(60 nodes) Adherens junction network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	KLHL24	Kelch like family member 24. (596 aa)
	NECTIN3	Nectin cell adhesion molecule 3. (534 aa)
	SSX2IP	SSX family member 2 interacting protein. (495 aa)
	H3B6H9_LATCH	PDZ and pleckstrin homology domains 1. (461 aa)
	LOC102361871	Uncharacterized protein. (1880 aa)
	CTNNB1	Catenin beta 1. (781 aa)
	BMPR2	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1037 aa)
	H3B4X5_LATCH	Uncharacterized protein. (1753 aa)
	CD99L2	CD99 molecule like 2. (246 aa)
	H3B296_LATCH	Uncharacterized protein. (380 aa)
	CCDC85B	Coiled-coil domain containing 85B. (194 aa)
	AFDN	Afadin, adherens junction formation factor. (1854 aa)
	LOC102357889	Uncharacterized protein. (1826 aa)
	CDH5	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (772 aa)
	VCL	Vinculin. (832 aa)
	JAG1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1220 aa)
	PTPRT	Uncharacterized protein. (467 aa)
	KLHL35	Kelch like family member 35. (600 aa)
	H2ZZM1_LATCH	Uncharacterized protein. (323 aa)
	FRMD3	FERM domain containing 3. (552 aa)
	H3A0S5_LATCH	Uncharacterized protein. (547 aa)
	H3A2E9_LATCH	Uncharacterized protein. (196 aa)
	H3A2X0_LATCH	Uncharacterized protein. (278 aa)
	CTNNA3	Uncharacterized protein. (213 aa)
	CCDC85A	Coiled-coil domain containing 85A. (387 aa)
	H3A7V1_LATCH	Uncharacterized protein. (268 aa)
	PTPRT-2	Uncharacterized protein. (357 aa)
	FRS2	Fibroblast growth factor receptor substrate 2. (502 aa)
	MPP7	Membrane palmitoylated protein 7; Belongs to the MAGUK family. (576 aa)
	CDCA3	Uncharacterized protein. (351 aa)
	FRMD5	FERM domain containing 5. (544 aa)
	ADAM10	ADAM metallopeptidase domain 10b. (679 aa)
	ESAM	Endothelial cell adhesion molecule. (428 aa)
	DLL3	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (699 aa)
	LOC102366311	Uncharacterized protein. (501 aa)
	DLL1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (723 aa)
	MAGI1	Membrane associated guanylate kinase, WW and PDZ domain containing 1. (990 aa)
	H3AIF0_LATCH	Ig-like domain-containing protein. (157 aa)
	PTPRM	Protein tyrosine phosphatase receptor type M. (1015 aa)
	NDRG1	N-myc downstream regulated 1. (402 aa)
	MPP4	Membrane palmitoylated protein 4; Belongs to the MAGUK family. (641 aa)
	PGM5	Phosphoglucomutase 5; Belongs to the phosphohexose mutase family. (567 aa)
	H3ARS9_LATCH	Uncharacterized protein. (86 aa)
	NECTIN4	Nectin cell adhesion molecule 4. (469 aa)
	H3AU51_LATCH	Uncharacterized protein. (706 aa)
	LOC102353569	Uncharacterized protein. (205 aa)
	CCDC85C	Coiled-coil domain containing 85C. (225 aa)
	MPP3	Membrane palmitoylated protein 3; Belongs to the MAGUK family. (586 aa)
	CTNNA1	Catenin (cadherin-associated protein), alpha 1. (911 aa)
	LOC102357987	Uncharacterized protein. (2519 aa)
	LOC102358583	Uncharacterized protein. (304 aa)
	VEZT	Vezatin, adherens junctions transmembrane protein. (808 aa)
	ACTN1	Uncharacterized protein. (890 aa)
	ACTN4	Uncharacterized protein. (888 aa)
	CDC42EP4	CDC42 effector protein 4. (321 aa)
	NOTCH1	Notch receptor 1. (2494 aa)
	H3BEX6_LATCH	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (307 aa)
	PLEKHA7	Pleckstrin homology domain containing A7. (1138 aa)
	KLHL6	Kelch like family member 6. (613 aa)
	RND1	Rho family GTPase 1. (321 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTN1	AFDN	ENSLACP00000022097	ENSLACP00000015429	Uncharacterized protein.	Afadin, adherens junction formation factor.	0.427
ACTN1	CTNNA1	ENSLACP00000022097	ENSLACP00000014365	Uncharacterized protein.	Catenin (cadherin-associated protein), alpha 1.	0.925
ACTN1	CTNNB1	ENSLACP00000022097	ENSLACP00000017209	Uncharacterized protein.	Catenin beta 1.	0.440
ACTN1	H3A2E9_LATCH	ENSLACP00000022097	ENSLACP00000003820	Uncharacterized protein.	Uncharacterized protein.	0.925
ACTN1	H3A7V1_LATCH	ENSLACP00000022097	ENSLACP00000005722	Uncharacterized protein.	Uncharacterized protein.	0.925
ACTN1	LOC102366311	ENSLACP00000022097	ENSLACP00000009016	Uncharacterized protein.	Uncharacterized protein.	0.901
ACTN1	VCL	ENSLACP00000022097	ENSLACP00000000289	Uncharacterized protein.	Vinculin.	0.984
ACTN4	VCL	ENSLACP00000021197	ENSLACP00000000289	Uncharacterized protein.	Vinculin.	0.849
ADAM10	DLL1	ENSLACP00000008550	ENSLACP00000009351	ADAM metallopeptidase domain 10b.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.598
ADAM10	DLL3	ENSLACP00000008550	ENSLACP00000008690	ADAM metallopeptidase domain 10b.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.598
ADAM10	JAG1	ENSLACP00000008550	ENSLACP00000001302	ADAM metallopeptidase domain 10b.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.509
ADAM10	LOC102357987	ENSLACP00000008550	ENSLACP00000014598	ADAM metallopeptidase domain 10b.	Uncharacterized protein.	0.616
ADAM10	NOTCH1	ENSLACP00000008550	ENSLACP00000020474	ADAM metallopeptidase domain 10b.	Notch receptor 1.	0.616
AFDN	ACTN1	ENSLACP00000015429	ENSLACP00000022097	Afadin, adherens junction formation factor.	Uncharacterized protein.	0.427
AFDN	CDH5	ENSLACP00000015429	ENSLACP00000012760	Afadin, adherens junction formation factor.	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins.	0.475
AFDN	CTNNA1	ENSLACP00000015429	ENSLACP00000014365	Afadin, adherens junction formation factor.	Catenin (cadherin-associated protein), alpha 1.	0.934
AFDN	CTNNB1	ENSLACP00000015429	ENSLACP00000017209	Afadin, adherens junction formation factor.	Catenin beta 1.	0.539
AFDN	H2ZZM1_LATCH	ENSLACP00000015429	ENSLACP00000002842	Afadin, adherens junction formation factor.	Uncharacterized protein.	0.973
AFDN	H3A2E9_LATCH	ENSLACP00000015429	ENSLACP00000003820	Afadin, adherens junction formation factor.	Uncharacterized protein.	0.934
AFDN	H3A2X0_LATCH	ENSLACP00000015429	ENSLACP00000003991	Afadin, adherens junction formation factor.	Uncharacterized protein.	0.743