(111 nodes) Sarcomere network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	H3AF74_LATCH	Uncharacterized protein. (204 aa)
	LOC106706480	Uncharacterized protein. (213 aa)
	LOC102347576	SH3 domain-containing protein. (2968 aa)
	CAVIN4	Caveolae associated protein 4. (366 aa)
	FHL3	Four and a half LIM domains 3. (287 aa)
	ILK	Integrin linked kinase. (417 aa)
	KLHL40	Kelch like family member 40. (599 aa)
	SYNPO2L	Synaptopodin 2 like. (972 aa)
	LRRC2	Leucine rich repeat containing 2. (367 aa)
	LRRC10	Uncharacterized protein. (244 aa)
	SPHKAP	SPHK1 interactor, AKAP domain containing. (1592 aa)
	TMOD3	Tropomodulin 3. (352 aa)
	H3A5B1_LATCH	Uncharacterized protein. (240 aa)
	PALLD	Palladin, cytoskeletal associated protein. (1438 aa)
	LOC102363383	EF-hand domain-containing protein; Belongs to the S-100 family. (100 aa)
	LDB3	LIM domain binding 3. (589 aa)
	PRRC2B	Proline rich coiled-coil 2B. (2219 aa)
	MYPN	Myopalladin. (1420 aa)
	ACTN3	Actinin alpha 3a. (907 aa)
	H3BEC2_LATCH	Protein phosphatase 1 regulatory subunit. (951 aa)
	H3BGT2_LATCH	Uncharacterized protein. (277 aa)
	TNNC1	Troponin C type 1a (slow). (164 aa)
	LOC102350834	Zgc:109913. (234 aa)
	H3BH85_LATCH	Uncharacterized protein. (164 aa)
	LOC102352170	Uncharacterized protein. (163 aa)
	SMTNL2	Smoothelin, like. (470 aa)
	CAPN3	Calpain 3; Belongs to the peptidase C2 family. (750 aa)
	LOC102351466	Uncharacterized protein. (201 aa)
	MYOM2	Myomesin 2. (962 aa)
	TNNT1	Troponin T1, slow skeletal type. (253 aa)
	ASB2	Ankyrin repeat and SOCS box containing 2. (658 aa)
	SMTNL1	Calponin-homology (CH) domain-containing protein. (388 aa)
	TRIM55	Tripartite motif containing 55. (531 aa)
	TNNI3	Uncharacterized protein. (240 aa)
	SMPX	Small muscle protein X-linked. (85 aa)
	H2ZYM3_LATCH	RING-type domain-containing protein. (81 aa)
	TRIM32	Tripartite motif containing 32. (647 aa)
	H2ZX48_LATCH	Uncharacterized protein. (241 aa)
	PPP1R12C	Protein phosphatase 1 regulatory subunit. (780 aa)
	H2ZWI4_LATCH	Uncharacterized protein. (363 aa)
	CAPN9	Calpain 9; Belongs to the peptidase C2 family. (694 aa)
	H2ZUL3_LATCH	Uncharacterized protein. (225 aa)
	H2ZU79_LATCH	Uncharacterized protein. (236 aa)
	MTMR12	Myotubularin related protein 12. (552 aa)
	MYOZ3	Myozenin 3. (257 aa)
	ACTN2	Actinin alpha 2. (879 aa)
	TRIM63	Tripartite motif containing 63. (354 aa)
	H3B9G5_LATCH	Uncharacterized protein. (251 aa)
	UNC45A	Unc-45 myosin chaperone A. (934 aa)
	CSRP3	Cysteine and glycine rich protein 3. (192 aa)
	SYNC	Syncoilin, intermediate filament protein. (325 aa)
	MYOM3	Myomesin 3. (748 aa)
	IGDCC3	Immunoglobulin superfamily DCC subclass member 3. (654 aa)
	LOC102366172	Uncharacterized protein. (183 aa)
	LOC102365660	Uncharacterized protein. (187 aa)
	LOC102364878	PRKG1_interact domain-containing protein. (409 aa)
	NKX2-5	NK2 homeobox 5. (296 aa)
	PDLIM1	PDZ and LIM domain 1. (325 aa)
	LOC102350553	Uncharacterized protein. (232 aa)
	H3B3H4_LATCH	Uncharacterized protein. (575 aa)
	TMOD1	Tropomodulin 1. (361 aa)
	MTM1	Myotubularin 1. (600 aa)
	PPP1R12A	Protein phosphatase 1 regulatory subunit. (1011 aa)
	LOC102345989	Uncharacterized protein. (92 aa)
	LMOD3	Leiomodin 3. (551 aa)
	CHORDC1	Cysteine and histidine rich domain containing 1. (337 aa)
	LOC102345940	Kyphoscoliosis peptidase. (699 aa)
	TRIM13	Tripartite motif containing 13. (414 aa)
	MYL7	Myosin light chain 7. (182 aa)
	LRRC39	Leucine rich repeat containing 39. (342 aa)
	UNC45B	Unc-45 myosin chaperone B. (676 aa)
	H3AYN1_LATCH	Uncharacterized protein. (1008 aa)
	H3AXK4_LATCH	Myocardial zonula adherens protein. (494 aa)
	H3AXH2_LATCH	Uncharacterized protein. (210 aa)
	LMOD2	Leiomodin 2. (544 aa)
	GGPS1	Geranylgeranyl diphosphate synthase 1; Belongs to the FPP/GGPP synthase family. (338 aa)
	FHL2	Four and a half LIM domains 2. (283 aa)
