(148 nodes) PDZ domain network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	RHPN1	Rhophilin Rho GTPase binding protein 1. (606 aa)
	PRX	Periaxin. (1446 aa)
	TAX1BP3	Tax1 binding protein 3. (123 aa)
	PDZD3	PDZ domain containing 3. (459 aa)
	CARD14	Caspase recruitment domain family member 14. (996 aa)
	H3BDY0_LATCH	PDZ domain-containing protein. (885 aa)
	PCLO	Piccolo presynaptic cytomatrix protein. (4033 aa)
	H3BBQ1_LATCH	Uncharacterized protein. (1715 aa)
	INTU	Inturned planar cell polarity protein. (960 aa)
	GIPC1	GIPC PDZ domain containing family member 1. (333 aa)
	DLG1	Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (928 aa)
	CNKSR1	Connector enhancer of kinase suppressor of Ras 1. (838 aa)
	MAGI3	Membrane associated guanylate kinase, WW and PDZ domain containing 3. (1514 aa)
	SNTB1	Syntrophin beta 1. (521 aa)
	USH1C	USH1 protein network component harmonin. (830 aa)
	H3B7M0_LATCH	Uncharacterized protein. (428 aa)
	ERBIN	Erbb2 interacting protein. (1413 aa)
	H3B6H9_LATCH	PDZ and pleckstrin homology domains 1. (461 aa)
	GRID2IP	Grid2 interacting protein. (1023 aa)
	GIPC3	GIPC PDZ domain containing family member 3. (319 aa)
	PARD3	Par-3 family cell polarity regulator. (1214 aa)
	LNX2	Ligand of numb-protein X 2. (735 aa)
	H3B4C9_LATCH	PDZ domain-containing protein. (105 aa)
	SLC9A3R1	SLC9A3 regulator 1. (389 aa)
	PDLIM1	PDZ and LIM domain 1. (325 aa)
	DVL2	Dishevelled segment polarity protein 2. (401 aa)
	DVL3	Dishevelled segment polarity protein 3. (716 aa)
	PDZD11	PDZ domain containing 11. (142 aa)
	PARD6A	Par-6 family cell polarity regulator alpha. (307 aa)
	PTPN13	Tyrosine-protein phosphatase non-receptor type 13; Regulates negatively FAS-induced apoptosis and NGFR-mediated pro-apoptotic signaling. (2480 aa)
	PREX1	Phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1. (1161 aa)
	MPP2	Membrane palmitoylated protein 2; Belongs to the MAGUK family. (460 aa)
	TJP3	Tight junction protein 3; Belongs to the MAGUK family. (859 aa)
	IL16	Pro-interleukin-16; Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4. (1208 aa)
	APBA3	Amyloid beta precursor protein binding family A member 3. (462 aa)
	SHROOM4	Shroom family member 4. (1398 aa)
	MPP1	Membrane palmitoylated protein 1; Belongs to the MAGUK family. (477 aa)
	PDZRN4	PDZ domain containing ring finger 4. (790 aa)
	LOC102353477	Si:ch211-250n8.1. (429 aa)
	PTPN4	PDZ domain-containing protein. (308 aa)
	AFDN	Afadin, adherens junction formation factor. (1854 aa)
	STXBP4	Syntaxin binding protein 4. (703 aa)
	PDZD8	PDZ domain containing 8. (770 aa)
	RIMS1	Regulating synaptic membrane exocytosis 1. (1125 aa)
	LMO7	LIM domain 7. (1612 aa)
	DLG4	Discs large MAGUK scaffold protein 4; Belongs to the MAGUK family. (828 aa)
	GIPC2	GIPC PDZ domain containing family member 2. (327 aa)
	CNKSR3	Uncharacterized protein. (551 aa)
	PDZRN3	PDZ domain containing ring finger 3. (757 aa)
	LNX1	Ligand of numb-protein X 1. (732 aa)
	MAGI2	Uncharacterized protein. (397 aa)
	LOC102354048	Si:dkeyp-97e7.9. (312 aa)
