB guanine nucleotide exchange factor (GEF) 1. (532 aa)
	LOC102351798	Galectin. (167 aa)
	LGALS3	Galectin. (274 aa)
	LOC102352351	C-C motif chemokine. (88 aa)
	SLC37A4	Solute carrier family 37 member 4. (441 aa)
	EDNRB	Endothelin receptor type B; Belongs to the G-protein coupled receptor 1 family. (440 aa)
	H3AYQ4_LATCH	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1220 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CCR7	H3AGL7_LATCH	ENSLACP00000015163	ENSLACP00000008788	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	G_PROTEIN_RECEP_F1_2 domain-containing protein.	0.500
CCR7	LOC102348280	ENSLACP00000015163	ENSLACP00000005451	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	Chemokine (C-X-C motif) receptor 2; Belongs to the G-protein coupled receptor 1 family.	0.516
CCR7	LOC102348541	ENSLACP00000015163	ENSLACP00000006086	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	Chemokine (C-X-C motif) receptor 1; Belongs to the G-protein coupled receptor 1 family.	0.629
CCR7	LOC102352351	ENSLACP00000015163	ENSLACP00000021910	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	C-C motif chemokine.	0.753
CSF3R	KIT	ENSLACP00000021140	ENSLACP00000004383	Colony stimulating factor 3 receptor.	KIT proto-oncogene, receptor tyrosine kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.411
CSF3R	SYK	ENSLACP00000021140	ENSLACP00000012982	Colony stimulating factor 3 receptor.	Tyrosine-protein kinase.	0.577
EDNRB	KIT	ENSLACP00000014962	ENSLACP00000004383	Endothelin receptor type B; Belongs to the G-protein coupled receptor 1 family.	KIT proto-oncogene, receptor tyrosine kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.423
EDNRB	LOC102358221	ENSLACP00000014962	ENSLACP00000008101	Endothelin receptor type B; Belongs to the G-protein coupled receptor 1 family.	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	0.901
FLT1	PDGFB	ENSLACP00000019807	ENSLACP00000002907	Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family.	0.924
H2ZU28_LATCH	H3B9K7_LATCH	ENSLACP00000000899	ENSLACP00000018578	SEFIR domain-containing protein.	SEFIR domain-containing protein.	0.884
H3AGL7_LATCH	CCR7	ENSLACP00000008788	ENSLACP00000015163	G_PROTEIN_RECEP_F1_2 domain-containing protein.	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family.	0.500
H3AGL7_LATCH	LOC102348280	ENSLACP00000008788	ENSLACP00000005451	G_PROTEIN_RECEP_F1_2 domain-containing protein.	Chemokine (C-X-C motif) receptor 2; Belongs to the G-protein coupled receptor 1 family.	0.900
H3AGL7_LATCH	LOC102348541	ENSLACP00000008788	ENSLACP00000006086	G_PROTEIN_RECEP_F1_2 domain-containing protein.	Chemokine (C-X-C motif) receptor 1; Belongs to the G-protein coupled receptor 1 family.	0.900
H3AGL7_LATCH	LOC102352351	ENSLACP00000008788	ENSLACP00000021910	G_PROTEIN_RECEP_F1_2 domain-containing protein.	C-C motif chemokine.	0.734
H3AYQ4_LATCH	PDGFB	ENSLACP00000014775	ENSLACP00000002907	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family.	0.733
H3B9K7_LATCH	H2ZU28_LATCH	ENSLACP00000018578	ENSLACP00000000899	SEFIR domain-containing protein.	SEFIR domain-containing protein.	0.884
ITGA1	ITGA9	ENSLACP00000002052	ENSLACP00000015961	Integrin subunit alpha 1; Belongs to the integrin alpha chain family.	Integrin subunit alpha 9.	0.557
ITGA9	ITGA1	ENSLACP00000015961	ENSLACP00000002052	Integrin subunit alpha 9.	Integrin subunit alpha 1; Belongs to the integrin alpha chain family.	0.557
ITGA9	JAM3	ENSLACP00000015961	ENSLACP00000013392	Integrin subunit alpha 9.	Junctional adhesion molecule 3.	0.600
JAGN1	SLC37A4	ENSLACP00000017119	ENSLACP00000023305	Jagunal homolog 1.	Solute carrier family 37 member 4.	0.422