(82 nodes) Apical part of cell network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SAPCD2	Uncharacterized protein. (387 aa)
	H2ZT06_LATCH	Uncharacterized protein. (447 aa)
	ATP1A2	Sodium/potassium-transporting ATPase subunit alpha. (780 aa)
	H2ZUD5_LATCH	Uncharacterized protein. (396 aa)
	LOC102357684	Zgc:110789. (351 aa)
	SUB1	SUB1 regulator of transcription. (65 aa)
	JAG1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1220 aa)
	ABCG2	ABC transporter domain-containing protein. (607 aa)
	H2ZWV6_LATCH	Multidrug and toxin extrusion protein; Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. (494 aa)
	PATJ	PATJ crumbs cell polarity complex component. (2073 aa)
	STK26	Serine/threonine kinase 26. (415 aa)
	SLC6A20	Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (593 aa)
	ENPEP	Aminopeptidase. (952 aa)
	SLC47A1	Multidrug and toxin extrusion protein; Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. (575 aa)
	ATP4A	Sodium/potassium-transporting ATPase subunit alpha. (1033 aa)
	SLC39A14	Solute carrier family 39 member 14. (501 aa)
	SLC6A19	Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (635 aa)
	LOC102348382	DUF4430 domain-containing protein. (427 aa)
	LOC102359917	SEA domain-containing protein. (1102 aa)
	H3A3I5_LATCH	Erythrocyte membrane protein band 4.1 like 4B. (325 aa)
	H3A5I8_LATCH	ABC transporter domain-containing protein. (665 aa)
	SLC26A4	Pendrin; Sodium-independent transporter of chloride and iodide. Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. (771 aa)
	UPK1A	Tetraspanin. (259 aa)
	INSC	INSC spindle orientation adaptor protein. (407 aa)
	H3AA20_LATCH	Uncharacterized protein. (283 aa)
	LOC102355595	Si:dkey-91i10.2. (1049 aa)
	SLCO2B1	Solute carrier organic anion transporter family member. (642 aa)
	CDCP2	CUB domain containing protein 2. (514 aa)
	SLC16A8	Solute carrier family 16 member 8. (513 aa)
	H3AEK5_LATCH	Aquaporin 1a (Colton blood group), tandem duplicate 1; Belongs to the MIP/aquaporin (TC 1.A.8) family. (268 aa)
	SLC12A1	Solute carrier family 12 member 1. (1102 aa)
	SLC23A2	Solute carrier family 23 member 2. (616 aa)
	SLC5A2	Solute carrier family 5 member 2; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (691 aa)
	SLC12A2	Solute carrier family 12 member 2. (1179 aa)
	DLL3	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (699 aa)
	SLC1A1	Amino acid transporter. (523 aa)
	SLC7A1	Solute carrier family 7 member 1. (658 aa)
	H3AI55_LATCH	MFS domain-containing protein. (175 aa)
	DLL1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (723 aa)
	MPDZ	Multiple PDZ domain crumbs cell polarity complex component. (1679 aa)
	SCNN1A	Sodium channel epithelial 1 alpha subunit; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (653 aa)
	GJA1	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (383 aa)
	ADAM17	ADAM metallopeptidase domain 17. (827 aa)
	TEK	TEK receptor tyrosine kinase. (914 aa)
	EMP2	Epithelial membrane protein 2. (160 aa)
	LOC102351006	Kazal-like domain-containing protein. (256 aa)
	SLC12A3	Solute carrier family 12 member 3. (1040 aa)
	CUBN	Cubilin. (2936 aa)
	H3AR10_LATCH	Uncharacterized protein. (571 aa)
	SLC4A11	Solute carrier family 4 member 11. (853 aa)
	SLC23A1	Solute carrier family 23 member 1. (590 aa)
	H3ASP0_LATCH	Uncharacterized protein. (655 aa)
	SCNN1G	Sodium channel epithelial 1 gamma subunit; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (661 aa)
	MORN1	MORN repeat containing 1. (299 aa)
	SCNN1B	Sodium channel epithelial 1 beta subunit; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (650 aa)
	DSTYK	Dual serine/threonine and tyrosine protein kinase. (848 aa)
	AQP8	Aquaporin 8a, tandem duplicate 2; Belongs to the MIP/aquaporin (TC 1.A.8) family. (260 aa)
	LOC102347995	Aldo_ket_red domain-containing protein. (322 aa)
	LOC102357987	Uncharacterized protein. (2519 aa)
	HAX1	HCLS1 associated protein X-1. (249 aa)
	LOC102359345	Transmembrane O-methyltransferase. (268 aa)
