(85 nodes) Photoreceptor cell cilium network (Latimeria chalumnae)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	BBS7	Bardet-Biedl syndrome 7 protein homolog; The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. (715 aa)
	H2ZZF8_LATCH	Recoverin 3. (164 aa)
	SAG	S-antigen visual arrestin. (317 aa)
	CIB2	Calcium and integrin binding family member 2. (161 aa)
	CEP290	Centrosomal protein 290. (2474 aa)
	LOC102349946	G_PROTEIN_RECEP_F1_2 domain-containing protein. (361 aa)
	TOPORS	TOP1 binding arginine/serine rich protein. (1037 aa)
	H3A478_LATCH	PDZ domain-containing protein. (297 aa)
	H3A4S8_LATCH	Uncharacterized protein. (2030 aa)
	PHLPP2	PH domain and leucine rich repeat protein phosphatase 2. (1186 aa)
	GNAT3	G protein subunit alpha transducin 3. (355 aa)
	SHANK2	SH3 and multiple ankyrin repeat domains 2. (1161 aa)
	LOC102361323	Peripherin 2-like a. (364 aa)
	CCDC66	Coiled-coil domain containing 66. (966 aa)
	GUCY2F	Guanylate cyclase. (1115 aa)
	H3A7M4_LATCH	Phosphodiesterase. (663 aa)
	BSG	Basigin (Ok blood group). (368 aa)
	CETN3	Centrin 3. (167 aa)
	KIFAP3	Kinesin associated protein 3. (795 aa)
	CNGA1	Cyclic nucleotide gated channel subunit alpha 1. (542 aa)
	RPGRIP1	RPGR interacting protein 1. (1244 aa)
	SPATA7	Spermatogenesis associated 7. (398 aa)
	CNGB1	Cyclic nucleotide gated channel subunit beta 1. (726 aa)
	CRB1	Crumbs cell polarity complex component 1. (1366 aa)
	RP1L1	Uncharacterized protein. (1547 aa)
	GUCA1A	Guanylate cyclase activator 1A. (202 aa)
	IMPG1	Interphotoreceptor matrix proteoglycan 1. (689 aa)
	IQCB1	IQ motif containing B1. (601 aa)
	H3AIG1_LATCH	Uncharacterized protein. (317 aa)
	CNGB3	Cyclic nucleotide gated channel subunit beta 3. (449 aa)
	OPN3	Opsin 3; Belongs to the G-protein coupled receptor 1 family. (155 aa)
	H3ALJ8_LATCH	PDEase domain-containing protein. (155 aa)
	MERTK	MER proto-oncogene, tyrosine kinase. (897 aa)
	OCRL	OCRL inositol polyphosphate-5-phosphatase. (815 aa)
	H3AN88_LATCH	Uncharacterized protein. (780 aa)
	RGS9BP	Regulator of G protein signaling 9 binding protein. (237 aa)
	USH1G	USH1 protein network component sans. (471 aa)
	LOC102349202	Vertebrate ancient long opsin b. (322 aa)
	FAM161A	FAM161 centrosomal protein A. (680 aa)
	LCA5	Lebercilin LCA5. (743 aa)
	RPGRIP1L	RPGRIP1 like. (1318 aa)
	TTC8	Tetratricopeptide repeat domain 8. (534 aa)
	LYAR	Ly1 antibody reactive. (403 aa)
	NPHP4	Nephrocystin 4. (1207 aa)
	IFT52	Intraflagellar transport 52. (440 aa)
	CRB2	Uncharacterized protein. (1473 aa)
	GUCA1B	Uncharacterized protein. (197 aa)
	FAM161B	FAM161 centrosomal protein B. (710 aa)
	IFT20	Intraflagellar transport 20. (132 aa)
	KIF17	Kinesin family member 17; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1042 aa)
	GNAT2	G protein subunit alpha transducin 2. (333 aa)
	TBCC	Tubulin folding cofactor C. (348 aa)
	NXNL1	Nucleoredoxin like 1. (221 aa)
	PDE6G	Phosphodiesterase 6G. (101 aa)
	GUCA1C	Guanylate cyclase activator 1C. (191 aa)
	LOC102347432	Rhodopsin. (355 aa)
	RPGR	Retinitis pigmentosa GTPase regulator. (1152 aa)
	H3B6I2_LATCH	Uncharacterized protein. (305 aa)
	VCAN	Uncharacterized protein. (376 aa)
	H3B4C9_LATCH	PDZ domain-containing protein. (105 aa)
	RP1	RP1 axonemal microtubule associated. (1901 aa)
	CFAP410	Cilia and flagella associated protein 410. (253 aa)
	SDCCAG8	Serologically defined colon cancer antigen 8. (726 aa)
	CDHR1	Cadherin related family member 1. (688 aa)
	CERKL	Ceramide kinase like. (458 aa)
	PCARE	Photoreceptor cilium actin regulator. (1283 aa)
	RGR	Retinal G protein coupled receptor; Belongs to the G-protein coupled receptor 1 family. Opsin subfamily. (295 aa)
	RHO	Rhodopsin. (355 aa)
	RD3	Retinal degeneration 3, GUCY2D regulator. (197 aa)
	PRPH2	Peripherin 2. (350 aa)
	MAGI2	Uncharacterized protein. (397 aa)
	PDE6A	Phosphodiesterase. (862 aa)
	IFT57	Intraflagellar transport 57. (428 aa)
