(44 nodes) p53-like transcription factor, DNA-binding domain superfamily network (Latimeria chalumnae)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC102354410	RHD domain-containing protein. (185 aa)
	NFATC3	Nuclear factor of activated T cells 3. (1027 aa)
	NFATC1	Nuclear factor of activated T cells 1. (455 aa)
	TBX5	T-box transcription factor 5. (522 aa)
	H2ZZK6_LATCH	RHD domain-containing protein. (272 aa)
	MGA	MAX dimerization protein MGA. (2907 aa)
	LOC102348150	Signal transducer and activator of transcription. (786 aa)
	NFKB1	Nuclear factor kappa B subunit 1. (969 aa)
	EOMES	Eomesodermin. (419 aa)
	NFAT5	Nuclear factor of activated T cells 5. (1531 aa)
	TBR1	T-box brain transcription factor 1. (673 aa)
	TBX6	Uncharacterized protein. (101 aa)
	LOC102357940	Uncharacterized protein. (440 aa)
	RBPJL	Recombination signal binding protein for immunoglobulin kappa J region like. (512 aa)
	TBX3	T-box transcription factor 3. (713 aa)
	TBX22	T-box transcription factor 22. (509 aa)
	STAT1	Signal transducer and activator of transcription. (1179 aa)
	RBPJ	Recombination signal binding protein for immunoglobulin kappa J region. (487 aa)
	TBX15	T-box transcription factor 15. (566 aa)
	H3AHH6_LATCH	RHD domain-containing protein. (288 aa)
	REL	REL proto-oncogene, NF-kB subunit. (593 aa)
	TBX19	T-box transcription factor 19. (373 aa)
	MYRFL	Myelin regulatory factor like. (718 aa)
	TBX20	T-box transcription factor 20. (441 aa)
	LOC102365298	Uncharacterized protein. (427 aa)
	RUNX2	Runt-related transcription factor. (452 aa)
	STAT3	Signal transducer and activator of transcription. (763 aa)
	LOC102345533	T-box transcription factor 16. (438 aa)
	H3B111_LATCH	V-rel avian reticuloendotheliosis viral oncogene homolog A. (203 aa)
	RUNX3	RUNX family transcription factor 3. (179 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (401 aa)
	TBX4	T-box transcription factor 4. (541 aa)
	TBX2	T-box transcription factor 2. (689 aa)
	TBXT	T-box transcription factor T. (434 aa)
	RUNX1	Runt domain-containing protein. (191 aa)
	TBX18	T-box transcription factor 18. (568 aa)
	NFKB2	Nuclear factor kappa B subunit 2. (914 aa)
	TBX1	T-box transcription factor 1. (457 aa)
	MYRF	Myelin regulatory factor. (1122 aa)
	TBX21	T-box transcription factor 21. (570 aa)
	STAT2	Signal transducer and activator of transcription. (765 aa)
	TP73	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (636 aa)
	TP63	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (637 aa)
	NFATC2	Nuclear factor of activated T cells 2. (912 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EOMES	LOC102365298	ENSLACP00000003120	ENSLACP00000012531	Eomesodermin.	Uncharacterized protein.	0.601
EOMES	TBX19	ENSLACP00000003120	ENSLACP00000010044	Eomesodermin.	T-box transcription factor 19.	0.599
EOMES	TBX21	ENSLACP00000003120	ENSLACP00000019310	Eomesodermin.	T-box transcription factor 21.	0.546
EOMES	TBXT	ENSLACP00000003120	ENSLACP00000017539	Eomesodermin.	T-box transcription factor T.	0.598
H3B111_LATCH	NFKB1	ENSLACP00000015582	ENSLACP00000003071	V-rel avian reticuloendotheliosis viral oncogene homolog A.	Nuclear factor kappa B subunit 1.	0.842
H3B111_LATCH	NFKB2	ENSLACP00000015582	ENSLACP00000018524	V-rel avian reticuloendotheliosis viral oncogene homolog A.	Nuclear factor kappa B subunit 2.	0.842
H3B111_LATCH	STAT3	ENSLACP00000015582	ENSLACP00000013656	V-rel avian reticuloendotheliosis viral oncogene homolog A.	Signal transducer and activator of transcription.	0.761
LOC102345533	RBPJ	ENSLACP00000014635	ENSLACP00000008245	T-box transcription factor 16.	Recombination signal binding protein for immunoglobulin kappa J region.	0.433
LOC102348150	NFAT5	ENSLACP00000002957	ENSLACP00000003642	Signal transducer and activator of transcription.	Nuclear factor of activated T cells 5.	0.448
LOC102348150	STAT1	ENSLACP00000002957	ENSLACP00000007692	Signal transducer and activator of transcription.	Signal transducer and activator of transcription.	0.700
LOC102348150	STAT2	ENSLACP00000002957	ENSLACP00000021655	Signal transducer and activator of transcription.	Signal transducer and activator of transcription.	0.726
LOC102348150	STAT3	ENSLACP00000002957	ENSLACP00000013656	Signal transducer and activator of transcription.	Signal transducer and activator of transcription.	0.941
LOC102348150	TP53	ENSLACP00000002957	ENSLACP00000015915	Signal transducer and activator of transcription.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.409
LOC102354410	NFATC1	ENSLACP00000000625	ENSLACP00000001999	RHD domain-containing protein.	Nuclear factor of activated T cells 1.	0.900
LOC102354410	NFATC2	ENSLACP00000000625	ENSLACP00000022961	RHD domain-containing protein.	Nuclear factor of activated T cells 2.	0.661
LOC102354410	NFATC3	ENSLACP00000000625	ENSLACP00000001488	RHD domain-containing protein.	Nuclear factor of activated T cells 3.	0.536
LOC102365298	EOMES	ENSLACP00000012531	ENSLACP00000003120	Uncharacterized protein.	Eomesodermin.	0.601
LOC102365298	TBR1	ENSLACP00000012531	ENSLACP00000004379	Uncharacterized protein.	T-box brain transcription factor 1.	0.499
NFAT5	LOC102348150	ENSLACP00000003642	ENSLACP00000002957	Nuclear factor of activated T cells 5.	Signal transducer and activator of transcription.	0.448
NFAT5	STAT2	ENSLACP00000003642	ENSLACP00000021655	Nuclear factor of activated T cells 5.	Signal transducer and activator of transcription.	0.437