(78 nodes) Regulation of cold-induced thermogenesis network (Latimeria chalumnae)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	H2ZSX8_LATCH	Fibronectin type-III domain-containing protein. (243 aa)
	PDGFC	Platelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (243 aa)
	ELOVL6	Elongation of very long chain fatty acids protein 6; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that elongates fatty acids with 12, 14 and 16 carbons with higher activity toward C16:0 acyl-CoAs. Catalyzes the synthesis of unsaturated C16 long chain fatty acids and, to a lesser extent, C18:0 and those with low desaturation degre [...] (265 aa)
	LOC102350151	Uncharacterized protein. (383 aa)
	DHRS7B	Dehydrogenase/reductase 7B; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (323 aa)
	IL18	Uncharacterized protein. (200 aa)
	PRDM16	PR/SET domain 16. (1135 aa)
	PRDM16-2	Si:ch211-263k4.2. (114 aa)
	NR1H3	Nuclear receptor subfamily 1 group H member 3. (375 aa)
	DDIT3	DNA damage inducible transcript 3. (256 aa)
	G0S2	G0/G1 switch 2. (100 aa)
	LOC102350837	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (361 aa)
	CAV3	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (153 aa)
	LOC102354477	Uncharacterized protein. (838 aa)
	ADIPOR2	Adiponectin receptor 2. (372 aa)
	PGAM5	PGAM family member 5, mitochondrial serine/threonine protein phosphatase. (293 aa)
	BSCL2	BSCL2 lipid droplet biogenesis associated, seipin. (290 aa)
	DIO2	Iodothyronine deiodinase; Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine). (130 aa)
	H3BB14_LATCH	Uncharacterized protein. (123 aa)
	HOXC10	Homeobox C10. (339 aa)
	TSHR	Thyrotropin receptor; Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism. Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (689 aa)
	NR1H2	Nuclear receptor subfamily 1 group H member 2. (426 aa)
	LAMA4	Laminin subunit alpha 4. (1721 aa)
	SLC25A44	Solute carrier family 25 member 44; Belongs to the mitochondrial carrier (TC 2.A.29) family. (314 aa)
	PPARGC1A	PPARG coactivator 1 alpha. (783 aa)
	GHRL	Motilin_assoc domain-containing protein. (110 aa)
	DYNC1H1	Dynein cytoplasmic 1 heavy chain 1. (4615 aa)
	LOC102356748	Formyl peptide receptor 1. (368 aa)
	ABHD6	Abhydrolase domain containing 6. (294 aa)
	ADAMTS5	ADAM metallopeptidase with thrombospondin type 1 motif 5. (519 aa)
	LPIN1	Lipin 1. (938 aa)
	OGT	O-linked N-acetylglucosamine (GlcNAc) transferase. (1048 aa)
	ZNF423	Zinc finger protein 423. (1277 aa)
	LGR4	Leucine rich repeat containing G protein-coupled receptor 4. (955 aa)
	ADIPOR1	Adiponectin receptor 1. (377 aa)
	STK11	Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (442 aa)
	SYK	Tyrosine-protein kinase. (616 aa)
	PPARGC1B	PPARG coactivator 1 beta. (986 aa)
	ADRB1	Adrenoceptor beta 1. (394 aa)
	LEP	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family. (169 aa)
	NR1D1	Nuclear receptor subfamily 1 group D member 1. (614 aa)
	CNOT3	CCR4-NOT transcription complex subunit 3. (727 aa)
	FLCN	Folliculin. (576 aa)
	DECR1	2,4-dienoyl-CoA reductase 1. (326 aa)
	ACOT13	Acyl-CoA thioesterase 13. (157 aa)
	IL18R1	TIR domain-containing protein. (153 aa)
	SIRT6	Sirtuin 6. (375 aa)
	H3AGM7_LATCH	Fibronectin type-III domain-containing protein. (234 aa)
	LEPR	Leptin receptor. (1149 aa)
	HCRT	Hypocretin neuropeptide precursor. (104 aa)
	ID1	Inhibitor of DNA binding 1, HLH protein. (131 aa)
	FH	Fumarate hydratase. (491 aa)
	KDM1A	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (820 aa)
	IP6K1	Kinase; Belongs to the inositol phosphokinase (IPK) family. (428 aa)
	KDM6B	Lysine demethylase 6B. (1638 aa)
	NPR3	Natriuretic peptide receptor 3. (483 aa)
	DBH	Dopamine beta-hydroxylase. (617 aa)
	MFN2	Mitofusin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (757 aa)
	LOC102358168	G_PROTEIN_RECEP_F1_2 domain-containing protein. (352 aa)
	PWWP2B	PWWP domain containing 2B. (577 aa)
	PRKAB2	Protein kinase AMP-activated non-catalytic subunit beta 2. (268 aa)
	PHOX2B	Paired like homeobox 2B. (287 aa)
