(85 nodes) Positive regulation of leukocyte differentiation network (Latimeria chalumnae)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PTPRC	Protein tyrosine phosphatase receptor type C. (830 aa)
	TGFBR2	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (585 aa)
	RIPK2	Receptor interacting serine/threonine kinase 2. (567 aa)
	H3A526_LATCH	Uncharacterized protein; Belongs to the peptidase C14A family. (486 aa)
	RB1	Uncharacterized protein. (411 aa)
	IL10	Interleukin 10. (185 aa)
	LEF1	Lymphoid enhancer binding factor 1. (397 aa)
	H3A7T5_LATCH	Uncharacterized protein. (999 aa)
	LOC102362196	Ig-like domain-containing protein. (206 aa)
	H3ABW1_LATCH	ANK_REP_REGION domain-containing protein. (323 aa)
	CTNNBIP1	Catenin beta interacting protein 1. (81 aa)
	TMEM64	Transmembrane protein 64. (350 aa)
	NFKBIZ	NFKB inhibitor zeta. (622 aa)
	H3AEV1_LATCH	TNF_2 domain-containing protein. (230 aa)
	CBFB	Core-binding factor subunit beta. (189 aa)
	ZAP70	Tyrosine-protein kinase. (609 aa)
	H3AGM7_LATCH	Fibronectin type-III domain-containing protein. (234 aa)
	TNFSF11	TNF superfamily member 11; Belongs to the tumor necrosis factor family. (169 aa)
	SOCS1	Suppressor of cytokine signaling 1a. (190 aa)
	H3AJR0_LATCH	SRY-box transcription factor 13. (427 aa)
	FADD	Fas associated via death domain. (193 aa)
	HLX	H2.0 like homeobox. (384 aa)
	LOC102346566	Annexin. (343 aa)
	TOX	Thymocyte selection associated high mobility group box. (392 aa)
	TESC	Tescalcin. (218 aa)
	H3ALU7_LATCH	NACHT domain-containing protein. (877 aa)
	SOX13	Uncharacterized protein. (195 aa)
	RIPK1	Receptor interacting serine/threonine kinase 1. (667 aa)
	BAD	Uncharacterized protein. (175 aa)
	H3APC7_LATCH	NACHT domain-containing protein. (686 aa)
	RASGRP1	RAS guanyl releasing protein 1. (719 aa)
	H3AQ35_LATCH	NACHT domain-containing protein. (880 aa)
	LOC102367007	Uncharacterized protein. (335 aa)
	H3ASA2_LATCH	Ig-like domain-containing protein. (290 aa)
	H3ASJ2_LATCH	ANK_REP_REGION domain-containing protein. (303 aa)
	SART1	Spliceosome associated factor 1, recruiter of U4/U6.U5 tri-snRNP. (649 aa)
	RHOH	Ras homolog family member H. (189 aa)
	PPARGC1B	PPARG coactivator 1 beta. (986 aa)
	SYK	Tyrosine-protein kinase. (616 aa)
	HAX1	HCLS1 associated protein X-1. (249 aa)
	INPP5D	Inositol polyphosphate-5-phosphatase D. (1144 aa)
	KLF10	Kruppel like factor 10. (476 aa)
	H3B0U4_LATCH	MALT paracaspase 2. (695 aa)
	SASH3	SAM and SH3 domain containing 3. (433 aa)
	H3B2C8_LATCH	Uncharacterized protein. (389 aa)
	GAS6	Uncharacterized protein. (681 aa)
	TESPA1	KRAP_IP3R_bind domain-containing protein. (96 aa)
	H3B5B6_LATCH	NACHT domain-containing protein. (692 aa)
	ACIN1	SAP domain-containing protein. (1277 aa)
	LOC102353021	Uncharacterized protein. (644 aa)
	CREB1	cAMP responsive element binding protein 1. (347 aa)
	DUSP10	Dual specificity phosphatase 10. (481 aa)
	CD74	CD74 molecule. (279 aa)
	ZBTB1	Zinc finger and BTB domain containing 1. (706 aa)
	H3BAX4_LATCH	DC_STAMP domain-containing protein. (450 aa)
	PPP2R3C	Protein phosphatase 2 regulatory subunit B''gamma. (451 aa)
	AXL	AXL receptor tyrosine kinase. (872 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (401 aa)
	FOS	Fos proto-oncogene, AP-1 transcription factor subunit. (391 aa)
	RASGRP4	RAS guanyl releasing protein 4. (692 aa)
	ZBTB16	Zinc finger and BTB domain containing 16. (420 aa)
	H3BH49_LATCH	Ig-like domain-containing protein. (195 aa)
	MDK	Midkine. (141 aa)
	AMBRA1	Autophagy and beclin 1 regulator 1. (1195 aa)
	IL18	Uncharacterized protein. (200 aa)
	LOC102356247	Uncharacterized protein. (636 aa)
	MMP14	Matrix metallopeptidase 14. (597 aa)
	LOC102348796	Uncharacterized protein. (497 aa)
