(162 nodes) Integral component of organelle membrane network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	POLI	DNA polymerase iota. (740 aa)
	DNAJC11	DnaJ heat shock protein family (Hsp40) member C11. (564 aa)
	ZBTB43	Zinc finger and BTB domain containing 43. (433 aa)
	STX6	Syntaxin 6; Belongs to the syntaxin family. (265 aa)
	SPPL2B	Signal peptide peptidase like 2B. (573 aa)
	XXYLT1	Xyloside xylosyltransferase 1. (397 aa)
	SLC37A3	MFS domain-containing protein. (501 aa)
	COX18	Cytochrome c oxidase assembly factor COX18. (333 aa)
	FUNDC2	FUN14 domain containing 2. (168 aa)
	GHITM	Growth hormone inducible transmembrane protein. (354 aa)
	SLC37A2	Solute carrier family 37 member 2. (516 aa)
	PREB	Prolactin regulatory element binding. (424 aa)
	TAP1	Transporter 1, ATP-binding cassette, sub-family B (MDR/TAP). (735 aa)
	COX11	Cytochrome c oxidase copper chaperone COX11. (273 aa)
	STX10	Syntaxin 10. (252 aa)
	TAP2	Transporter associated with antigen processing, subunit type a. (720 aa)
	GDAP1	Ganglioside induced differentiation associated protein 1; Belongs to the GST superfamily. (355 aa)
	ENTPD4	Ectonucleoside triphosphate diphosphohydrolase 4; Belongs to the GDA1/CD39 NTPase family. (481 aa)
	SPG7	SPG7 matrix AAA peptidase subunit, paraplegin. (663 aa)
	SYT4	Synaptotagmin 4. (434 aa)
	PDIA3	Protein disulfide-isomerase. (497 aa)
	SLC17A6	Solute carrier family 17 member 6. (391 aa)
	H2ZRY7_LATCH	Uncharacterized protein. (69 aa)
	IMMT	MICOS complex subunit MIC60; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. (411 aa)
	OMA1	OMA1 zinc metallopeptidase. (358 aa)
	BNIP3	BCL2 interacting protein 3. (202 aa)
	LRRC8E	Leucine rich repeat containing 8 VRAC subunit E. (793 aa)
	FITM2	Fat storage inducing transmembrane protein 2. (266 aa)
	SLC17A7	MFS domain-containing protein. (560 aa)
	ACER3	Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (120 aa)
	GDAP1L1	Ganglioside induced differentiation associated protein 1 like 1. (365 aa)
	COX16	Cytochrome c oxidase assembly factor COX16. (108 aa)
	TMEM201	Transmembrane protein 201. (600 aa)
	RER1	Protein RER1; Involved in the retrieval of endoplasmic reticulum membrane proteins from the early Golgi compartment. (217 aa)
	TMEM70	Transmembrane protein 70. (186 aa)
	CHST12	Carbohydrate sulfotransferase. (419 aa)
	SLC8B1	Solute carrier family 8 member B1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (539 aa)
	WFS1	Wolframin ER transmembrane glycoprotein. (876 aa)
	SLC37A1	Solute carrier family 37 member 1. (390 aa)
	TMEM177	Transmembrane protein 177. (311 aa)
	TECR	Trans-2,3-enoyl-CoA reductase. (166 aa)
	PLEKHG3	Pleckstrin homology and RhoGEF domain containing G3. (1077 aa)
	TMEM175	Transmembrane protein 175. (511 aa)
	MARCHF6	Membrane associated ring-CH-type finger 6. (775 aa)
	COQ2	4-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate. (367 aa)
	STIM1	Stromal interaction molecule 1. (662 aa)
	SYNJ2BP	PDZ domain-containing protein. (107 aa)
	TMEM43	Transmembrane protein 43. (342 aa)
	LOC102357997	Trans-2,3-enoyl-CoA reductase-like 2a. (317 aa)
	SLC27A6	Solute carrier family 27 member 6. (462 aa)
	FUNDC1	FUN14 domain containing 1. (152 aa)
	H3API6_LATCH	Uncharacterized protein. (109 aa)
	H3APB7_LATCH	Mitochondrial E3 ubiquitin protein ligase 1a. (243 aa)
	SGMS1	Sphingomyelin synthase 1. (412 aa)
	ADCK2	AarF domain containing kinase 2. (645 aa)
	LOC102348004	Protein RER1; Involved in the retrieval of endoplasmic reticulum membrane proteins from the early Golgi compartment. (199 aa)