	DEPTOR	DEP domain containing MTOR interacting protein. (369 aa)
	MAST1	Microtubule associated serine/threonine kinase 1. (1491 aa)
	LIN7C	Protein lin-7 homolog; Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells; Belongs to the lin-7 family. (200 aa)
	MPP3	Membrane palmitoylated protein 3; Belongs to the MAGUK family. (586 aa)
	SIPA1	Signal-induced proliferation-associated 1. (1204 aa)
	TIAM1	T cell lymphoma invasion and metastasis 1. (1606 aa)
	LIN7A	Lin-7 homolog A, crumbs cell polarity complex component. (168 aa)
	LOC102364024	Ligand of numb-protein X 2b. (690 aa)
	HTRA2	HtrA serine peptidase 2. (525 aa)
	TJP2	Tight junction protein 2a (zona occludens 2). (1241 aa)
	LOC102365688	Protein phosphatase 1 regulatory subunit 9A-like B. (908 aa)
	SNTA1	Syntrophin alpha 1. (481 aa)
	PDLIM3	PDZ and LIM domain 3. (356 aa)
	SYNJ2BP	PDZ domain-containing protein. (107 aa)
	TIAM2	T cell lymphoma invasion and metastasis 2. (1727 aa)
	H3AR23_LATCH	PDZ domain-containing protein. (98 aa)
	HTRA3	HtrA serine peptidase 3. (460 aa)
	H3AQM8_LATCH	Uncharacterized protein. (311 aa)
	SDCBP2	Uncharacterized protein. (300 aa)
	MPP4	Membrane palmitoylated protein 4; Belongs to the MAGUK family. (641 aa)
	MAST2	Microtubule associated serine/threonine kinase 2. (1415 aa)
	CASK	Calcium/calmodulin dependent serine protein kinase; Belongs to the MAGUK family. (692 aa)
	HTRA1	HtrA serine peptidase 1. (477 aa)
	MPP5	Membrane palmitoylated protein 5; Belongs to the MAGUK family. (678 aa)
	MYO18A	Myosin XVIIIA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2468 aa)
	RAPGEF2	Rap guanine nucleotide exchange factor 2. (1514 aa)
	H3ALU1_LATCH	Uncharacterized protein. (1358 aa)
	ARHGEF12	Rho guanine nucleotide exchange factor 12. (1565 aa)
	H3AKJ4_LATCH	PDZ domain-containing protein. (1300 aa)
	RIMS2-2	Regulating synaptic membrane exocytosis 2. (817 aa)
	PDLIM5	PDZ and LIM domain 5. (629 aa)
	MPDZ	Multiple PDZ domain crumbs cell polarity complex component. (1679 aa)
	PARD6B	Par-6 family cell polarity regulator beta. (369 aa)
	MAGI1	Membrane associated guanylate kinase, WW and PDZ domain containing 1. (990 aa)
	MPP6	Uncharacterized protein; Belongs to the MAGUK family. (540 aa)
	CYTIP	Cytohesin 1 interacting protein. (371 aa)
	H3AEM2_LATCH	Si:dkeyp-72e1.9. (684 aa)
	RADIL	Rap associating with DIL domain. (850 aa)
	NOS1	Nitric oxide synthase 1. (1476 aa)
	GOPC	Golgi-associated PDZ and coiled-coil motif containing. (456 aa)
	RHPN2	Rhophilin Rho GTPase binding protein 2. (684 aa)
	H3ACT9_LATCH	PDZ domain-containing protein. (264 aa)
	PICK1	Protein interacting with PRKCA 1. (409 aa)
	PDZK1	PDZ domain containing 1. (523 aa)
	MPP7	Membrane palmitoylated protein 7; Belongs to the MAGUK family. (576 aa)
	PREX2	Phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2. (1418 aa)
	MAST3	Microtubule associated serine/threonine kinase 3. (1299 aa)
	H3A9U0_LATCH	PDZ domain-containing protein. (234 aa)
	FRMPD3	FERM and PDZ domain containing 3. (1702 aa)
	MAST4	Microtubule associated serine/threonine kinase family member 4. (1298 aa)
