(34 nodes) Regulation of endothelial cell apoptotic process network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	TEK	TEK receptor tyrosine kinase. (914 aa)
	KDR	Kinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1339 aa)
	CDH5	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (772 aa)
	BRAF	B-Raf proto-oncogene, serine/threonine kinase. (768 aa)
	RGCC	Regulator of cell cycle. (127 aa)
	NDNF	Neuron derived neurotrophic factor. (571 aa)
	PDCD4	Programmed cell death 4. (466 aa)
	GAS6	Uncharacterized protein. (681 aa)
	ITGA4	Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (1037 aa)
	TNFAIP3	TNF alpha induced protein 3. (785 aa)
	FASLG	Fas ligand. (261 aa)
	ABL1	Tyrosine-protein kinase. (1156 aa)
	CD40LG	CD40 ligand; Belongs to the tumor necrosis factor family. (284 aa)
	LOC102366055	Uncharacterized protein. (579 aa)
	H2ZS97_LATCH	TNF_2 domain-containing protein. (143 aa)
	H3B4J4_LATCH	Uncharacterized protein. (982 aa)
	ANGPTL4	Angiopoietin like 4. (459 aa)
	THBS1	Thrombospondin 1. (1170 aa)
	KRIT1	KRIT1 ankyrin repeat containing. (733 aa)
	SCG2	Secretogranin II. (621 aa)
	GATA3	GATA binding protein 3. (447 aa)
	H3A2B0_LATCH	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
	CD40	TNFR-Cys domain-containing protein. (167 aa)
	IL10	Interleukin 10. (185 aa)
	ANO6	Anoctamin. (766 aa)
	RAMP2	Uncharacterized protein. (146 aa)
	SERPINE1	Serpin family E member 1; Belongs to the serpin family. (403 aa)
	ABL2	Tyrosine-protein kinase. (1175 aa)
	FGG	Fibrinogen gamma chain. (376 aa)
	CD248	CD248 molecule, endosialin a. (550 aa)
	GPER1	G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (366 aa)
	H3AEV1_LATCH	TNF_2 domain-containing protein. (230 aa)
	FGB	Fibrinogen beta chain. (454 aa)
	NFE2L2	Nuclear factor, erythroid 2 like 2. (590 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABL1	ABL2	ENSLACP00000017765	ENSLACP00000006377	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.902
ABL2	ABL1	ENSLACP00000006377	ENSLACP00000017765	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.902
ANGPTL4	CDH5	ENSLACP00000019347	ENSLACP00000012760	Angiopoietin like 4.	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins.	0.592
BRAF	FGB	ENSLACP00000012774	ENSLACP00000008521	B-Raf proto-oncogene, serine/threonine kinase.	Fibrinogen beta chain.	0.502
CD40	CD40LG	ENSLACP00000004148	ENSLACP00000017831	TNFR-Cys domain-containing protein.	CD40 ligand; Belongs to the tumor necrosis factor family.	0.992
CD40	FASLG	ENSLACP00000004148	ENSLACP00000017423	TNFR-Cys domain-containing protein.	Fas ligand.	0.644
CD40	H2ZS97_LATCH	ENSLACP00000004148	ENSLACP00000000268	TNFR-Cys domain-containing protein.	TNF_2 domain-containing protein.	0.481
CD40	H3AEV1_LATCH	ENSLACP00000004148	ENSLACP00000008172	TNFR-Cys domain-containing protein.	TNF_2 domain-containing protein.	0.481
CD40	IL10	ENSLACP00000004148	ENSLACP00000005382	TNFR-Cys domain-containing protein.	Interleukin 10.	0.712
CD40LG	CD40	ENSLACP00000017831	ENSLACP00000004148	CD40 ligand; Belongs to the tumor necrosis factor family.	TNFR-Cys domain-containing protein.	0.992
CD40LG	FASLG	ENSLACP00000017831	ENSLACP00000017423	CD40 ligand; Belongs to the tumor necrosis factor family.	Fas ligand.	0.504
CD40LG	IL10	ENSLACP00000017831	ENSLACP00000005382	CD40 ligand; Belongs to the tumor necrosis factor family.	Interleukin 10.	0.557
CDH5	ANGPTL4	ENSLACP00000012760	ENSLACP00000019347	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins.	Angiopoietin like 4.	0.592
CDH5	KDR	ENSLACP00000012760	ENSLACP00000011126	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins.	Kinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.824
CDH5	KRIT1	ENSLACP00000012760	ENSLACP00000000694	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins.	KRIT1 ankyrin repeat containing.	0.451
CDH5	TEK	ENSLACP00000012760	ENSLACP00000011084	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins.	TEK receptor tyrosine kinase.	0.613
FASLG	CD40	ENSLACP00000017423	ENSLACP00000004148	Fas ligand.	TNFR-Cys domain-containing protein.	0.644
FASLG	CD40LG	ENSLACP00000017423	ENSLACP00000017831	Fas ligand.	CD40 ligand; Belongs to the tumor necrosis factor family.	0.504
FASLG	IL10	ENSLACP00000017423	ENSLACP00000005382	Fas ligand.	Interleukin 10.	0.566
FGB	BRAF	ENSLACP00000008521	ENSLACP00000012774	Fibrinogen beta chain.	B-Raf proto-oncogene, serine/threonine kinase.	0.502