	GLI3	GLI family zinc finger 3. (1456 aa)
	MALT1	MALT1 paracaspase. (825 aa)
	PCID2	PCI domain containing 2. (452 aa)
	H3A2R2_LATCH	Uncharacterized protein; Belongs to the peptidase C14A family. (480 aa)
	TRAF6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (559 aa)
	GATA3	GATA binding protein 3. (447 aa)
	LOC102348725	Uncharacterized protein. (641 aa)
	MYB	MYB proto-oncogene, transcription factor. (761 aa)
	SOCS5	Suppressor of cytokine signaling 5. (538 aa)
	NEDD9	Neural precursor cell expressed, developmentally down-regulated 9. (901 aa)
	CASP10	Caspase 10; Belongs to the peptidase C14A family. (539 aa)
	H2ZX66_LATCH	Uncharacterized protein. (641 aa)
	H2ZX20_LATCH	Uncharacterized protein. (1016 aa)
	ROR2	Receptor tyrosine kinase like orphan receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (882 aa)
	H2ZSX8_LATCH	Fibronectin type-III domain-containing protein. (243 aa)
	H2ZSP9_LATCH	Uncharacterized protein. (997 aa)
	H2ZS97_LATCH	TNF_2 domain-containing protein. (143 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AMBRA1	TRAF6	ENSLACP00000021333	ENSLACP00000003556	Autophagy and beclin 1 regulator 1.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.747
AXL	GAS6	ENSLACP00000020423	ENSLACP00000016134	AXL receptor tyrosine kinase.	Uncharacterized protein.	0.704
AXL	SOCS1	ENSLACP00000020423	ENSLACP00000009341	AXL receptor tyrosine kinase.	Suppressor of cytokine signaling 1a.	0.499
CASP10	FADD	ENSLACP00000002069	ENSLACP00000009943	Caspase 10; Belongs to the peptidase C14A family.	Fas associated via death domain.	0.996
CASP10	H3B0U4_LATCH	ENSLACP00000002069	ENSLACP00000015515	Caspase 10; Belongs to the peptidase C14A family.	MALT paracaspase 2.	0.959
CASP10	LOC102348796	ENSLACP00000002069	ENSLACP00000023619	Caspase 10; Belongs to the peptidase C14A family.	Uncharacterized protein.	0.467
CASP10	LOC102353021	ENSLACP00000002069	ENSLACP00000018014	Caspase 10; Belongs to the peptidase C14A family.	Uncharacterized protein.	0.955
CASP10	MALT1	ENSLACP00000002069	ENSLACP00000004155	Caspase 10; Belongs to the peptidase C14A family.	MALT1 paracaspase.	0.959
CASP10	RIPK1	ENSLACP00000002069	ENSLACP00000011259	Caspase 10; Belongs to the peptidase C14A family.	Receptor interacting serine/threonine kinase 1.	0.921
CASP10	RIPK2	ENSLACP00000002069	ENSLACP00000004499	Caspase 10; Belongs to the peptidase C14A family.	Receptor interacting serine/threonine kinase 2.	0.467
CASP10	SYK	ENSLACP00000002069	ENSLACP00000012982	Caspase 10; Belongs to the peptidase C14A family.	Tyrosine-protein kinase.	0.427
CASP10	TRAF6	ENSLACP00000002069	ENSLACP00000003556	Caspase 10; Belongs to the peptidase C14A family.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.577
CASP10	ZAP70	ENSLACP00000002069	ENSLACP00000008633	Caspase 10; Belongs to the peptidase C14A family.	Tyrosine-protein kinase.	0.417
CBFB	GATA3	ENSLACP00000008364	ENSLACP00000003446	Core-binding factor subunit beta.	GATA binding protein 3.	0.711
CBFB	TGFB1	ENSLACP00000008364	ENSLACP00000020652	Core-binding factor subunit beta.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.465
CD74	H3B2C8_LATCH	ENSLACP00000018188	ENSLACP00000016049	CD74 molecule.	Uncharacterized protein.	0.465
CD74	PTPRC	ENSLACP00000018188	ENSLACP00000003518	CD74 molecule.	Protein tyrosine phosphatase receptor type C.	0.522
CREB1	FOS	ENSLACP00000018100	ENSLACP00000020665	cAMP responsive element binding protein 1.	Fos proto-oncogene, AP-1 transcription factor subunit.	0.805
CREB1	GATA3	ENSLACP00000018100	ENSLACP00000003446	cAMP responsive element binding protein 1.	GATA binding protein 3.	0.442
CREB1	IL10	ENSLACP00000018100	ENSLACP00000005382	cAMP responsive element binding protein 1.	Interleukin 10.	0.540