	LOC102350991	Uncharacterized protein. (1471 aa)
	LOC102357108	Opsin 1 (cone pigments), short-wave-sensitive 2. (360 aa)
	GNAT1	G protein subunit alpha transducin 1. (321 aa)
	GUCY2D	Guanylate cyclase. (1026 aa)
	H2ZS04_LATCH	Guanylate cyclase. (828 aa)
	IFT140	Intraflagellar transport 140. (1471 aa)
	WDR19	WD repeat domain 19. (895 aa)
	LOC102364679	Centrin 4. (174 aa)
	ARL3	ADP ribosylation factor like GTPase 3; Belongs to the small GTPase superfamily. Arf family. (203 aa)
	H2ZX26_LATCH	Uncharacterized protein. (412 aa)
	BBS4	Bardet-Biedl syndrome 4. (537 aa)
	RRH	Retinal pigment epithelium-derived rhodopsin homolog; Belongs to the G-protein coupled receptor 1 family. (383 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARL3	BBS7	ENSLACP00000001788	ENSLACP00000002676	ADP ribosylation factor like GTPase 3; Belongs to the small GTPase superfamily. Arf family.	Bardet-Biedl syndrome 7 protein homolog; The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function.	0.558
ARL3	IFT20	ENSLACP00000001788	ENSLACP00000020475	ADP ribosylation factor like GTPase 3; Belongs to the small GTPase superfamily. Arf family.	Intraflagellar transport 20.	0.718
ARL3	IFT57	ENSLACP00000001788	ENSLACP00000013629	ADP ribosylation factor like GTPase 3; Belongs to the small GTPase superfamily. Arf family.	Intraflagellar transport 57.	0.633
ARL3	IQCB1	ENSLACP00000001788	ENSLACP00000009378	ADP ribosylation factor like GTPase 3; Belongs to the small GTPase superfamily. Arf family.	IQ motif containing B1.	0.408
ARL3	KIF17	ENSLACP00000001788	ENSLACP00000020454	ADP ribosylation factor like GTPase 3; Belongs to the small GTPase superfamily. Arf family.	Kinesin family member 17; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.441
ARL3	NPHP4	ENSLACP00000001788	ENSLACP00000021760	ADP ribosylation factor like GTPase 3; Belongs to the small GTPase superfamily. Arf family.	Nephrocystin 4.	0.524
ARL3	RPGR	ENSLACP00000001788	ENSLACP00000017597	ADP ribosylation factor like GTPase 3; Belongs to the small GTPase superfamily. Arf family.	Retinitis pigmentosa GTPase regulator.	0.405
ARL3	RPGRIP1L	ENSLACP00000001788	ENSLACP00000022895	ADP ribosylation factor like GTPase 3; Belongs to the small GTPase superfamily. Arf family.	RPGRIP1 like.	0.492
ARL3	TBCC	ENSLACP00000001788	ENSLACP00000020092	ADP ribosylation factor like GTPase 3; Belongs to the small GTPase superfamily. Arf family.	Tubulin folding cofactor C.	0.895
BBS4	BBS7	ENSLACP00000002102	ENSLACP00000002676	Bardet-Biedl syndrome 4.	Bardet-Biedl syndrome 7 protein homolog; The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function.	0.997
BBS4	CEP290	ENSLACP00000002102	ENSLACP00000003693	Bardet-Biedl syndrome 4.	Centrosomal protein 290.	0.660
BBS4	IFT140	ENSLACP00000002102	ENSLACP00000000383	Bardet-Biedl syndrome 4.	Intraflagellar transport 140.	0.616
BBS4	IFT20	ENSLACP00000002102	ENSLACP00000020475	Bardet-Biedl syndrome 4.	Intraflagellar transport 20.	0.828
BBS4	IFT52	ENSLACP00000002102	ENSLACP00000021626	Bardet-Biedl syndrome 4.	Intraflagellar transport 52.	0.671
BBS4	IFT57	ENSLACP00000002102	ENSLACP00000013629	Bardet-Biedl syndrome 4.	Intraflagellar transport 57.	0.719
BBS4	NPHP4	ENSLACP00000002102	ENSLACP00000021760	Bardet-Biedl syndrome 4.	Nephrocystin 4.	0.470
BBS4	RPGRIP1L	ENSLACP00000002102	ENSLACP00000022895	Bardet-Biedl syndrome 4.	RPGRIP1 like.	0.475
BBS4	TTC8	ENSLACP00000002102	ENSLACP00000022744	Bardet-Biedl syndrome 4.	Tetratricopeptide repeat domain 8.	0.997
BBS7	ARL3	ENSLACP00000002676	ENSLACP00000001788	Bardet-Biedl syndrome 7 protein homolog; The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function.	ADP ribosylation factor like GTPase 3; Belongs to the small GTPase superfamily. Arf family.	0.558
BBS7	BBS4	ENSLACP00000002676	ENSLACP00000002102	Bardet-Biedl syndrome 7 protein homolog; The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function.	Bardet-Biedl syndrome 4.	0.997