(43 nodes) Protein complex involved in cell adhesion network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LAMB2	Laminin subunit beta 2. (1781 aa)
	ITGB6	Integrin beta; Belongs to the integrin beta chain family. (675 aa)
	ITGAV	Integrin_alpha2 domain-containing protein. (597 aa)
	TNR	Tenascin R. (992 aa)
	LOC102346778	Uncharacterized protein. (175 aa)
	ITGB1	Integrin beta; Belongs to the integrin beta chain family. (822 aa)
	ITGB8	Integrin beta; Belongs to the integrin beta chain family. (637 aa)
	ITGA1	Integrin subunit alpha 1; Belongs to the integrin alpha chain family. (1185 aa)
	H3A0Z4_LATCH	VWFA domain-containing protein; Belongs to the integrin alpha chain family. (1149 aa)
	TNC	Tenascin C. (2213 aa)
	LOC102349081	Integrin beta; Belongs to the integrin beta chain family. (570 aa)
	ITGA3	Integrin subunit alpha 3; Belongs to the integrin alpha chain family. (1012 aa)
	ITGA8	Integrin subunit alpha 8; Belongs to the integrin alpha chain family. (1048 aa)
	ITGA6	Integrin subunit alpha 6; Belongs to the integrin alpha chain family. (1077 aa)
	ITGAE	VWFA domain-containing protein; Belongs to the integrin alpha chain family. (760 aa)
	LYN	Tyrosine-protein kinase. (515 aa)
	JAM2	Junctional adhesion molecule 2. (292 aa)
	LGALS2	Galectin. (137 aa)
	TSPAN32	Uncharacterized protein. (146 aa)
	TNN	Tenascin N. (831 aa)
	CTLA4	IG domain-containing protein. (186 aa)
	H3AM01_LATCH	Integrin beta; Belongs to the integrin beta chain family. (769 aa)
	CD28	Ig-like domain-containing protein. (202 aa)
	PLAU	Uncharacterized protein. (469 aa)
	EMILIN1	Elastin microfibril interfacer 1. (1047 aa)
	MMRN1	Multimerin 1. (914 aa)
	LOC102351091	VWFA domain-containing protein; Belongs to the integrin alpha chain family. (1163 aa)
	JAM3	Junctional adhesion molecule 3. (208 aa)
	H3AVI2_LATCH	VWFA domain-containing protein; Belongs to the integrin alpha chain family. (958 aa)
	ITGB4	Integrin beta. (1787 aa)
	ITGA2	Integrin subunit alpha 2; Belongs to the integrin alpha chain family. (1129 aa)
	ITGA9	Integrin subunit alpha 9. (480 aa)
	H3B2K2_LATCH	VWFA domain-containing protein; Belongs to the integrin alpha chain family. (1136 aa)
	ITGA4	Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (1037 aa)
	ITGB5	Integrin beta; Belongs to the integrin beta chain family. (697 aa)
	ITGA11	Integrin subunit alpha 11; Belongs to the integrin alpha chain family. (1136 aa)
	ITGB7	Integrin beta; Belongs to the integrin beta chain family. (778 aa)
	ITGA7	Integrin subunit alpha 7; Belongs to the integrin alpha chain family. (1029 aa)
	H3BAT8_LATCH	Uncharacterized protein. (156 aa)
	ITGB2	Integrin beta. (776 aa)
	ITGA10	Integrin subunit alpha 10; Belongs to the integrin alpha chain family. (1177 aa)
	VTN	Vitronectin b. (492 aa)
	LOC106706381	Uncharacterized protein. (224 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CD28	CTLA4	ENSLACP00000010862	ENSLACP00000010132	Ig-like domain-containing protein.	IG domain-containing protein.	0.744
CTLA4	CD28	ENSLACP00000010132	ENSLACP00000010862	IG domain-containing protein.	Ig-like domain-containing protein.	0.744
CTLA4	LYN	ENSLACP00000010132	ENSLACP00000006462	IG domain-containing protein.	Tyrosine-protein kinase.	0.532