	RB1	Uncharacterized protein. (411 aa)
	GADD45G	Growth arrest and DNA damage inducible gamma. (160 aa)
	PEMT	Phosphatidylethanolamine N-methyltransferase; Catalyzes the three sequential steps of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylethanolamine (PE) to phosphatidylmonomethylethanolamine (PMME), PMME to phosphatidyldimethylethanolamine (PDME), and PDME to phosphatidylcholine (PC); Belongs to the class VI-like SAM-binding methyltransferase superfamily. PEMT/PEM2 methyltransferase family. (226 aa)
	H3A4V3_LATCH	ALMS_motif domain-containing protein. (315 aa)
	ATF4	Activating transcription factor 4. (374 aa)
	ADRB2	Adrenoceptor beta 2. (432 aa)
	H3A2B0_LATCH	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
	HADH	Hydroxyacyl-CoA dehydrogenase. (309 aa)
	ADRB3	Adrenoceptor beta 3a. (407 aa)
	EPAS1	Endothelial PAS domain protein 1. (861 aa)
	LOC102356457	Solute carrier family 25 member 44b; Belongs to the mitochondrial carrier (TC 2.A.29) family. (317 aa)
	CEBPB	CCAAT/enhancer-binding protein. (291 aa)
	OMA1	OMA1 zinc metallopeptidase. (358 aa)
	ZNF516	Zinc finger protein 516. (1157 aa)
	ADIPOQ	Adiponectin, C1Q and collagen domain containing. (259 aa)
	APPL2	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2. (484 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACOT13	HADH	ENSLACP00000009889	ENSLACP00000003504	Acyl-CoA thioesterase 13.	Hydroxyacyl-CoA dehydrogenase.	0.419
ADIPOQ	ADIPOR1	ENSLACP00000000452	ENSLACP00000013484	Adiponectin, C1Q and collagen domain containing.	Adiponectin receptor 1.	0.986
ADIPOQ	ADIPOR2	ENSLACP00000000452	ENSLACP00000020177	Adiponectin, C1Q and collagen domain containing.	Adiponectin receptor 2.	0.981
ADIPOQ	ADRB3	ENSLACP00000000452	ENSLACP00000002909	Adiponectin, C1Q and collagen domain containing.	Adrenoceptor beta 3a.	0.445
ADIPOQ	APPL2	ENSLACP00000000452	ENSLACP00000000307	Adiponectin, C1Q and collagen domain containing.	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2.	0.554
ADIPOQ	CEBPB	ENSLACP00000000452	ENSLACP00000002325	Adiponectin, C1Q and collagen domain containing.	CCAAT/enhancer-binding protein.	0.632
ADIPOQ	GHRL	ENSLACP00000000452	ENSLACP00000015917	Adiponectin, C1Q and collagen domain containing.	Motilin_assoc domain-containing protein.	0.542
ADIPOQ	H3A2B0_LATCH	ENSLACP00000000452	ENSLACP00000003781	Adiponectin, C1Q and collagen domain containing.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.465
ADIPOQ	LEP	ENSLACP00000000452	ENSLACP00000011398	Adiponectin, C1Q and collagen domain containing.	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family.	0.952
ADIPOQ	LEPR	ENSLACP00000000452	ENSLACP00000008593	Adiponectin, C1Q and collagen domain containing.	Leptin receptor.	0.554
ADIPOQ	LOC102350151	ENSLACP00000000452	ENSLACP00000022900	Adiponectin, C1Q and collagen domain containing.	Uncharacterized protein.	0.979
ADIPOQ	PPARGC1A	ENSLACP00000000452	ENSLACP00000015962	Adiponectin, C1Q and collagen domain containing.	PPARG coactivator 1 alpha.	0.604
ADIPOR1	ADIPOQ	ENSLACP00000013484	ENSLACP00000000452	Adiponectin receptor 1.	Adiponectin, C1Q and collagen domain containing.	0.986
ADIPOR1	ADIPOR2	ENSLACP00000013484	ENSLACP00000020177	Adiponectin receptor 1.	Adiponectin receptor 2.	0.926
ADIPOR1	APPL2	ENSLACP00000013484	ENSLACP00000000307	Adiponectin receptor 1.	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2.	0.423
ADIPOR1	LEP	ENSLACP00000013484	ENSLACP00000011398	Adiponectin receptor 1.	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family.	0.517
ADIPOR1	LOC102350151	ENSLACP00000013484	ENSLACP00000022900	Adiponectin receptor 1.	Uncharacterized protein.	0.901
ADIPOR2	ADIPOQ	ENSLACP00000020177	ENSLACP00000000452	Adiponectin receptor 2.	Adiponectin, C1Q and collagen domain containing.	0.981
ADIPOR2	ADIPOR1	ENSLACP00000020177	ENSLACP00000013484	Adiponectin receptor 2.	Adiponectin receptor 1.	0.926
ADIPOR2	APPL2	ENSLACP00000020177	ENSLACP00000000307	Adiponectin receptor 2.	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2.	0.423