(39 nodes) Tight junction assembly network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	H3A9Z9_LATCH	Claudin 23a. (213 aa)
	MICALL2	Uncharacterized protein. (800 aa)
	CLDN34	Uncharacterized protein. (257 aa)
	LOC102362450	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (192 aa)
	CLDN19	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (209 aa)
	CLDN16	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (255 aa)
	CLDN1	Claudin 1. (210 aa)
	LOC102354417	Uncharacterized protein. (723 aa)
	CLDN5	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (213 aa)
	H3B5Z8_LATCH	Uncharacterized protein. (606 aa)
	PARD3	Par-3 family cell polarity regulator. (1214 aa)
	CLDN11	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (209 aa)
	SRF	Serum response factor. (520 aa)
	AFDN	Afadin, adherens junction formation factor. (1854 aa)
	CLDN20	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (221 aa)
	ECT2	Epithelial cell transforming 2. (919 aa)
	LOC102362746	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (210 aa)
	LOC102353037	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (233 aa)
	CLDN14	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (235 aa)
	CDH5	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (772 aa)
	LOC102352776	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (233 aa)
	H3ASJ4_LATCH	Occludin; May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. Belongs to the ELL/occludin family. (532 aa)
	MARVELD2	MARVEL domain containing 2. (563 aa)
	PDCD6IP	Programmed cell death 6 interacting protein. (732 aa)
	TBCD	Tubulin folding cofactor D. (515 aa)
	CLDN7	Claudin 7b. (145 aa)
	H3AI86_LATCH	Uncharacterized protein. (233 aa)
	ESAM	Endothelial cell adhesion molecule. (428 aa)
	H3A984_LATCH	Uncharacterized protein. (365 aa)
	H3A964_LATCH	Si:ch211-191a24.4. (218 aa)
	RAMP2	Uncharacterized protein. (146 aa)
	LOC102365642	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (213 aa)
	CLDN10	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (232 aa)
	LOC106705730	Uncharacterized protein. (200 aa)
	LOC102348536	Uncharacterized protein. (184 aa)
	PAK2	Non-specific serine/threonine protein kinase. (521 aa)
	H3A466_LATCH	ADP-ribosylation factor-like 2; Belongs to the small GTPase superfamily. Arf family. (192 aa)
	LOC102348856	Uncharacterized protein. (190 aa)
	H2ZTR7_LATCH	Uncharacterized protein. (190 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AFDN	CDH5	ENSLACP00000015429	ENSLACP00000012760	Afadin, adherens junction formation factor.	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins.	0.475
AFDN	MARVELD2	ENSLACP00000015429	ENSLACP00000012466	Afadin, adherens junction formation factor.	MARVEL domain containing 2.	0.443
CDH5	AFDN	ENSLACP00000012760	ENSLACP00000015429	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins.	Afadin, adherens junction formation factor.	0.475
CDH5	CLDN5	ENSLACP00000012760	ENSLACP00000017353	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.797
CDH5	ESAM	ENSLACP00000012760	ENSLACP00000008581	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins.	Endothelial cell adhesion molecule.	0.600
CDH5	H3B5Z8_LATCH	ENSLACP00000012760	ENSLACP00000017319	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins.	Uncharacterized protein.	0.691
CDH5	LOC102354417	ENSLACP00000012760	ENSLACP00000017459	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins.	Uncharacterized protein.	0.691
CDH5	PAK2	ENSLACP00000012760	ENSLACP00000004711	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins.	Non-specific serine/threonine protein kinase.	0.635
CDH5	PARD3	ENSLACP00000012760	ENSLACP00000017073	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins.	Par-3 family cell polarity regulator.	0.867
CLDN1	CLDN10	ENSLACP00000017569	ENSLACP00000005269	Claudin 1.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.675
CLDN1	CLDN11	ENSLACP00000017569	ENSLACP00000016560	Claudin 1.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.714
CLDN1	CLDN14	ENSLACP00000017569	ENSLACP00000012827	Claudin 1.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.704
CLDN1	CLDN19	ENSLACP00000017569	ENSLACP00000020552	Claudin 1.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.671
CLDN1	CLDN20	ENSLACP00000017569	ENSLACP00000014449	Claudin 1.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.664
CLDN1	CLDN34	ENSLACP00000017569	ENSLACP00000022250	Claudin 1.	Uncharacterized protein.	0.650
CLDN1	CLDN5	ENSLACP00000017569	ENSLACP00000017353	Claudin 1.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.784
CLDN1	CLDN7	ENSLACP00000017569	ENSLACP00000009714	Claudin 1.	Claudin 7b.	0.663
CLDN1	H3A9Z9_LATCH	ENSLACP00000017569	ENSLACP00000006470	Claudin 1.	Claudin 23a.	0.710
CLDN1	LOC102348536	ENSLACP00000017569	ENSLACP00000004957	Claudin 1.	Uncharacterized protein.	0.774
CLDN1	LOC102348856	ENSLACP00000017569	ENSLACP00000004079	Claudin 1.	Uncharacterized protein.	0.775