(13 nodes) Positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	JUN	Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (311 aa)
	CARF	Calcium responsive transcription factor. (734 aa)
	H3B2C8_LATCH	Uncharacterized protein. (389 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (401 aa)
	SMAD1	Mothers against decapentaplegic homolog. (465 aa)
	NFE2L2	Nuclear factor, erythroid 2 like 2. (590 aa)
	LOC102352539	Uncharacterized protein. (949 aa)
	CREB3	cAMP responsive element binding protein 3. (452 aa)
	SMAD5	Mothers against decapentaplegic homolog. (467 aa)
	RBPJ	Recombination signal binding protein for immunoglobulin kappa J region. (487 aa)
	H3AD77_LATCH	JunE proto-oncogene, AP-1 transcription factor subunit. (316 aa)
	ATF4	Activating transcription factor 4. (374 aa)
	DLX5	Distal-less homeobox 5. (290 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATF4	CREB3	ENSLACP00000004433	ENSLACP00000008681	Activating transcription factor 4.	cAMP responsive element binding protein 3.	0.908
ATF4	H3AD77_LATCH	ENSLACP00000004433	ENSLACP00000007598	Activating transcription factor 4.	JunE proto-oncogene, AP-1 transcription factor subunit.	0.633
ATF4	H3B2C8_LATCH	ENSLACP00000004433	ENSLACP00000016049	Activating transcription factor 4.	Uncharacterized protein.	0.770
ATF4	JUN	ENSLACP00000004433	ENSLACP00000005596	Activating transcription factor 4.	Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family.	0.646
ATF4	LOC102352539	ENSLACP00000004433	ENSLACP00000009233	Activating transcription factor 4.	Uncharacterized protein.	0.642
ATF4	NFE2L2	ENSLACP00000004433	ENSLACP00000009979	Activating transcription factor 4.	Nuclear factor, erythroid 2 like 2.	0.602
CREB3	ATF4	ENSLACP00000008681	ENSLACP00000004433	cAMP responsive element binding protein 3.	Activating transcription factor 4.	0.908
H3AD77_LATCH	ATF4	ENSLACP00000007598	ENSLACP00000004433	JunE proto-oncogene, AP-1 transcription factor subunit.	Activating transcription factor 4.	0.633
H3AD77_LATCH	JUN	ENSLACP00000007598	ENSLACP00000005596	JunE proto-oncogene, AP-1 transcription factor subunit.	Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family.	0.901
H3AD77_LATCH	LOC102352539	ENSLACP00000007598	ENSLACP00000009233	JunE proto-oncogene, AP-1 transcription factor subunit.	Uncharacterized protein.	0.859
H3AD77_LATCH	NFE2L2	ENSLACP00000007598	ENSLACP00000009979	JunE proto-oncogene, AP-1 transcription factor subunit.	Nuclear factor, erythroid 2 like 2.	0.493
H3AD77_LATCH	TP53	ENSLACP00000007598	ENSLACP00000015915	JunE proto-oncogene, AP-1 transcription factor subunit.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.603
H3B2C8_LATCH	ATF4	ENSLACP00000016049	ENSLACP00000004433	Uncharacterized protein.	Activating transcription factor 4.	0.770
JUN	ATF4	ENSLACP00000005596	ENSLACP00000004433	Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family.	Activating transcription factor 4.	0.646
JUN	H3AD77_LATCH	ENSLACP00000005596	ENSLACP00000007598	Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family.	JunE proto-oncogene, AP-1 transcription factor subunit.	0.901
JUN	LOC102352539	ENSLACP00000005596	ENSLACP00000009233	Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family.	Uncharacterized protein.	0.859
JUN	NFE2L2	ENSLACP00000005596	ENSLACP00000009979	Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family.	Nuclear factor, erythroid 2 like 2.	0.493
JUN	TP53	ENSLACP00000005596	ENSLACP00000015915	Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.603
LOC102352539	ATF4	ENSLACP00000009233	ENSLACP00000004433	Uncharacterized protein.	Activating transcription factor 4.	0.642
LOC102352539	H3AD77_LATCH	ENSLACP00000009233	ENSLACP00000007598	Uncharacterized protein.	JunE proto-oncogene, AP-1 transcription factor subunit.	0.859