(30 nodes) Regulation of cytokine production involved in inflammatory response network (Latimeria chalumnae)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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protein homology

Your Input:
	MYD88	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (286 aa)
	CUEDC2	CUE domain containing 2. (154 aa)
	ZC3H12A	Zinc finger CCCH-type containing 12A. (600 aa)
	CARD9	Caspase recruitment domain family member 9. (567 aa)
	PLD3	Phospholipase D family member 3. (496 aa)
	F2	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. (618 aa)
	APOD	Apolipoprotein D; Belongs to the calycin superfamily. Lipocalin family. (189 aa)
	IL17B	Interleukin 17B. (197 aa)
	LEP	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family. (169 aa)
	NLRC3	NLR family CARD domain containing 3. (1005 aa)
	PPARA	Peroxisome proliferator activated receptor alpha. (468 aa)
	LOC102362454	Uncharacterized protein. (158 aa)
	LOC102349920	Uncharacterized protein. (199 aa)
	PLD4	Phospholipase D family member 4. (440 aa)
	IL6	Uncharacterized protein. (149 aa)
	H3AEV1_LATCH	TNF_2 domain-containing protein. (230 aa)
	ANKRD42	Ankyrin repeat domain 42. (509 aa)
	LOC102361756	Phospholipase D family, member 7. (413 aa)
	H3A8Y5_LATCH	Uncharacterized protein. (477 aa)
	IL1R2	Interleukin 1 receptor type 2. (378 aa)
	ABCD2	ATP binding cassette subfamily D member 2. (743 aa)
	ABCD1	ATP binding cassette subfamily D member 1. (749 aa)
	H2ZU28_LATCH	SEFIR domain-containing protein. (634 aa)
	APPL2	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2. (484 aa)
	H2ZS97_LATCH	TNF_2 domain-containing protein. (143 aa)
	APPL1	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1. (709 aa)
	STAT3	Signal transducer and activator of transcription. (763 aa)
	PDCD4	Programmed cell death 4. (466 aa)
	H3B4J4_LATCH	Uncharacterized protein. (982 aa)
	H3B9K7_LATCH	SEFIR domain-containing protein. (774 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABCD1	ABCD2	ENSLACP00000001162	ENSLACP00000005686	ATP binding cassette subfamily D member 1.	ATP binding cassette subfamily D member 2.	0.901
ABCD2	ABCD1	ENSLACP00000005686	ENSLACP00000001162	ATP binding cassette subfamily D member 2.	ATP binding cassette subfamily D member 1.	0.901
APPL1	APPL2	ENSLACP00000012610	ENSLACP00000000307	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1.	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2.	0.997
APPL2	APPL1	ENSLACP00000000307	ENSLACP00000012610	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2.	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1.	0.997
CARD9	MYD88	ENSLACP00000020146	ENSLACP00000019094	Caspase recruitment domain family member 9.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.547
F2	IL6	ENSLACP00000021404	ENSLACP00000009318	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	Uncharacterized protein.	0.422
H2ZS97_LATCH	IL6	ENSLACP00000000268	ENSLACP00000009318	TNF_2 domain-containing protein.	Uncharacterized protein.	0.470
H2ZU28_LATCH	H3B9K7_LATCH	ENSLACP00000000899	ENSLACP00000018578	SEFIR domain-containing protein.	SEFIR domain-containing protein.	0.884
H2ZU28_LATCH	IL17B	ENSLACP00000000899	ENSLACP00000022780	SEFIR domain-containing protein.	Interleukin 17B.	0.505
H2ZU28_LATCH	LOC102362454	ENSLACP00000000899	ENSLACP00000010226	SEFIR domain-containing protein.	Uncharacterized protein.	0.538
H3AEV1_LATCH	IL6	ENSLACP00000008172	ENSLACP00000009318	TNF_2 domain-containing protein.	Uncharacterized protein.	0.470
H3B9K7_LATCH	H2ZU28_LATCH	ENSLACP00000018578	ENSLACP00000000899	SEFIR domain-containing protein.	SEFIR domain-containing protein.	0.884
H3B9K7_LATCH	IL17B	ENSLACP00000018578	ENSLACP00000022780	SEFIR domain-containing protein.	Interleukin 17B.	0.422
H3B9K7_LATCH	LOC102362454	ENSLACP00000018578	ENSLACP00000010226	SEFIR domain-containing protein.	Uncharacterized protein.	0.604
IL17B	H2ZU28_LATCH	ENSLACP00000022780	ENSLACP00000000899	Interleukin 17B.	SEFIR domain-containing protein.	0.505
IL17B	H3B9K7_LATCH	ENSLACP00000022780	ENSLACP00000018578	Interleukin 17B.	SEFIR domain-containing protein.	0.422
IL1R2	IL6	ENSLACP00000005998	ENSLACP00000009318	Interleukin 1 receptor type 2.	Uncharacterized protein.	0.437
IL6	F2	ENSLACP00000009318	ENSLACP00000021404	Uncharacterized protein.	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	0.422
IL6	H2ZS97_LATCH	ENSLACP00000009318	ENSLACP00000000268	Uncharacterized protein.	TNF_2 domain-containing protein.	0.470
IL6	H3AEV1_LATCH	ENSLACP00000009318	ENSLACP00000008172	Uncharacterized protein.	TNF_2 domain-containing protein.	0.470