(29 nodes) Photoreceptor outer segment network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	DHRS3	Dehydrogenase/reductase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (303 aa)
	GUCY2D	Guanylate cyclase. (1026 aa)
	PPEF1	Serine/threonine-protein phosphatase with EF-hands. (732 aa)
	PDE6A	Phosphodiesterase. (862 aa)
	RD3	Retinal degeneration 3, GUCY2D regulator. (197 aa)
	H3B0H2_LATCH	Uncharacterized protein. (441 aa)
	OPN5	Opsin 5; Belongs to the G-protein coupled receptor 1 family. (290 aa)
	CDHR1	Cadherin related family member 1. (688 aa)
	CFAP410	Cilia and flagella associated protein 410. (253 aa)
	LOC102362011	Uncharacterized protein. (111 aa)
	H2ZS04_LATCH	Guanylate cyclase. (828 aa)
	GUCA1B	Uncharacterized protein. (197 aa)
	LYAR	Ly1 antibody reactive. (403 aa)
	ROM1	Retinal outer segment membrane protein 1. (357 aa)
	LOC102359416	Uncharacterized protein. (359 aa)
	GUCA1A	Guanylate cyclase activator 1A. (202 aa)
	RP1L1	Uncharacterized protein. (1547 aa)
	H3A7M4_LATCH	Phosphodiesterase. (663 aa)
	GUCY2F	Guanylate cyclase. (1115 aa)
	GRK7	G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (536 aa)
	GNA11	G protein subunit alpha 11. (433 aa)
	RP1	RP1 axonemal microtubule associated. (1901 aa)
	RPGR	Retinitis pigmentosa GTPase regulator. (1152 aa)
	GUCA1C	Guanylate cyclase activator 1C. (191 aa)
	PDE6G	Phosphodiesterase 6G. (101 aa)
	SAG	S-antigen visual arrestin. (317 aa)
	PPEF2	Serine/threonine-protein phosphatase with EF-hands. (700 aa)
	H3ALJ8_LATCH	PDEase domain-containing protein. (155 aa)
	MERTK	MER proto-oncogene, tyrosine kinase. (897 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
GNA11	GRK7	ENSLACP00000016492	ENSLACP00000005098	G protein subunit alpha 11.	G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.	0.566
GNA11	OPN5	ENSLACP00000016492	ENSLACP00000015674	G protein subunit alpha 11.	Opsin 5; Belongs to the G-protein coupled receptor 1 family.	0.404
GRK7	GNA11	ENSLACP00000005098	ENSLACP00000016492	G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.	G protein subunit alpha 11.	0.566
GRK7	GUCA1A	ENSLACP00000005098	ENSLACP00000007638	G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.	Guanylate cyclase activator 1A.	0.567
GRK7	GUCA1B	ENSLACP00000005098	ENSLACP00000021167	G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.	Uncharacterized protein.	0.584
GRK7	LOC102359416	ENSLACP00000005098	ENSLACP00000007711	G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.	Uncharacterized protein.	0.566
GRK7	PDE6A	ENSLACP00000005098	ENSLACP00000013636	G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.	Phosphodiesterase.	0.630
GRK7	PDE6G	ENSLACP00000005098	ENSLACP00000019565	G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.	Phosphodiesterase 6G.	0.403
GRK7	SAG	ENSLACP00000005098	ENSLACP00000003617	G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.	S-antigen visual arrestin.	0.704
GUCA1A	GRK7	ENSLACP00000007638	ENSLACP00000005098	Guanylate cyclase activator 1A.	G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.	0.567
GUCA1A	GUCA1B	ENSLACP00000007638	ENSLACP00000021167	Guanylate cyclase activator 1A.	Uncharacterized protein.	0.769
GUCA1A	GUCA1C	ENSLACP00000007638	ENSLACP00000019179	Guanylate cyclase activator 1A.	Guanylate cyclase activator 1C.	0.608
GUCA1A	GUCY2D	ENSLACP00000007638	ENSLACP00000011923	Guanylate cyclase activator 1A.	Guanylate cyclase.	0.573
GUCA1A	GUCY2F	ENSLACP00000007638	ENSLACP00000005372	Guanylate cyclase activator 1A.	Guanylate cyclase.	0.577
GUCA1A	H2ZS04_LATCH	ENSLACP00000007638	ENSLACP00000000175	Guanylate cyclase activator 1A.	Guanylate cyclase.	0.653
GUCA1A	PDE6G	ENSLACP00000007638	ENSLACP00000019565	Guanylate cyclase activator 1A.	Phosphodiesterase 6G.	0.529
GUCA1A	RD3	ENSLACP00000007638	ENSLACP00000014611	Guanylate cyclase activator 1A.	Retinal degeneration 3, GUCY2D regulator.	0.422
GUCA1A	ROM1	ENSLACP00000007638	ENSLACP00000009339	Guanylate cyclase activator 1A.	Retinal outer segment membrane protein 1.	0.454
GUCA1A	RP1L1	ENSLACP00000007638	ENSLACP00000006929	Guanylate cyclase activator 1A.	Uncharacterized protein.	0.493
GUCA1A	SAG	ENSLACP00000007638	ENSLACP00000003617	Guanylate cyclase activator 1A.	S-antigen visual arrestin.	0.415