H3A0Z4_LATCH	H3AM01_LATCH	ENSLACP00000003315	ENSLACP00000010672	VWFA domain-containing protein; Belongs to the integrin alpha chain family.	Integrin beta; Belongs to the integrin beta chain family.	0.670
H3A0Z4_LATCH	ITGA1	ENSLACP00000003315	ENSLACP00000002052	VWFA domain-containing protein; Belongs to the integrin alpha chain family.	Integrin subunit alpha 1; Belongs to the integrin alpha chain family.	0.478
H3A0Z4_LATCH	ITGA10	ENSLACP00000003315	ENSLACP00000019945	VWFA domain-containing protein; Belongs to the integrin alpha chain family.	Integrin subunit alpha 10; Belongs to the integrin alpha chain family.	0.478
H3A0Z4_LATCH	ITGA11	ENSLACP00000003315	ENSLACP00000017703	VWFA domain-containing protein; Belongs to the integrin alpha chain family.	Integrin subunit alpha 11; Belongs to the integrin alpha chain family.	0.478
H3A0Z4_LATCH	ITGA2	ENSLACP00000003315	ENSLACP00000015364	VWFA domain-containing protein; Belongs to the integrin alpha chain family.	Integrin subunit alpha 2; Belongs to the integrin alpha chain family.	0.478
H3A0Z4_LATCH	ITGA3	ENSLACP00000003315	ENSLACP00000004591	VWFA domain-containing protein; Belongs to the integrin alpha chain family.	Integrin subunit alpha 3; Belongs to the integrin alpha chain family.	0.468
H3A0Z4_LATCH	ITGA4	ENSLACP00000003315	ENSLACP00000016373	VWFA domain-containing protein; Belongs to the integrin alpha chain family.	Integrin subunit alpha 4; Belongs to the integrin alpha chain family.	0.587
H3A0Z4_LATCH	ITGA6	ENSLACP00000003315	ENSLACP00000005786	VWFA domain-containing protein; Belongs to the integrin alpha chain family.	Integrin subunit alpha 6; Belongs to the integrin alpha chain family.	0.511
H3A0Z4_LATCH	ITGA7	ENSLACP00000003315	ENSLACP00000018756	VWFA domain-containing protein; Belongs to the integrin alpha chain family.	Integrin subunit alpha 7; Belongs to the integrin alpha chain family.	0.511
H3A0Z4_LATCH	ITGA8	ENSLACP00000003315	ENSLACP00000005695	VWFA domain-containing protein; Belongs to the integrin alpha chain family.	Integrin subunit alpha 8; Belongs to the integrin alpha chain family.	0.591
H3A0Z4_LATCH	ITGA9	ENSLACP00000003315	ENSLACP00000015961	VWFA domain-containing protein; Belongs to the integrin alpha chain family.	Integrin subunit alpha 9.	0.584
H3A0Z4_LATCH	ITGAV	ENSLACP00000003315	ENSLACP00000000513	VWFA domain-containing protein; Belongs to the integrin alpha chain family.	Integrin_alpha2 domain-containing protein.	0.553
H3A0Z4_LATCH	ITGB1	ENSLACP00000003315	ENSLACP00000001191	VWFA domain-containing protein; Belongs to the integrin alpha chain family.	Integrin beta; Belongs to the integrin beta chain family.	0.714
H3A0Z4_LATCH	ITGB2	ENSLACP00000003315	ENSLACP00000019456	VWFA domain-containing protein; Belongs to the integrin alpha chain family.	Integrin beta.	0.714
H3A0Z4_LATCH	ITGB4	ENSLACP00000003315	ENSLACP00000014997	VWFA domain-containing protein; Belongs to the integrin alpha chain family.	Integrin beta.	0.624
H3A0Z4_LATCH	ITGB5	ENSLACP00000003315	ENSLACP00000017410	VWFA domain-containing protein; Belongs to the integrin alpha chain family.	Integrin beta; Belongs to the integrin beta chain family.	0.652
H3A0Z4_LATCH	ITGB6	ENSLACP00000003315	ENSLACP00000000457	VWFA domain-containing protein; Belongs to the integrin alpha chain family.	Integrin beta; Belongs to the integrin beta chain family.	0.652