(147 nodes) Small GTPase network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC102350273	Uncharacterized protein. (196 aa)
	RAB22A	RAB22A, member RAS oncogene family. (194 aa)
	RAB31	RAB31, member RAS oncogene family. (195 aa)
	RAB6B	Uncharacterized protein. (186 aa)
	H3AGN2_LATCH	Uncharacterized protein. (687 aa)
	RABL6	RAB, member RAS oncogene family like 6. (360 aa)
	RAB33A	RAB33A, member RAS oncogene family. (235 aa)
	RAB13	Uncharacterized protein. (178 aa)
	H3AJ41_LATCH	Rho related BTB domain containing 4. (642 aa)
	LOC102352152	Uncharacterized protein. (206 aa)
	REM1	RRAD and GEM like GTPase 1. (300 aa)
	RAB44	Uncharacterized protein. (687 aa)
	RHOQ	Ras homolog family member Q. (205 aa)
	RAB18	RAB18A, member RAS oncogene family. (206 aa)
	RAB5C	RAB5C, member RAS oncogene family. (216 aa)
	MRAS	Uncharacterized protein. (208 aa)
	RND2	Rho family GTPase 2. (238 aa)
	H3APB0_LATCH	Uncharacterized protein. (231 aa)
	ARHGAP35	Rho GTPase activating protein 35b. (1487 aa)
	RAB12	RAB12, member RAS oncogene family. (270 aa)
	RASEF	RAS and EF-hand domain containing. (709 aa)
	H3ARU2_LATCH	Uncharacterized protein. (152 aa)
	LOC102360588	Uncharacterized protein. (214 aa)
	RAB20	RAB20, member RAS oncogene family. (235 aa)
	RAB25	RAB25, member RAS oncogene family. (214 aa)
	LOC102363400	RAS-like, family 11, member A. (250 aa)
	RAB14	RAB14, member RAS oncogene family. (234 aa)
	RHOH	Ras homolog family member H. (189 aa)
	LOC102352866	RAB18B, member RAS oncogene family. (205 aa)
	LOC102357106	RAB11a, member RAS oncogene family, like. (217 aa)
	RAP1B	RAP1B, member of RAS oncogene family. (184 aa)
	LOC102358164	Zgc:101559. (231 aa)
	RAB24	RAB24, member RAS oncogene family. (203 aa)
	LOC102362077	Ras homolog gene family, member Gc. (192 aa)
	RHEB	Ras homolog, mTORC1 binding. (184 aa)
	RAB11A	RAB11A, member RAS oncogene family. (215 aa)
	RAB8B	RAB8B, member RAS oncogene family. (206 aa)
	RRAD	RRAD, Ras related glycolysis inhibitor and calcium channel regulator. (306 aa)
	RHOD	Uncharacterized protein. (212 aa)
	RAB3A	RAB3A, member RAS oncogene family. (158 aa)
	RAB38	RAB38b, member of RAS oncogene family. (112 aa)
	RAD54B	Uncharacterized protein. (2005 aa)
	RAB34	RAB34, member RAS oncogene family. (259 aa)
	RHOT2	Mitochondrial Rho GTPase; Mitochondrial GTPase involved in mitochondrial trafficking. Belongs to the mitochondrial Rho GTPase family. (589 aa)
	DIRAS1	DIRAS family GTPase 1. (198 aa)
	H2ZVL2_LATCH	Uncharacterized protein. (208 aa)
	ARHGAP5	Rho GTPase activating protein 5. (1303 aa)
	NKIRAS1	NFKB inhibitor interacting Ras like 1. (191 aa)
	LOC102356101	Uncharacterized protein. (213 aa)
	RASD1	Ras related dexamethasone induced 1. (265 aa)
	RAB29	RAB29, member RAS oncogene family. (206 aa)
	DIRAS2	DIRAS family GTPase 2. (199 aa)
	RAB43	RAB43, member RAS oncogene family. (213 aa)
	LOC102347078	ArfGAP with GTPase domain, ankyrin repeat and PH domain 3. (265 aa)
	RAB2A	RAB2A, member RAS oncogene family. (212 aa)
	LOC102348731	RAB42, member RAS oncogene family. (210 aa)
	RAB1B	RAB1B, member RAS oncogene family. (203 aa)
	LOC102349001	Uncharacterized protein. (212 aa)
	RAB1A	RAB1A, member RAS oncogene family. (229 aa)
	RHOG	Ras homolog family member G. (191 aa)
	DNAJC27	DnaJ heat shock protein family (Hsp40) member C27. (273 aa)
	RASL11A	RAS like family 11 member A. (236 aa)
	RRAS2	RAS related 2. (202 aa)
