STRINGSTRING
RBCK1 RBCK1 SHARPIN SHARPIN PIAS4 PIAS4 LOC102360171 LOC102360171 HTRA2 HTRA2 FBXW9 FBXW9 PPP2R1A PPP2R1A APAF1 APAF1 PDIA3 PDIA3 EEF1E1 EEF1E1 FBH1 FBH1 H3B0U5_LATCH H3B0U5_LATCH TP53 TP53 TIMP3 TIMP3 SKIL SKIL WWOX WWOX RACK1 RACK1 INHBB INHBB SRPX SRPX RNF183 RNF183 NF1 NF1 MYC MYC THBS1 THBS1 CAV3 CAV3 STYXL1 STYXL1 G0S2 G0S2 PPP2R1B PPP2R1B DDIT3 DDIT3 BCLAF1 BCLAF1 FBXW7 FBXW7 TPD52L1 TPD52L1 TP63 TP63 AGT AGT DEDD2 DEDD2 CRADD CRADD ZSWIM2 ZSWIM2 FAF1 FAF1 H2ZV40_LATCH H2ZV40_LATCH ATF3 ATF3 CTSC CTSC LOC102346204 LOC102346204 MAPK9 MAPK9 STK4 STK4 H2ZZY5_LATCH H2ZZY5_LATCH CASP2 CASP2 PTPRC PTPRC NCK1 NCK1 MSX1 MSX1 PAK2 PAK2 PEA15 PEA15 BAD BAD INHBA INHBA PTPN2 PTPN2 LOC102365523 LOC102365523 CTSH CTSH FAS FAS RPS3 RPS3 BAX BAX PLAGL2 PLAGL2 GPER1 GPER1 TGFBR1 TGFBR1 GSDME GSDME LTBR LTBR SIRT1 SIRT1 H3AHH6_LATCH H3AHH6_LATCH TRAF7 TRAF7 BOK BOK FADD FADD LOC102349920 LOC102349920 NCK2 NCK2 PLEKHF1 PLEKHF1 AGTR2 AGTR2 FLCN FLCN CYLD CYLD DNM1L DNM1L RIPK1 RIPK1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RBCK1IBR domain-containing protein. (175 aa)
SHARPINUncharacterized protein. (681 aa)
PIAS4Protein inhibitor of activated STAT 4. (370 aa)
LOC102360171Si:dkey-32e23.4; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (426 aa)
HTRA2HtrA serine peptidase 2. (525 aa)
FBXW9F-box and WD repeat domain containing 9. (465 aa)
PPP2R1AProtein phosphatase 2 scaffold subunit Aalpha. (591 aa)
APAF1Apoptotic peptidase activating factor 1. (1202 aa)
PDIA3Protein disulfide-isomerase. (497 aa)
EEF1E1Eukaryotic translation elongation factor 1 epsilon 1. (107 aa)
FBH1F-box DNA helicase 1. (795 aa)
H3B0U5_LATCHPept_C1 domain-containing protein; Belongs to the peptidase C1 family. (436 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (401 aa)
TIMP3TIMP metallopeptidase inhibitor 3. (216 aa)
SKILSKI like proto-oncogene. (691 aa)
WWOXWW domain containing oxidoreductase. (353 aa)
RACK1Receptor for activated C kinase 1. (317 aa)
INHBBInhibin subunit beta B. (393 aa)
SRPXSushi repeat containing protein X-linked. (410 aa)
RNF183Ring finger protein 183. (191 aa)
NF1Neurofibromin 1. (2814 aa)
MYCTranscriptional regulator; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (412 aa)
THBS1Thrombospondin 1. (1170 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (153 aa)
STYXL1Serine/threonine/tyrosine interacting-like 1. (324 aa)
G0S2G0/G1 switch 2. (100 aa)
PPP2R1BProtein phosphatase 2 scaffold subunit Abeta. (589 aa)
DDIT3DNA damage inducible transcript 3. (256 aa)
BCLAF1BCL2 associated transcription factor 1. (946 aa)
FBXW7F-box and WD repeat domain containing 7. (713 aa)
TPD52L1TPD52 like 1. (190 aa)
TP63Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (637 aa)
AGTSERPIN domain-containing protein; Belongs to the serpin family. (470 aa)
DEDD2Death effector domain containing 2. (372 aa)
CRADDCASP2 and RIPK1 domain containing adaptor with death domain. (143 aa)
ZSWIM2Zinc finger SWIM-type containing 2. (636 aa)
FAF1Fas associated factor 1. (428 aa)
H2ZV40_LATCHProtein kinase domain-containing protein. (266 aa)
ATF3Activating transcription factor 3. (179 aa)
CTSCCathepsin C; Belongs to the peptidase C1 family. (461 aa)
LOC102346204Protein kinase domain-containing protein. (227 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
STK4Serine/threonine kinase 4. (488 aa)
H2ZZY5_LATCHUncharacterized protein. (548 aa)
CASP2Caspase 2; Belongs to the peptidase C14A family. (433 aa)
PTPRCProtein tyrosine phosphatase receptor type C. (830 aa)
NCK1Cytoplasmic protein. (377 aa)
MSX1Msh homeobox 1. (256 aa)
PAK2Non-specific serine/threonine protein kinase. (521 aa)
PEA15Proliferation and apoptosis adaptor protein 15. (133 aa)
BADUncharacterized protein. (175 aa)
INHBAInhibin subunit beta A. (390 aa)
PTPN2Tyrosine-protein phosphatase non-receptor type. (397 aa)
LOC102365523Uncharacterized protein; Belongs to the peptidase C19 family. (930 aa)
CTSHCathepsin H; Belongs to the peptidase C1 family. (329 aa)
FASUncharacterized protein. (330 aa)
RPS3KH type-2 domain-containing protein; Belongs to the universal ribosomal protein uS3 family. (254 aa)
BAXUncharacterized protein. (223 aa)
PLAGL2PLAG1 like zinc finger 2. (507 aa)
GPER1G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (366 aa)
TGFBR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (507 aa)
GSDMEUncharacterized protein. (491 aa)
LTBRLymphotoxin beta receptor. (377 aa)
SIRT1Sirtuin 1. (729 aa)
H3AHH6_LATCHRHD domain-containing protein. (288 aa)
TRAF7TNF receptor associated factor 7. (671 aa)
BOKBCL2 family apoptosis regulator BOK. (111 aa)
FADDFas associated via death domain. (193 aa)
LOC102349920Uncharacterized protein. (199 aa)
NCK2Cytoplasmic protein. (380 aa)
PLEKHF1Pleckstrin homology and FYVE domain containing 1. (274 aa)
AGTR2Angiotensin II receptor type 2; Belongs to the G-protein coupled receptor 1 family. (377 aa)
FLCNFolliculin. (576 aa)
CYLDCYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family. (959 aa)
DNM1LDynamin 1 like; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (778 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (667 aa)
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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