	SYNPO2L	Synaptopodin 2 like. (972 aa)
	SIPA1L2	Signal induced proliferation associated 1 like 2. (1665 aa)
	DLG5	Discs large MAGUK scaffold protein 5; Belongs to the MAGUK family. (1821 aa)
	H3A6Z5_LATCH	PDZ domain-containing protein. (230 aa)
	SDCBP	Syndecan binding protein. (242 aa)
	ARHGAP21	Rho GTPase activating protein 21. (1978 aa)
	LOC102349972	Uncharacterized protein. (246 aa)
	SHANK3	SH3 and multiple ankyrin repeat domains 3. (1187 aa)
	LDB3	LIM domain binding 3. (589 aa)
	GRIP2	Glutamate receptor interacting protein 2. (1064 aa)
	H3A478_LATCH	PDZ domain-containing protein. (297 aa)
	CARD10	Caspase recruitment domain family member 10. (1063 aa)
	RGS12	PDZ domain-containing protein. (629 aa)
	PARD3B	Uncharacterized protein. (1094 aa)
	PTPN3	Tyrosine-protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class subfamily. (871 aa)
	H3A2W7_LATCH	PDZ domain-containing protein. (139 aa)
	CNKSR2	Connector enhancer of kinase suppressor of Ras 2. (805 aa)
	SHANK1	SH3 and multiple ankyrin repeat domains 1. (1849 aa)
	PPP1R9A	Protein phosphatase 1 regulatory subunit 9A. (1320 aa)
	HTRA4	HtrA serine peptidase 4. (461 aa)
	ARHGEF11	Rho guanine nucleotide exchange factor 11. (1546 aa)
	H2ZZI0_LATCH	PDZ domain containing 2. (2484 aa)
	SNX27	Sorting nexin 27. (559 aa)
	PATJ	PATJ crumbs cell polarity complex component. (2073 aa)
	H2ZVR4_LATCH	Uncharacterized protein. (1061 aa)
	PDZD7	PDZ domain containing 7. (505 aa)
	SIPA1L1	Signal induced proliferation associated 1 like 1. (1414 aa)
	GRIP1	Glutamate receptor interacting protein 1. (938 aa)
	H2ZS03_LATCH	PDZ domain-containing protein. (143 aa)
	APBA1	Amyloid beta precursor protein binding family A member 1. (812 aa)
	SHROOM2	Shroom family member 2. (1749 aa)
	LOC102357035	Si:ch73-281f12.4. (1167 aa)
	PDZD9	PDZ domain containing 9. (288 aa)
	DLG3	Discs large MAGUK scaffold protein 3; Belongs to the MAGUK family. (901 aa)
	PDLIM7	PDZ and LIM domain 7. (427 aa)
	PPP1R9B	Protein phosphatase 1 regulatory subunit 9B. (857 aa)
	GRASP	General receptor for phosphoinositides 1 associated scaffold protein. (357 aa)
	DVL1	Dishevelled segment polarity protein 1. (552 aa)
	SIPA1L3	Signal induced proliferation associated 1 like 3. (1798 aa)
	LIMK1	LIM domain kinase 1. (613 aa)
	TJP1	Tight junction protein 1; Belongs to the MAGUK family. (1782 aa)
	APBA2	Amyloid beta precursor protein binding family A member 2. (757 aa)
	PSMD9	Proteasome 26S subunit, non-ATPase 9. (210 aa)
	RAPGEF6	Uncharacterized protein. (1491 aa)
	ARHGAP23	Rho GTPase activating protein 23. (1813 aa)
	LIN7B	Protein lin-7 homolog; Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells; Belongs to the lin-7 family. (208 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AFDN	LMO7	ENSLACP00000015429	ENSLACP00000015131	Afadin, adherens junction formation factor.	LIM domain 7.	0.519
AFDN	PDZD11	ENSLACP00000015429	ENSLACP00000016307	Afadin, adherens junction formation factor.	PDZ domain containing 11.	0.604
