(23 nodes) Cellular response to virus network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	VWCE	Von Willebrand factor C and EGF domains. (620 aa)
	DHX58	DExH-box helicase 58. (680 aa)
	TLR3	Toll like receptor 3; Belongs to the Toll-like receptor family. (766 aa)
	IFIH1	Interferon induced with helicase C domain 1. (731 aa)
	MAPK11	Mitogen-activated protein kinase. (361 aa)
	GBF1	Golgi brefeldin A resistant guanine nucleotide exchange factor 1. (1912 aa)
	IRF3	Interferon regulatory factor 3. (481 aa)
	RIOK3	Serine/threonine-protein kinase RIO3; Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family. (513 aa)
	LOC102346889	Uncharacterized protein. (744 aa)
	ZC3H12A	Zinc finger CCCH-type containing 12A. (600 aa)
	LSM14A	LSM14A mRNA processing body assembly factor. (483 aa)
	DDX58	DExD/H-box helicase 58. (944 aa)
	MAPK14	Mitogen-activated protein kinase. (399 aa)
	WDFY4	Uncharacterized protein. (932 aa)
	TOMM70	Translocase of outer mitochondrial membrane 70. (601 aa)
	H3AB29_LATCH	Uncharacterized protein. (1804 aa)
	PHB	Prohibitin. (272 aa)
	BAX	Uncharacterized protein. (223 aa)
	GSDME	Uncharacterized protein. (491 aa)
	CLPB	ClpB homolog, mitochondrial AAA ATPase chaperonin. (425 aa)
	LOC102358504	SCY domain-containing protein. (118 aa)
	ADAR	Adenosine deaminase RNA specific. (1150 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (401 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADAR	DHX58	ENSLACP00000021926	ENSLACP00000012725	Adenosine deaminase RNA specific.	DExH-box helicase 58.	0.429
ADAR	IFIH1	ENSLACP00000021926	ENSLACP00000012995	Adenosine deaminase RNA specific.	Interferon induced with helicase C domain 1.	0.574
BAX	IRF3	ENSLACP00000007049	ENSLACP00000019335	Uncharacterized protein.	Interferon regulatory factor 3.	0.496
CLPB	PHB	ENSLACP00000009565	ENSLACP00000006862	ClpB homolog, mitochondrial AAA ATPase chaperonin.	Prohibitin.	0.411
DDX58	IRF3	ENSLACP00000000461	ENSLACP00000019335	DExD/H-box helicase 58.	Interferon regulatory factor 3.	0.415
DDX58	WDFY4	ENSLACP00000000461	ENSLACP00000005464	DExD/H-box helicase 58.	Uncharacterized protein.	0.516
DHX58	ADAR	ENSLACP00000012725	ENSLACP00000021926	DExH-box helicase 58.	Adenosine deaminase RNA specific.	0.429
DHX58	IFIH1	ENSLACP00000012725	ENSLACP00000012995	DExH-box helicase 58.	Interferon induced with helicase C domain 1.	0.836
DHX58	IRF3	ENSLACP00000012725	ENSLACP00000019335	DExH-box helicase 58.	Interferon regulatory factor 3.	0.654
DHX58	TLR3	ENSLACP00000012725	ENSLACP00000012956	DExH-box helicase 58.	Toll like receptor 3; Belongs to the Toll-like receptor family.	0.548
H3AB29_LATCH	WDFY4	ENSLACP00000006850	ENSLACP00000005464	Uncharacterized protein.	Uncharacterized protein.	0.935
IFIH1	ADAR	ENSLACP00000012995	ENSLACP00000021926	Interferon induced with helicase C domain 1.	Adenosine deaminase RNA specific.	0.574
IFIH1	DHX58	ENSLACP00000012995	ENSLACP00000012725	Interferon induced with helicase C domain 1.	DExH-box helicase 58.	0.836
IFIH1	IRF3	ENSLACP00000012995	ENSLACP00000019335	Interferon induced with helicase C domain 1.	Interferon regulatory factor 3.	0.805
IFIH1	TLR3	ENSLACP00000012995	ENSLACP00000012956	Interferon induced with helicase C domain 1.	Toll like receptor 3; Belongs to the Toll-like receptor family.	0.757
IRF3	BAX	ENSLACP00000019335	ENSLACP00000007049	Interferon regulatory factor 3.	Uncharacterized protein.	0.496
IRF3	DDX58	ENSLACP00000019335	ENSLACP00000000461	Interferon regulatory factor 3.	DExD/H-box helicase 58.	0.415
IRF3	DHX58	ENSLACP00000019335	ENSLACP00000012725	Interferon regulatory factor 3.	DExH-box helicase 58.	0.654
IRF3	IFIH1	ENSLACP00000019335	ENSLACP00000012995	Interferon regulatory factor 3.	Interferon induced with helicase C domain 1.	0.805
IRF3	TLR3	ENSLACP00000019335	ENSLACP00000012956	Interferon regulatory factor 3.	Toll like receptor 3; Belongs to the Toll-like receptor family.	0.878