(18 nodes) ATP-dependent DNA damage sensor activity network (Latimeria chalumnae)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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Your Input:
	RAD51C	RAD51 paralog C. (368 aa)
	H2ZS42_LATCH	AAA_23 domain-containing protein. (88 aa)
	LOC102360187	MutS homolog 2 (E. coli). (447 aa)
	H2ZX83_LATCH	MutS homolog 2 (E. coli). (360 aa)
	XRCC2	X-ray repair cross complementing 2. (282 aa)
	MSH3	MutS homolog 3; Component of the post-replicative DNA mismatch repair system (MMR). (798 aa)
	H3A560_LATCH	RAD50 homolog, double strand break repair protein. (1193 aa)
	MLH1	MutL homolog 1. (821 aa)
	XRCC3	DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (358 aa)
	PMS1	PMS1 homolog 1, mismatch repair system component. (1040 aa)
	MSH6	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1361 aa)
	H3BAV2_LATCH	Uncharacterized protein. (105 aa)
	RAD51	DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (341 aa)
	RAD51B	RAD51 paralog B. (250 aa)
	MLH3	MutL homolog 3. (1437 aa)
	PMS2	PMS1 homolog 2, mismatch repair system component. (872 aa)
	DMC1	Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily. (317 aa)
	MSH4	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (955 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DMC1	H2ZS42_LATCH	ENSLACP00000022936	ENSLACP00000000213	Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily.	AAA_23 domain-containing protein.	0.705
DMC1	H2ZX83_LATCH	ENSLACP00000022936	ENSLACP00000002004	Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily.	MutS homolog 2 (E. coli).	0.534
DMC1	H3A560_LATCH	ENSLACP00000022936	ENSLACP00000004781	Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily.	RAD50 homolog, double strand break repair protein.	0.705
DMC1	H3BAV2_LATCH	ENSLACP00000022936	ENSLACP00000019023	Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily.	Uncharacterized protein.	0.882
DMC1	LOC102360187	ENSLACP00000022936	ENSLACP00000000628	Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily.	MutS homolog 2 (E. coli).	0.534
DMC1	MLH1	ENSLACP00000022936	ENSLACP00000008921	Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily.	MutL homolog 1.	0.682
DMC1	MLH3	ENSLACP00000022936	ENSLACP00000020860	Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily.	MutL homolog 3.	0.595
DMC1	MSH4	ENSLACP00000022936	ENSLACP00000023534	Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily.	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.729
DMC1	MSH6	ENSLACP00000022936	ENSLACP00000017187	Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily.	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.519
DMC1	PMS1	ENSLACP00000022936	ENSLACP00000016464	Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily.	PMS1 homolog 1, mismatch repair system component.	0.443
DMC1	PMS2	ENSLACP00000022936	ENSLACP00000022793	Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily.	PMS1 homolog 2, mismatch repair system component.	0.443
DMC1	RAD51	ENSLACP00000022936	ENSLACP00000019416	Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily.	DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...]	0.973
DMC1	RAD51B	ENSLACP00000022936	ENSLACP00000019703	Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily.	RAD51 paralog B.	0.882
DMC1	RAD51C	ENSLACP00000022936	ENSLACP00000000198	Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily.	RAD51 paralog C.	0.592
DMC1	XRCC2	ENSLACP00000022936	ENSLACP00000003696	Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily.	X-ray repair cross complementing 2.	0.918
DMC1	XRCC3	ENSLACP00000022936	ENSLACP00000009862	Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily.	DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily.	0.977
H2ZS42_LATCH	DMC1	ENSLACP00000000213	ENSLACP00000022936	AAA_23 domain-containing protein.	Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily.	0.705
H2ZS42_LATCH	H3BAV2_LATCH	ENSLACP00000000213	ENSLACP00000019023	AAA_23 domain-containing protein.	Uncharacterized protein.	0.752
H2ZS42_LATCH	RAD51	ENSLACP00000000213	ENSLACP00000019416	AAA_23 domain-containing protein.	DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...]	0.857
H2ZS42_LATCH	RAD51B	ENSLACP00000000213	ENSLACP00000019703	AAA_23 domain-containing protein.	RAD51 paralog B.	0.765