AFDN	RAPGEF2	ENSLACP00000015429	ENSLACP00000010647	Afadin, adherens junction formation factor.	Rap guanine nucleotide exchange factor 2.	0.487
AFDN	RAPGEF6	ENSLACP00000015429	ENSLACP00000020816	Afadin, adherens junction formation factor.	Uncharacterized protein.	0.470
AFDN	SIPA1L1	ENSLACP00000015429	ENSLACP00000000601	Afadin, adherens junction formation factor.	Signal induced proliferation associated 1 like 1.	0.434
AFDN	SIPA1L2	ENSLACP00000015429	ENSLACP00000005625	Afadin, adherens junction formation factor.	Signal induced proliferation associated 1 like 2.	0.534
AFDN	TJP1	ENSLACP00000015429	ENSLACP00000021216	Afadin, adherens junction formation factor.	Tight junction protein 1; Belongs to the MAGUK family.	0.982
AFDN	TJP2	ENSLACP00000015429	ENSLACP00000013056	Afadin, adherens junction formation factor.	Tight junction protein 2a (zona occludens 2).	0.981
AFDN	TJP3	ENSLACP00000015429	ENSLACP00000015979	Afadin, adherens junction formation factor.	Tight junction protein 3; Belongs to the MAGUK family.	0.749
APBA1	CARD10	ENSLACP00000023158	ENSLACP00000004260	Amyloid beta precursor protein binding family A member 1.	Caspase recruitment domain family member 10.	0.434
APBA1	CARD14	ENSLACP00000023158	ENSLACP00000020181	Amyloid beta precursor protein binding family A member 1.	Caspase recruitment domain family member 14.	0.434
APBA1	CASK	ENSLACP00000023158	ENSLACP00000011437	Amyloid beta precursor protein binding family A member 1.	Calcium/calmodulin dependent serine protein kinase; Belongs to the MAGUK family.	0.998
APBA1	DLG1	ENSLACP00000023158	ENSLACP00000018954	Amyloid beta precursor protein binding family A member 1.	Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family.	0.434
APBA1	DLG3	ENSLACP00000023158	ENSLACP00000022891	Amyloid beta precursor protein binding family A member 1.	Discs large MAGUK scaffold protein 3; Belongs to the MAGUK family.	0.434
APBA1	DLG4	ENSLACP00000023158	ENSLACP00000015101	Amyloid beta precursor protein binding family A member 1.	Discs large MAGUK scaffold protein 4; Belongs to the MAGUK family.	0.434
APBA1	DLG5	ENSLACP00000023158	ENSLACP00000005485	Amyloid beta precursor protein binding family A member 1.	Discs large MAGUK scaffold protein 5; Belongs to the MAGUK family.	0.452
APBA1	H3BDY0_LATCH	ENSLACP00000023158	ENSLACP00000020101	Amyloid beta precursor protein binding family A member 1.	PDZ domain-containing protein.	0.535
APBA1	LIN7A	ENSLACP00000023158	ENSLACP00000013268	Amyloid beta precursor protein binding family A member 1.	Lin-7 homolog A, crumbs cell polarity complex component.	0.710
APBA1	LIN7B	ENSLACP00000023158	ENSLACP00000020422	Amyloid beta precursor protein binding family A member 1.	Protein lin-7 homolog; Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells; Belongs to the lin-7 family.	0.710
APBA1	LIN7C	ENSLACP00000023158	ENSLACP00000013471	Amyloid beta precursor protein binding family A member 1.	Protein lin-7 homolog; Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells; Belongs to the lin-7 family.	0.710