(60 nodes) Endocytic vesicle network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CORO1B	Coronin; Belongs to the WD repeat coronin family. (414 aa)
	PIP4P1	Phosphatidylinositol-4,5-bisphosphate 4-phosphatase; Catalyzes the hydrolysis of phosphatidylinositol-4,5- bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P). (289 aa)
	AMN	Amnion associated transmembrane protein. (492 aa)
	H3AJS9_LATCH	Uncharacterized protein. (349 aa)
	INPP5B	Inositol polyphosphate-5-phosphatase B. (1012 aa)
	OCRL	OCRL inositol polyphosphate-5-phosphatase. (815 aa)
	SYT7	Synaptotagmin 7. (286 aa)
	TLR6	Toll like receptor 6; Belongs to the Toll-like receptor family. (793 aa)
	LOC102360588	Uncharacterized protein. (214 aa)
	VAMP4	Vesicle associated membrane protein 4. (141 aa)
	RAB20	RAB20, member RAS oncogene family. (235 aa)
	APPL1	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1. (709 aa)
	RAB14	RAB14, member RAS oncogene family. (234 aa)
	LOC102348775	PID domain-containing protein. (282 aa)
	H3AT83_LATCH	SAC domain-containing protein. (359 aa)
	SYK	Tyrosine-protein kinase. (616 aa)
	AP2S1	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (142 aa)
	TLR2	Toll like receptor 2; Belongs to the Toll-like receptor family. (798 aa)
	SLC18A3	Solute carrier family 18 member A3. (530 aa)
	RAB38-2	RAB38b, member of RAS oncogene family. (79 aa)
	EMILIN2	Elastin microfibril interfacer 2. (1045 aa)
	PIKFYVE	Phosphoinositide kinase, FYVE-type zinc finger containing. (2113 aa)
	RAB7B	RAB7B, member RAS oncogene family. (201 aa)
	H3B2K8_LATCH	Uncharacterized protein. (159 aa)
	LOC102350366	TIR domain-containing protein. (789 aa)
	CORO6	Coronin; Belongs to the WD repeat coronin family. (479 aa)
	TLR8	Toll like receptor 8; Belongs to the Toll-like receptor family. (1016 aa)
	AP2A1	Alpha_adaptinC2 domain-containing protein. (737 aa)
	LOC102355189	Toll-like receptor 18; Belongs to the Toll-like receptor family. (797 aa)
	RAB9B	RAB9B, member RAS oncogene family. (213 aa)
	RABEP1	Rabaptin, RAB GTPase binding effector protein 1. (874 aa)
	TLR9	Toll-like receptor 9. (1039 aa)
	RAB35	RAB35, member RAS oncogene family. (203 aa)
	CSF3R	Colony stimulating factor 3 receptor. (826 aa)
	RIN3	Ras and Rab interactor 3. (951 aa)
	H3BIL4_LATCH	PID domain-containing protein. (187 aa)
	INPP5F	Inositol polyphosphate-5-phosphatase F. (874 aa)
	LMBRD1	LMBR1 domain containing 1. (539 aa)
	RAB32	Uncharacterized protein. (174 aa)
	UNC93B1	Unc-93 homolog B1, TLR signaling regulator. (612 aa)
	APPL2	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2. (484 aa)
	RAB38	RAB38b, member of RAS oncogene family. (112 aa)
	ANXA3	Annexin. (323 aa)
	H2ZUT7_LATCH	TIR domain-containing protein. (1060 aa)
	LOC102357859	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (992 aa)
	PIP4P2	Phosphatidylinositol-4,5-bisphosphate 4-phosphatase; Catalyzes the hydrolysis of phosphatidylinositol-4,5- bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P). (257 aa)
	LOC102356101	Uncharacterized protein. (213 aa)
	SCARB2	Scavenger receptor class B member 2; Belongs to the CD36 family. (375 aa)
	LYST	Lysosomal trafficking regulator. (3705 aa)
	RAB23	RAB23, member RAS oncogene family. (237 aa)
	SYT11	Synaptotagmin 11. (429 aa)
	MPEG1	Macrophage expressed 1. (710 aa)
	TLR7	Toll-like receptor 7. (1033 aa)
	CORO1A	Coronin; Belongs to the WD repeat coronin family. (482 aa)
	LOC102363116	TIR domain-containing protein. (141 aa)
	CORO1C	Coronin; Belongs to the WD repeat coronin family. (482 aa)
	LAMP1	Lysosomal associated membrane protein 1. (412 aa)
	H3AC79_LATCH	PID domain-containing protein. (197 aa)
	RAB22A	RAB22A, member RAS oncogene family. (194 aa)
	RAB31	RAB31, member RAS oncogene family. (195 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AP2A1	AP2S1	ENSLACP00000019999	ENSLACP00000014068	Alpha_adaptinC2 domain-containing protein.	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	0.999
AP2A1	APPL1	ENSLACP00000019999	ENSLACP00000012610	Alpha_adaptinC2 domain-containing protein.	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1.	0.413
AP2A1	APPL2	ENSLACP00000019999	ENSLACP00000000307	Alpha_adaptinC2 domain-containing protein.	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2.	0.413
AP2A1	LOC102357859	ENSLACP00000019999	ENSLACP00000001698	Alpha_adaptinC2 domain-containing protein.	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	0.660
AP2A1	OCRL	ENSLACP00000019999	ENSLACP00000010968	Alpha_adaptinC2 domain-containing protein.	OCRL inositol polyphosphate-5-phosphatase.	0.413
AP2A1	SYT11	ENSLACP00000019999	ENSLACP00000004647	Alpha_adaptinC2 domain-containing protein.	Synaptotagmin 11.	0.559
AP2A1	VAMP4	ENSLACP00000019999	ENSLACP00000012409	Alpha_adaptinC2 domain-containing protein.	Vesicle associated membrane protein 4.	0.721
AP2S1	AP2A1	ENSLACP00000014068	ENSLACP00000019999	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	Alpha_adaptinC2 domain-containing protein.	0.999
AP2S1	APPL1	ENSLACP00000014068	ENSLACP00000012610	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1.	0.441
AP2S1	APPL2	ENSLACP00000014068	ENSLACP00000000307	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2.	0.441
AP2S1	LOC102357859	ENSLACP00000014068	ENSLACP00000001698	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	0.998
AP2S1	VAMP4	ENSLACP00000014068	ENSLACP00000012409	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	Vesicle associated membrane protein 4.	0.692
APPL1	AP2A1	ENSLACP00000012610	ENSLACP00000019999	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1.	Alpha_adaptinC2 domain-containing protein.	0.413
APPL1	AP2S1	ENSLACP00000012610	ENSLACP00000014068	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1.	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	0.441
APPL1	APPL2	ENSLACP00000012610	ENSLACP00000000307	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1.	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2.	0.997
APPL1	H3AC79_LATCH	ENSLACP00000012610	ENSLACP00000007250	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1.	PID domain-containing protein.	0.669
APPL1	H3BIL4_LATCH	ENSLACP00000012610	ENSLACP00000021735	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1.	PID domain-containing protein.	0.669
APPL1	INPP5B	ENSLACP00000012610	ENSLACP00000010300	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1.	Inositol polyphosphate-5-phosphatase B.	0.580
APPL1	LOC102348775	ENSLACP00000012610	ENSLACP00000012852	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1.	PID domain-containing protein.	0.669
APPL1	OCRL	ENSLACP00000012610	ENSLACP00000010968	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1.	OCRL inositol polyphosphate-5-phosphatase.	0.691