	WDR83OS	WD repeat domain 83 opposite strand. (85 aa)
	ACER2	Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (226 aa)
	GPAA1	Glycosylphosphatidylinositol anchor attachment 1. (626 aa)
	CHCHD6	MICOS complex subunit; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. (246 aa)
	MICOS10	MICOS complex subunit MIC10; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. (76 aa)
	PIGS	Phosphatidylinositol glycan anchor biosynthesis class S. (564 aa)
	TAPBP	Uncharacterized protein. (453 aa)
	TMCO1	Calcium load-activated calcium channel; Calcium-selective channel required to prevent calcium stores from overfilling. (188 aa)
	HM13	Histocompatibility minor 13. (412 aa)
	FICD	FIC domain containing. (458 aa)
	TEX261	Testis expressed 261. (196 aa)
	CREB3	cAMP responsive element binding protein 3. (452 aa)
	ATF6	Activating transcription factor 6. (355 aa)
	SPIRE1	Spire type actin nucleation factor 1. (535 aa)
	ZBTB9	Zinc finger and BTB domain containing 9. (424 aa)
	ITM2B	Integral membrane protein 2B. (260 aa)
	EMC4	ER membrane protein complex subunit 4; Belongs to the EMC4 family. (175 aa)
	H3A9W0_LATCH	AAA domain-containing protein. (747 aa)
	TOMM70	Translocase of outer mitochondrial membrane 70. (601 aa)
	LAMP2	Lysosomal associated membrane protein 2. (416 aa)
	SLC25A45	Solute carrier family 25 member 45; Belongs to the mitochondrial carrier (TC 2.A.29) family. (290 aa)
	CLDN15	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (235 aa)
	LOC102352461	ER membrane protein complex subunit 3; Belongs to the EMC3 family. (260 aa)
	LOC102345511	Uncharacterized protein. (292 aa)
	AFG3L2	AFG3 like matrix AAA peptidase subunit 2. (812 aa)
	CASD1	CAS1 domain containing 1. (800 aa)
	EMC2	ER membrane protein complex subunit 2. (297 aa)
	APOO	MICOS complex subunit; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. (223 aa)
	LOC102349073	Zgc:63863. (409 aa)
	SARAF	Store-operated calcium entry associated regulatory factor. (349 aa)
	TBC1D20	TBC1 domain family member 20. (396 aa)
	ABCB10	ATP binding cassette subfamily B member 10. (723 aa)
	SLC25A17	Solute carrier family 25 member 17; Belongs to the mitochondrial carrier (TC 2.A.29) family. (268 aa)
	LOC102353910	Uncharacterized protein. (191 aa)
	SAMD8	Sterile alpha motif domain containing 8. (470 aa)
	ELOVL4	Elongation of very long chain fatty acids protein. (292 aa)
	P2RX6	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (419 aa)
	OXA1L	OXA1L mitochondrial inner membrane protein. (451 aa)
	ZBTB22	Zinc finger and BTB domain containing 22. (463 aa)
	LOC102353958	Translocating chain-associated membrane protein; Belongs to the TRAM family. (371 aa)
	STEAP2	STEAP2 metalloreductase. (489 aa)
	LOC102346876	Elongation of very long chain fatty acids protein. (265 aa)
	SCO2	SCO cytochrome c oxidase assembly protein 2. (269 aa)
	SPPL2A	Signal peptide peptidase like 2A. (537 aa)
	TRABD2A	TraB domain containing 2A. (193 aa)
	LOC102354722	Uncharacterized protein. (116 aa)
	EMC8	ER membrane protein complex subunit 8. (204 aa)
	LOC106706091	Uncharacterized protein. (503 aa)
	SLC46A3	Solute carrier family 46 member 3. (466 aa)
	PLPP6	Phospholipid phosphatase 6. (279 aa)
	EMC6	ER membrane protein complex subunit 6. (112 aa)
	LOC102350161	Uncharacterized protein. (620 aa)
	TMEM33	Transmembrane protein 33. (245 aa)
	EMC9	ER membrane protein complex subunit 9. (208 aa)
	LOC102348880	KIND domain-containing protein. (635 aa)