	LMO7	LIM domain 7. (1612 aa)
	SLC16A3	Solute carrier family 16 member 3. (479 aa)
	OTOA	Otoancorin. (997 aa)
	CLCN5	Chloride channel protein. (781 aa)
	LOC102355229	Uncharacterized protein. (1401 aa)
	LOC102364897	Solute carrier family 26 member 9; DIDS- and thiosulfate- sensitive anion exchanger mediating chloride, sulfate and oxalate transport. Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. (737 aa)
	SNX10	Sorting nexin 10. (203 aa)
	UPK1B	Tetraspanin. (263 aa)
	H3B6L9_LATCH	Uncharacterized protein. (417 aa)
	ABCC5	ATP binding cassette subfamily C member 5. (1433 aa)
	TASP1	Taspase 1. (301 aa)
	LOC102360278	Uncharacterized protein. (1069 aa)
	H3BAP7_LATCH	Uncharacterized protein. (678 aa)
	RHCG	Rh family C glycoprotein; Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily. (477 aa)
	NOTCH1	Notch receptor 1. (2494 aa)
	SCNN1D	Sodium channel epithelial 1 delta subunit; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (565 aa)
	CD34	Uncharacterized protein. (378 aa)
	CD99	CD99 molecule (Xg blood group). (201 aa)
	LOC102345502	Solute carrier family 26 member 9; DIDS- and thiosulfate- sensitive anion exchanger mediating chloride, sulfate and oxalate transport. Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. (787 aa)
	M3XKD2_LATCH	Uncharacterized protein. (783 aa)
	CFAP126	Cilia and flagella associated protein 126. (304 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABCC5	ABCG2	ENSLACP00000017733	ENSLACP00000001331	ATP binding cassette subfamily C member 5.	ABC transporter domain-containing protein.	0.431
ABCC5	LOC102355229	ENSLACP00000017733	ENSLACP00000016199	ATP binding cassette subfamily C member 5.	Uncharacterized protein.	0.901
ABCG2	ABCC5	ENSLACP00000001331	ENSLACP00000017733	ABC transporter domain-containing protein.	ATP binding cassette subfamily C member 5.	0.431
ABCG2	CD34	ENSLACP00000001331	ENSLACP00000021425	ABC transporter domain-containing protein.	Uncharacterized protein.	0.423
ABCG2	H3A5I8_LATCH	ENSLACP00000001331	ENSLACP00000004909	ABC transporter domain-containing protein.	ABC transporter domain-containing protein.	0.901
ADAM17	LOC102357987	ENSLACP00000010665	ENSLACP00000014598	ADAM metallopeptidase domain 17.	Uncharacterized protein.	0.488
ADAM17	NOTCH1	ENSLACP00000010665	ENSLACP00000020474	ADAM metallopeptidase domain 17.	Notch receptor 1.	0.488
AQP8	H3AEK5_LATCH	ENSLACP00000014505	ENSLACP00000008076	Aquaporin 8a, tandem duplicate 2; Belongs to the MIP/aquaporin (TC 1.A.8) family.	Aquaporin 1a (Colton blood group), tandem duplicate 1; Belongs to the MIP/aquaporin (TC 1.A.8) family.	0.726
ATP4A	LOC102348382	ENSLACP00000003227	ENSLACP00000003805	Sodium/potassium-transporting ATPase subunit alpha.	DUF4430 domain-containing protein.	0.499
CD34	ABCG2	ENSLACP00000021425	ENSLACP00000001331	Uncharacterized protein.	ABC transporter domain-containing protein.	0.423
CD34	CD99	ENSLACP00000021425	ENSLACP00000022759	Uncharacterized protein.	CD99 molecule (Xg blood group).	0.543
CD34	TEK	ENSLACP00000021425	ENSLACP00000011084	Uncharacterized protein.	TEK receptor tyrosine kinase.	0.464
CD99	CD34	ENSLACP00000022759	ENSLACP00000021425	CD99 molecule (Xg blood group).	Uncharacterized protein.	0.543
CLCN5	CUBN	ENSLACP00000016146	ENSLACP00000012042	Chloride channel protein.	Cubilin.	0.552
CUBN	CLCN5	ENSLACP00000012042	ENSLACP00000016146	Cubilin.	Chloride channel protein.	0.552
CUBN	LOC102348382	ENSLACP00000012042	ENSLACP00000003805	Cubilin.	DUF4430 domain-containing protein.	0.593
DLL1	DLL3	ENSLACP00000009351	ENSLACP00000008690	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.904
DLL1	JAG1	ENSLACP00000009351	ENSLACP00000001302	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.524
DLL1	LOC102357987	ENSLACP00000009351	ENSLACP00000014598	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Uncharacterized protein.	0.984
DLL1	NOTCH1	ENSLACP00000009351	ENSLACP00000020474	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Notch receptor 1.	0.848