	RAC1	Rac family small GTPase 1. (192 aa)
	RAB27B	RAB27B, member RAS oncogene family. (220 aa)
	RAB33B	RAB33B, member RAS oncogene family. (230 aa)
	RAB41	RAB41, member RAS oncogene family. (211 aa)
	LOC102346868	Uncharacterized protein. (744 aa)
	RAB27A	RAB27A, member RAS oncogene family. (221 aa)
	RAB3D	RAB3D, member RAS oncogene family. (223 aa)
	RAB7B	RAB7B, member RAS oncogene family. (201 aa)
	H3B2K8_LATCH	Uncharacterized protein. (159 aa)
	CPLANE2	Ciliogenesis and planar polarity effector 2. (266 aa)
	RAB2B	RAB2B, member RAS oncogene family. (165 aa)
	RAB40C	RAB40C, member RAS oncogene family. (282 aa)
	LOC102360575	Si:dkey-27j5.5. (267 aa)
	RAP2B	RAP2B, member of RAS oncogene family. (183 aa)
	RAB37	Uncharacterized protein. (192 aa)
	RAB19	RAB19, member RAS oncogene family. (260 aa)
	RALB	RAS like proto-oncogene B. (225 aa)
	RAB7A	RAB7A, member RAS oncogene family. (207 aa)
	CDC42	Cell division cycle 42. (156 aa)
	RAB39B	Uncharacterized protein. (213 aa)
	RAP2A	RAP2A, member of RAS oncogene family. (183 aa)
	CRACR2A	Uncharacterized protein. (316 aa)
	RHOT1	Mitochondrial Rho GTPase; Mitochondrial GTPase involved in mitochondrial trafficking. Belongs to the mitochondrial Rho GTPase family. (673 aa)
	REM2	RRAD and GEM like GTPase 2. (295 aa)
	RND1	Rho family GTPase 1. (321 aa)
	LOC102363089	RAB11B, member RAS oncogene family, b. (228 aa)
	RASL12	RAS like family 12. (278 aa)
	RHOA	Uncharacterized protein. (193 aa)
	LOC102356108	Uncharacterized protein. (208 aa)
	RAB11B	RAB11B, member RAS oncogene family. (172 aa)
	GPX2	Glutathione peroxidase 2. (307 aa)
	RRAS	RAS related. (174 aa)
	RASL10B	RAS like family 10 member B. (202 aa)
	RHOU	Ras homolog family member Ub. (243 aa)
	LOC102348346	Rasd family member 4. (208 aa)
	RABL2A	RAB, member of RAS oncogene family-like 2. (225 aa)
	RAB23	RAB23, member RAS oncogene family. (237 aa)
	RND3	Rho family GTPase 3. (244 aa)
	LOC102348524	Uncharacterized protein. (193 aa)
	RERGL	RERG like. (208 aa)
	RAB5A	RAB5A, member RAS oncogene family. (230 aa)
	RHOV	Ras homolog family member V. (241 aa)
	RAP2C	Uncharacterized protein. (183 aa)
	RAB6A	RAB6A, member RAS oncogene family. (210 aa)
	RIT1	Ras like without CAAX 1. (228 aa)
	RHOBTB3	Rho related BTB domain containing 3. (608 aa)
	LOC102351732	Uncharacterized protein. (192 aa)
	RHOBTB1	Rho related BTB domain containing 1. (637 aa)
	RALA	RAS like proto-oncogene A. (206 aa)
	RASL10A	RAS-like, family 10, member A. (203 aa)
	LOC102366232	RAB5B, member RAS oncogene family. (213 aa)
	RAB10	RAB10, member RAS oncogene family. (201 aa)
	RASD2	RASD family member 2. (271 aa)
	RAB30	RAB30, member RAS oncogene family. (203 aa)
	RAB32	Uncharacterized protein. (174 aa)
	LOC102352006	Uncharacterized protein. (163 aa)
	RERG	RAS like estrogen regulated growth inhibitor. (140 aa)
	KRAS	KRAS proto-oncogene, GTPase. (189 aa)
	RAB26	Uncharacterized protein. (102 aa)
	LOC102348662	Uncharacterized protein. (199 aa)
	RHOBTB2	Rho related BTB domain containing 2. (734 aa)
	RAC3	Rac family small GTPase 3. (148 aa)
	RAB28	Uncharacterized protein. (221 aa)
	RHEBL1	Ras homolog, mTORC1 binding like 1. (184 aa)
	RAB5B	RAB5B, member RAS oncogene family. (229 aa)
	RAN	GTP-binding nuclear protein Ran; GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle. Belongs to the small GTPase superfamily. Ran family. (147 aa)
	LOC102360186	Uncharacterized protein. (218 aa)