	PEX11A	Peroxisomal biogenesis factor 11 alpha. (249 aa)
	SLC27A2	Solute carrier family 27 member 2. (619 aa)
	EMC3	ER membrane protein complex subunit 3; Belongs to the EMC3 family. (261 aa)
	PIGT	Phosphatidylinositol glycan anchor biosynthesis class T. (586 aa)
	PCSK7	Proprotein convertase subtilisin/kexin type 7. (760 aa)
	TPST1	Protein-tyrosine sulfotransferase; Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3'-phosphoadenylyl sulfate (PAPS) as cosubstrate; Belongs to the protein sulfotransferase family. (402 aa)
	SLC15A4	Solute carrier family 15 member 4. (569 aa)
	PIGU	Phosphatidylinositol glycan anchor biosynthesis class U. (435 aa)
	EMC1	ER membrane protein complex subunit 1. (955 aa)
	CHCHD3	MICOS complex subunit; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. (137 aa)
	MUL1	Mitochondrial E3 ubiquitin protein ligase 1. (352 aa)
	PEX2	Peroxisomal biogenesis factor 2. (299 aa)
	PIGK	GPI-anchor transamidase; Mediates GPI anchoring in the endoplasmic reticulum, by replacing a protein's C-terminal GPI attachment signal peptide with a pre-assembled GPI. During this transamidation reaction, the GPI transamidase forms a carbonyl intermediate with the substrate protein. Belongs to the peptidase C13 family. (393 aa)
	INSIG1	Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (251 aa)
	COA3	Cytochrome c oxidase assembly factor 3. (100 aa)
	UBIAD1	UbiA prenyltransferase domain containing 1. (368 aa)
	SCO1	SCO cytochrome c oxidase assembly protein 1. (291 aa)
	SGMS2	Sphingomyelin synthase 2. (264 aa)
	CFAP70	Cilia and flagella associated protein 70. (1141 aa)
	SLC37A4	Solute carrier family 37 member 4. (441 aa)
	M3XLD7_LATCH	Uncharacterized protein. (1155 aa)
	MAJIN	Membrane anchored junction protein. (194 aa)
	SPPL3	Signal peptide peptidase like 3. (385 aa)
	LOC102358019	Uncharacterized protein. (83 aa)
	PEX11B	Peroxisomal biogenesis factor 11 beta. (244 aa)
	ABCB9	ATP binding cassette subfamily B member 9. (779 aa)
	ANKLE2	Ankyrin repeat and LEM domain containing 2. (956 aa)
	PINK1	PTEN induced kinase 1. (467 aa)
	TRAM2	Translocating chain-associated membrane protein; Belongs to the TRAM family. (373 aa)
	BSCL2	BSCL2 lipid droplet biogenesis associated, seipin. (290 aa)
	H3BDM4_LATCH	Uncharacterized protein. (109 aa)
	SLC17A8	Solute carrier family 17 member 8. (439 aa)
	P2RX2	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (388 aa)
	TRAM1	Translocating chain-associated membrane protein; Belongs to the TRAM family. (370 aa)
	PEX12	Peroxisome assembly protein 12; Required for protein import into peroxisomes. Belongs to the pex2/pex10/pex12 family. (356 aa)
	H3BCB4_LATCH	PAP2_C domain-containing protein. (278 aa)
	H3BC72_LATCH	Uncharacterized protein. (193 aa)
	MMGT1	Membrane magnesium transporter 1. (131 aa)
	RHOT1	Mitochondrial Rho GTPase; Mitochondrial GTPase involved in mitochondrial trafficking. Belongs to the mitochondrial Rho GTPase family. (673 aa)
	LEMD2	LEM domain containing 2. (416 aa)
	INSIG2	Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. (239 aa)
	EDEM1	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (654 aa)
	DOLK	Dolichol kinase. (528 aa)
	EMC10	ER membrane protein complex subunit 10. (253 aa)
	ATP13A2	Cation-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. (1091 aa)
	LRRC8A	Leucine rich repeat containing 8 VRAC subunit A. (809 aa)
	RHOT2	Mitochondrial Rho GTPase; Mitochondrial GTPase involved in mitochondrial trafficking. Belongs to the mitochondrial Rho GTPase family. (589 aa)
