(44 nodes) Low-density lipoprotein (LDL) receptor class A repeat network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	RXFP2	Relaxin family peptide receptor 2. (763 aa)
	NETO1	Neuropilin and tolloid like 1. (385 aa)
	H3AJF8_LATCH	Peptidase S1 domain-containing protein. (483 aa)
	LRP3	LDL receptor related protein 3. (692 aa)
	MALRD1	MAM and LDL receptor class A domain containing 1. (1285 aa)
	LDLRAD4	Low density lipoprotein receptor class A domain containing 4. (310 aa)
	SORL1	Sortilin-related receptor, L(DLR class) A repeats containing. (1410 aa)
	LOC102348686	Uncharacterized protein. (591 aa)
	H3AUC5_LATCH	Uncharacterized protein. (1812 aa)
	MALRD1-2	Uncharacterized protein. (274 aa)
	LDLRAD3	Low density lipoprotein receptor class A domain containing 3. (328 aa)
	C8B	Complement C8 beta chain. (619 aa)
	C8A	Complement C8 alpha chain. (581 aa)
	LDLR	Low density lipoprotein receptor. (851 aa)
	H3B4N7_LATCH	Uncharacterized protein. (343 aa)
	TMPRSS9	Transmembrane serine protease 9; Belongs to the peptidase S1 family. (707 aa)
	TMPRSS2	Transmembrane serine protease 2; Belongs to the peptidase S1 family. (487 aa)
	MFRP	Membrane frizzled-related protein. (588 aa)
	C6	Complement C6. (841 aa)
	CORIN	Corin, serine peptidase. (753 aa)
	LRP1B	Uncharacterized protein. (1007 aa)
	LRP12	LDL receptor related protein 12. (534 aa)
	LDLRAD2	Low density lipoprotein receptor class A domain containing 2. (369 aa)
	LRP10	LDL receptor related protein 10. (543 aa)
	ST14	Suppressor of tumorigenicity 14 protein homolog; Degrades extracellular matrix. (845 aa)
	LRP6	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1615 aa)
	LRP1	LDL receptor related protein 1. (4329 aa)
	LRP5	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1598 aa)
	LOC102360524	Uncharacterized protein; Belongs to the peptidase S1 family. (454 aa)
	LRP4	LDL receptor related protein 4. (1896 aa)
	LRP2	LDL receptor related protein 2. (4649 aa)
	C9	Complement C9. (623 aa)
	VLDLR	Very low density lipoprotein receptor. (885 aa)
	CFI	Uncharacterized protein; Belongs to the peptidase S1 family. (597 aa)
	M3XL62_LATCH	Uncharacterized protein. (269 aa)
	LRP8	LDL receptor related protein 8. (842 aa)
	H2ZXM4_LATCH	EGF-like domain-containing protein. (580 aa)
	MAMDC4	Uncharacterized protein. (1157 aa)
	LOC102354865	Uncharacterized protein. (746 aa)
	NETO2	Neuropilin and tolloid like 2. (521 aa)
	H3A4J9_LATCH	Si:dkey-88l16.3. (1142 aa)
	TMPRSS7	Transmembrane serine protease 7. (829 aa)
	DGCR2	DiGeorge syndrome critical region gene 2. (554 aa)
	TMPRSS6	Transmembrane serine protease 6; Belongs to the peptidase S1 family. (781 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C6	C8A	ENSLACP00000000511	ENSLACP00000016041	Complement C6.	Complement C8 alpha chain.	0.608
C6	C8B	ENSLACP00000000511	ENSLACP00000015711	Complement C6.	Complement C8 beta chain.	0.637
C6	C9	ENSLACP00000000511	ENSLACP00000022478	Complement C6.	Complement C9.	0.749
C8A	C6	ENSLACP00000016041	ENSLACP00000000511	Complement C8 alpha chain.	Complement C6.	0.608
C8A	C8B	ENSLACP00000016041	ENSLACP00000015711	Complement C8 alpha chain.	Complement C8 beta chain.	0.809
C8A	C9	ENSLACP00000016041	ENSLACP00000022478	Complement C8 alpha chain.	Complement C9.	0.970
C8B	C6	ENSLACP00000015711	ENSLACP00000000511	Complement C8 beta chain.	Complement C6.	0.637
C8B	C8A	ENSLACP00000015711	ENSLACP00000016041	Complement C8 beta chain.	Complement C8 alpha chain.	0.809
C8B	C9	ENSLACP00000015711	ENSLACP00000022478	Complement C8 beta chain.	Complement C9.	0.726
C9	C6	ENSLACP00000022478	ENSLACP00000000511	Complement C9.	Complement C6.	0.749
C9	C8A	ENSLACP00000022478	ENSLACP00000016041	Complement C9.	Complement C8 alpha chain.	0.970
C9	C8B	ENSLACP00000022478	ENSLACP00000015711	Complement C9.	Complement C8 beta chain.	0.726
C9	CFI	ENSLACP00000022478	ENSLACP00000023323	Complement C9.	Uncharacterized protein; Belongs to the peptidase S1 family.	0.565
CFI	C9	ENSLACP00000023323	ENSLACP00000022478	Uncharacterized protein; Belongs to the peptidase S1 family.	Complement C9.	0.565
H3AJF8_LATCH	M3XL62_LATCH	ENSLACP00000009779	ENSLACP00000023468	Peptidase S1 domain-containing protein.	Uncharacterized protein.	0.586
LOC102354865	M3XL62_LATCH	ENSLACP00000003641	ENSLACP00000023468	Uncharacterized protein.	Uncharacterized protein.	0.586
LOC102360524	M3XL62_LATCH	ENSLACP00000021213	ENSLACP00000023468	Uncharacterized protein; Belongs to the peptidase S1 family.	Uncharacterized protein.	0.420
LRP5	LRP6	ENSLACP00000021154	ENSLACP00000020844	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	0.990
LRP6	LRP5	ENSLACP00000020844	ENSLACP00000021154	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	0.990
M3XL62_LATCH	H3AJF8_LATCH	ENSLACP00000023468	ENSLACP00000009779	Uncharacterized protein.	Peptidase S1 domain-containing protein.	0.586