	RAP1A	RAP1A, member of RAS oncogene family b. (185 aa)
	RAB35	RAB35, member RAS oncogene family. (203 aa)
	NRAS	NRAS proto-oncogene, GTPase. (189 aa)
	HRAS	HRas proto-oncogene, GTPase. (193 aa)
	RHOF	Ras homolog family member F, filopodia associated. (187 aa)
	AGAP2	ArfGAP with GTPase domain, ankyrin repeat and PH domain 2. (796 aa)
	H3BFE2_LATCH	Si:dkeyp-59c12.1. (224 aa)
	RHOC	Ras homolog family member Cb. (156 aa)
	RAB9B	RAB9B, member RAS oncogene family. (213 aa)
	RAB8A	RAB8A, member RAS oncogene family. (598 aa)
	H3BEM0_LATCH	RAB4B, member RAS oncogene family. (222 aa)
	RAB3C	RAB3C, member RAS oncogene family. (225 aa)
	RAB36	RAB36, member RAS oncogene family. (268 aa)
	LOC102352289	Zgc:64022. (225 aa)
	RHOJ	Ras homolog family member J. (136 aa)
	IFT27	Intraflagellar transport 27. (186 aa)
	DIRAS3	Uncharacterized protein. (197 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARHGAP35	ARHGAP5	ENSLACP00000011704	ENSLACP00000001682	Rho GTPase activating protein 35b.	Rho GTPase activating protein 5.	0.901
ARHGAP35	CDC42	ENSLACP00000011704	ENSLACP00000018010	Rho GTPase activating protein 35b.	Cell division cycle 42.	0.673
ARHGAP35	H3ARU2_LATCH	ENSLACP00000011704	ENSLACP00000012363	Rho GTPase activating protein 35b.	Uncharacterized protein.	0.417
ARHGAP35	HRAS	ENSLACP00000011704	ENSLACP00000020973	Rho GTPase activating protein 35b.	HRas proto-oncogene, GTPase.	0.417
ARHGAP35	KRAS	ENSLACP00000011704	ENSLACP00000022976	Rho GTPase activating protein 35b.	KRAS proto-oncogene, GTPase.	0.417
ARHGAP35	LOC102348524	ENSLACP00000011704	ENSLACP00000004714	Rho GTPase activating protein 35b.	Uncharacterized protein.	0.980
ARHGAP35	LOC102350273	ENSLACP00000011704	ENSLACP00000007743	Rho GTPase activating protein 35b.	Uncharacterized protein.	0.815
ARHGAP35	LOC102351732	ENSLACP00000011704	ENSLACP00000006235	Rho GTPase activating protein 35b.	Uncharacterized protein.	0.469
ARHGAP35	LOC102362077	ENSLACP00000011704	ENSLACP00000013451	Rho GTPase activating protein 35b.	Ras homolog gene family, member Gc.	0.503
ARHGAP35	NRAS	ENSLACP00000011704	ENSLACP00000020975	Rho GTPase activating protein 35b.	NRAS proto-oncogene, GTPase.	0.417
ARHGAP35	RAC1	ENSLACP00000011704	ENSLACP00000015032	Rho GTPase activating protein 35b.	Rac family small GTPase 1.	0.469
ARHGAP35	RAC3	ENSLACP00000011704	ENSLACP00000022054	Rho GTPase activating protein 35b.	Rac family small GTPase 3.	0.469
ARHGAP35	RHOA	ENSLACP00000011704	ENSLACP00000019259	Rho GTPase activating protein 35b.	Uncharacterized protein.	0.980
ARHGAP35	RHOC	ENSLACP00000011704	ENSLACP00000020380	Rho GTPase activating protein 35b.	Ras homolog family member Cb.	0.815
ARHGAP35	RHOD	ENSLACP00000011704	ENSLACP00000014143	Rho GTPase activating protein 35b.	Uncharacterized protein.	0.608
ARHGAP35	RHOF	ENSLACP00000011704	ENSLACP00000020946	Rho GTPase activating protein 35b.	Ras homolog family member F, filopodia associated.	0.608
ARHGAP35	RHOG	ENSLACP00000011704	ENSLACP00000014649	Rho GTPase activating protein 35b.	Ras homolog family member G.	0.503
ARHGAP35	RHOH	ENSLACP00000011704	ENSLACP00000012746	Rho GTPase activating protein 35b.	Ras homolog family member H.	0.400
ARHGAP35	RHOJ	ENSLACP00000011704	ENSLACP00000020233	Rho GTPase activating protein 35b.	Ras homolog family member J.	0.465
ARHGAP35	RHOQ	ENSLACP00000011704	ENSLACP00000010548	Rho GTPase activating protein 35b.	Ras homolog family member Q.	0.465