	P2RX5	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (363 aa)
	MCUR1	Mitochondrial calcium uniporter regulator 1. (382 aa)
	GABRA2	Gamma-aminobutyric acid type A receptor alpha2 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (380 aa)
	PEX3	Peroxisomal biogenesis factor 3. (373 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABCB10	STEAP2	ENSLACP00000004829	ENSLACP00000003884	ATP binding cassette subfamily B member 10.	STEAP2 metalloreductase.	0.694
ABCB10	TAPBP	ENSLACP00000004829	ENSLACP00000010397	ATP binding cassette subfamily B member 10.	Uncharacterized protein.	0.558
ABCB9	LOC106706091	ENSLACP00000020226	ENSLACP00000003447	ATP binding cassette subfamily B member 9.	Uncharacterized protein.	0.418
ABCB9	PDIA3	ENSLACP00000020226	ENSLACP00000015133	ATP binding cassette subfamily B member 9.	Protein disulfide-isomerase.	0.538
ABCB9	TAP2	ENSLACP00000020226	ENSLACP00000015839	ATP binding cassette subfamily B member 9.	Transporter associated with antigen processing, subunit type a.	0.984
ABCB9	TAPBP	ENSLACP00000020226	ENSLACP00000010397	ATP binding cassette subfamily B member 9.	Uncharacterized protein.	0.788
ACER2	H3BCB4_LATCH	ENSLACP00000010881	ENSLACP00000019535	Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.	PAP2_C domain-containing protein.	0.916
ACER2	SGMS1	ENSLACP00000010881	ENSLACP00000011476	Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.	Sphingomyelin synthase 1.	0.916
ACER2	SGMS2	ENSLACP00000010881	ENSLACP00000023178	Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.	Sphingomyelin synthase 2.	0.916
ADCK2	MARCHF6	ENSLACP00000011380	ENSLACP00000012673	AarF domain containing kinase 2.	Membrane associated ring-CH-type finger 6.	0.423
AFG3L2	OMA1	ENSLACP00000005581	ENSLACP00000000842	AFG3 like matrix AAA peptidase subunit 2.	OMA1 zinc metallopeptidase.	0.607
AFG3L2	SPG7	ENSLACP00000005581	ENSLACP00000015254	AFG3 like matrix AAA peptidase subunit 2.	SPG7 matrix AAA peptidase subunit, paraplegin.	0.811
ANKLE2	LEMD2	ENSLACP00000020221	ENSLACP00000018743	Ankyrin repeat and LEM domain containing 2.	LEM domain containing 2.	0.458
APOO	CHCHD3	ENSLACP00000005474	ENSLACP00000001814	MICOS complex subunit; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.	MICOS complex subunit; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.	0.920
APOO	CHCHD6	ENSLACP00000005474	ENSLACP00000010751	MICOS complex subunit; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.	MICOS complex subunit; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.	0.920
APOO	DNAJC11	ENSLACP00000005474	ENSLACP00000017769	MICOS complex subunit; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.	DnaJ heat shock protein family (Hsp40) member C11.	0.605
APOO	IMMT	ENSLACP00000005474	ENSLACP00000000724	MICOS complex subunit; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.	MICOS complex subunit MIC60; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.	0.904
APOO	MICOS10	ENSLACP00000005474	ENSLACP00000010671	MICOS complex subunit; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.	MICOS complex subunit MIC10; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.	0.887
ATF6	CREB3	ENSLACP00000008653	ENSLACP00000008681	Activating transcription factor 6.	cAMP responsive element binding protein 3.	0.502
ATF6	EDEM1	ENSLACP00000008653	ENSLACP00000018295	Activating transcription factor 6.	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family.	0.567