	LOC102358416	BTB domain-containing protein. (237 aa)
	TMOD4	Tropomodulin 4. (353 aa)
	NEXN	Nexilin F-actin binding protein. (746 aa)
	IGFN1	Immunoglobulin like and fibronectin type III domain containing 1, tandem duplicate 2. (1498 aa)
	PYROXD1	Pyridine nucleotide-disulphide oxidoreductase domain 1. (500 aa)
	ANKRD1	Ankyrin repeat domain 1. (319 aa)
	LMOD1	Leiomodin 1. (603 aa)
	LOC102345580	Uncharacterized protein. (316 aa)
	C10orf71	DUF4585 domain-containing protein. (1398 aa)
	TNNT2	Troponin T2, cardiac type. (286 aa)
	MYOM1	Myomesin 1. (1657 aa)
	PDLIM3	PDZ and LIM domain 3. (356 aa)
	TNNI1	Troponin I1, slow skeletal type. (171 aa)
	ANKRD2	Ankyrin repeat domain 2. (313 aa)
	ITGB1BP2	Integrin subunit beta 1 binding protein 2. (354 aa)
	TNNT3	Troponin T3, fast skeletal type. (227 aa)
	H3AQT8_LATCH	Uncharacterized protein. (223 aa)
	MYOZ2	Myozenin 2. (273 aa)
	LOC102353564	Uncharacterized protein. (161 aa)
	TRIM54	Uncharacterized protein. (366 aa)
	FBXL22	F-box and leucine rich repeat protein 22. (226 aa)
	EVA1C	Uncharacterized protein. (388 aa)
	H3AP16_LATCH	Uncharacterized protein. (239 aa)
	H3ANZ5_LATCH	DNA_pol_B_2 domain-containing protein. (347 aa)
	H3ALZ3_LATCH	Uncharacterized protein. (222 aa)
	KY	Kyphoscoliosis peptidase. (527 aa)
	MYL3	Myosin, light chain 13. (195 aa)
	H3AKU7_LATCH	Uncharacterized protein. (206 aa)
	H3AI48_LATCH	Uncharacterized protein. (205 aa)
	LRRC10B	Leucine rich repeat containing 10B. (278 aa)
	IGSF22	Immunoglobulin superfamily member 22. (1326 aa)
	FHL5	Four and a half LIM domains 5. (284 aa)
	TNNI2	Troponin I2, fast skeletal type. (190 aa)
	H3AFD8_LATCH	Uncharacterized protein. (239 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTN2	CSRP3	ENSLACP00000018992	ENSLACP00000018230	Actinin alpha 2.	Cysteine and glycine rich protein 3.	0.535
ACTN2	H3AXK4_LATCH	ENSLACP00000018992	ENSLACP00000014375	Actinin alpha 2.	Myocardial zonula adherens protein.	0.479
ACTN2	H3AYN1_LATCH	ENSLACP00000018992	ENSLACP00000014752	Actinin alpha 2.	Uncharacterized protein.	0.482
ACTN2	H3BH85_LATCH	ENSLACP00000018992	ENSLACP00000021256	Actinin alpha 2.	Uncharacterized protein.	0.595
ACTN2	IGFN1	ENSLACP00000018992	ENSLACP00000013698	Actinin alpha 2.	Immunoglobulin like and fibronectin type III domain containing 1, tandem duplicate 2.	0.401
ACTN2	IGSF22	ENSLACP00000018992	ENSLACP00000009150	Actinin alpha 2.	Immunoglobulin superfamily member 22.	0.401
ACTN2	LMOD1	ENSLACP00000018992	ENSLACP00000013084	Actinin alpha 2.	Leiomodin 1.	0.459
ACTN2	LOC102347576	ENSLACP00000018992	ENSLACP00000007847	Actinin alpha 2.	SH3 domain-containing protein.	0.548
ACTN2	LOC102350553	ENSLACP00000018992	ENSLACP00000016618	Actinin alpha 2.	Uncharacterized protein.	0.490
ACTN2	LOC102352170	ENSLACP00000018992	ENSLACP00000021261	Actinin alpha 2.	Uncharacterized protein.	0.595
ACTN2	LOC102353564	ENSLACP00000018992	ENSLACP00000011490	Actinin alpha 2.	Uncharacterized protein.	0.491
ACTN2	MYL3	ENSLACP00000018992	ENSLACP00000010304	Actinin alpha 2.	Myosin, light chain 13.	0.590
ACTN2	MYL7	ENSLACP00000018992	ENSLACP00000015156	Actinin alpha 2.	Myosin light chain 7.	0.422
ACTN2	MYOZ2	ENSLACP00000018992	ENSLACP00000011518	Actinin alpha 2.	Myozenin 2.	0.659
ACTN2	MYPN	ENSLACP00000018992	ENSLACP00000019901	Actinin alpha 2.	Myopalladin.	0.519
ACTN2	PALLD	ENSLACP00000018992	ENSLACP00000004803	Actinin alpha 2.	Palladin, cytoskeletal associated protein.	0.519
ACTN2	PDLIM1	ENSLACP00000018992	ENSLACP00000016643	Actinin alpha 2.	PDZ and LIM domain 1.	0.450
ACTN2	PDLIM3	ENSLACP00000018992	ENSLACP00000012442	Actinin alpha 2.	PDZ and LIM domain 3.	0.747
ACTN2	SMPX	ENSLACP00000018992	ENSLACP00000002541	Actinin alpha 2.	Small muscle protein X-linked.	0.613
ACTN2	TMOD1	ENSLACP00000018992	ENSLACP00000016388	Actinin alpha 2.	Tropomodulin 1.	0.501