(20 nodes) Positive regulation of animal organ morphogenesis network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	HOXC11	Homeobox C11. (301 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (401 aa)
	CD34	Uncharacterized protein. (378 aa)
	BMP4	Bone morphogenetic protein 4. (460 aa)
	LOC102356247	Uncharacterized protein. (636 aa)
	BMP2	Bone morphogenetic protein 2. (402 aa)
	FGF1	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
	HOXD11	Homeobox D11. (294 aa)
	LOC102351081	Bone morphogenetic protein 16. (396 aa)
	FGF8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
	FRS2	Fibroblast growth factor receptor substrate 2. (502 aa)
	GDNF	Glial cell derived neurotrophic factor. (222 aa)
	LOC102358266	Dickkopf WNT signaling pathway inhibitor 1b. (261 aa)
	GATA3	GATA binding protein 3. (447 aa)
	WNT2B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
	SOX8	SRY-box transcription factor 8. (477 aa)
	WNT2	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (358 aa)
	SPRY1	Sprouty RTK signaling antagonist 1. (320 aa)
	CTNNB1	Catenin beta 1. (781 aa)
	AR	Androgen receptor. (412 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AR	CTNNB1	ENSLACP00000017054	ENSLACP00000017209	Androgen receptor.	Catenin beta 1.	0.933
BMP2	BMP4	ENSLACP00000016168	ENSLACP00000021723	Bone morphogenetic protein 2.	Bone morphogenetic protein 4.	0.903
BMP2	FGF1	ENSLACP00000016168	ENSLACP00000015106	Bone morphogenetic protein 2.	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	0.401
BMP2	FGF8	ENSLACP00000016168	ENSLACP00000007843	Bone morphogenetic protein 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.421
BMP4	BMP2	ENSLACP00000021723	ENSLACP00000016168	Bone morphogenetic protein 4.	Bone morphogenetic protein 2.	0.903
BMP4	FGF1	ENSLACP00000021723	ENSLACP00000015106	Bone morphogenetic protein 4.	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	0.499
BMP4	FGF8	ENSLACP00000021723	ENSLACP00000007843	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.642
CD34	TGFB1	ENSLACP00000021425	ENSLACP00000020652	Uncharacterized protein.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.468
CTNNB1	AR	ENSLACP00000017209	ENSLACP00000017054	Catenin beta 1.	Androgen receptor.	0.933
CTNNB1	FGF8	ENSLACP00000017209	ENSLACP00000007843	Catenin beta 1.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.437
CTNNB1	LOC102358266	ENSLACP00000017209	ENSLACP00000005525	Catenin beta 1.	Dickkopf WNT signaling pathway inhibitor 1b.	0.652
CTNNB1	SOX8	ENSLACP00000017209	ENSLACP00000018883	Catenin beta 1.	SRY-box transcription factor 8.	0.701
CTNNB1	TGFB1	ENSLACP00000017209	ENSLACP00000020652	Catenin beta 1.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.540
CTNNB1	WNT2	ENSLACP00000017209	ENSLACP00000017997	Catenin beta 1.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.589
CTNNB1	WNT2B	ENSLACP00000017209	ENSLACP00000020566	Catenin beta 1.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.589
FGF1	BMP2	ENSLACP00000015106	ENSLACP00000016168	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	Bone morphogenetic protein 2.	0.401
FGF1	BMP4	ENSLACP00000015106	ENSLACP00000021723	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	Bone morphogenetic protein 4.	0.499
FGF1	FGF8	ENSLACP00000015106	ENSLACP00000007843	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.581
FGF1	FRS2	ENSLACP00000015106	ENSLACP00000007102	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	Fibroblast growth factor receptor substrate 2.	0.631
FGF1	TGFB1	ENSLACP00000015106	ENSLACP00000020652	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	Transforming growth factor beta; Belongs to the TGF-beta family.	0.563