(134 nodes) Growth factor receptor cysteine-rich domain superfamily network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	C8A	Complement C8 alpha chain. (581 aa)
	SLIT3	Slit guidance ligand 3. (635 aa)
	LOC102345355	Uncharacterized protein. (276 aa)
	PCSK4	Proprotein convertase subtilisin/kexin type 4; Belongs to the peptidase S8 family. (768 aa)
	VLDLR	Very low density lipoprotein receptor. (885 aa)
	IGFBP2	Insulin like growth factor binding protein 2. (279 aa)
	LOC102363870	TNFR-Cys domain-containing protein. (348 aa)
	NOTCH2	Notch receptor 2. (2489 aa)
	LRP2	LDL receptor related protein 2. (4649 aa)
	H3BIJ1_LATCH	Uncharacterized protein. (538 aa)
	MEGF6	Multiple EGF like domains 6. (1397 aa)
	FBLN5	Fibulin 5. (436 aa)
	CRB2	Uncharacterized protein. (1473 aa)
	LRP4	LDL receptor related protein 4. (1896 aa)
	H3BHF5_LATCH	Uncharacterized protein. (848 aa)
	LRP1	LDL receptor related protein 1. (4329 aa)
	LRP6	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1615 aa)
	PCSK6	Proprotein convertase subtilisin/kexin type 6; Belongs to the peptidase S8 family. (799 aa)
	VWCE	Von Willebrand factor C and EGF domains. (620 aa)
	LOC102364760	Uncharacterized protein. (986 aa)
	NOTCH1	Notch receptor 1. (2494 aa)
	GPR179	Si:ch211-156l18.8. (1012 aa)
	H3BES4_LATCH	Uncharacterized protein. (558 aa)
	H3BEP8_LATCH	Uncharacterized protein. (556 aa)
	CD93	CD93 molecule. (592 aa)
	LOC102361865	Zgc:158328. (1352 aa)
	CCN1	Cellular communication network factor 1. (368 aa)
	SCUBE2	Signal peptide, CUB domain and EGF like domain containing 2. (991 aa)
	KIAA1324	KIAA1324. (825 aa)
	NELL2	Neural EGFL like 2. (715 aa)
	RSPO1	R-spondin 1. (249 aa)
	LTBP4	Latent transforming growth factor beta binding protein 4. (1535 aa)
	IGFBP6	Insulin like growth factor binding protein 6. (271 aa)
	H3BAK8_LATCH	EGF-like domain-containing protein. (174 aa)
	H3BAG9_LATCH	Uncharacterized protein. (255 aa)
	H3BA69_LATCH	Si:ch73-330k17.3. (196 aa)
	NID2	Nidogen 2. (1537 aa)
	SCUBE1	CUB domain-containing protein. (357 aa)
	CRELD1	Cysteine rich with EGF like domains 1. (338 aa)
	H3B8Y7_LATCH	Uncharacterized protein. (1543 aa)
	FBN3	Fibrillin 3. (2803 aa)
	LOC102366945	Uncharacterized protein. (258 aa)
	FBLN1	Fibulin-1; Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes. (701 aa)
	H3B644_LATCH	Uncharacterized protein. (954 aa)
	FURIN	Furin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family. (801 aa)
	SCUBE3	Signal peptide, CUB domain and EGF like domain containing 3. (958 aa)
	ERBB2	Receptor protein-tyrosine kinase. (1250 aa)
	CCN6	Cellular communication network factor 6. (354 aa)
	PROS1	Protein S. (677 aa)
	EGFL6	EGF like domain multiple 6. (526 aa)
	GAS6	Uncharacterized protein. (681 aa)
	EPHB3	EPH receptor B3. (996 aa)
	HMCN1	Uncharacterized protein. (5440 aa)
	H3AYV3_LATCH	Uncharacterized protein. (962 aa)
	EFEMP2	EGF containing fibulin extracellular matrix protein 2. (446 aa)
	JAG2	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1106 aa)
	LOC102357987	Uncharacterized protein. (2519 aa)
	SNED1	Sushi, nidogen and EGF like domains 1. (980 aa)
	FAT1	FAT atypical cadherin 1. (3389 aa)
	VWA2	Von Willebrand factor A domain containing 2. (763 aa)
	FRAS1	Uncharacterized protein. (630 aa)
	H3AUQ7_LATCH	Si:dkey-163f14.6. (718 aa)
	LOC102351251	Uncharacterized protein. (305 aa)
	EPHA2	Uncharacterized protein. (979 aa)
	KIAA1324L	KIAA1324 like. (965 aa)
	LOC102363594	Uncharacterized protein. (372 aa)
	CRTAC1	Cartilage acidic protein 1. (633 aa)
	HTRA4	HtrA serine peptidase 4. (461 aa)
	LOC102350164	Uncharacterized protein. (364 aa)
	H3A1D6_LATCH	Uncharacterized protein. (1979 aa)
	NOTCH3	Notch receptor 3. (1577 aa)
	SCARF2	Scavenger receptor class F member 2. (821 aa)
	H3A383_LATCH	Uncharacterized protein. (154 aa)
	ERBB4-2	Protein kinase domain-containing protein. (789 aa)
	CCN5	Cellular communication network factor 5. (329 aa)
	H3A4U8_LATCH	Uncharacterized protein. (2171 aa)
	ESM1	Endothelial cell specific molecule 1. (185 aa)
	MEGF8	Multiple EGF like domains 8. (2553 aa)
	EPHA10	Uncharacterized protein. (732 aa)
	H3A7N7_LATCH	GF_recep_IV domain-containing protein. (99 aa)
	NPNT	Nephronectin. (583 aa)
	H3A9E2_LATCH	Uncharacterized protein. (1114 aa)
	EPHB6	EPH receptor B6. (974 aa)
	DNER	Delta/notch like EGF repeat containing. (644 aa)
	LOC102354119	G_PROTEIN_RECEP_F3_4 domain-containing protein. (869 aa)
	CRB1	Crumbs cell polarity complex component 1. (1366 aa)
	RSPO4	R-spondin 4. (184 aa)
	CD248	CD248 molecule, endosialin a. (550 aa)
	H3ACJ0_LATCH	Cellular communication network factor 2b. (348 aa)
	SVEP1	Sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1. (3259 aa)
	LOC102351448	Uncharacterized protein. (5563 aa)
	CCN3	Cellular communication network factor 3. (345 aa)
	IGF1R	Insulin like growth factor 1 receptor. (1170 aa)
	IGFBP5	Insulin like growth factor binding protein 5. (279 aa)
	DLL3	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (699 aa)
	CRELD2	Cysteine rich with EGF like domains 2. (362 aa)
	LTBR	Lymphotoxin beta receptor. (377 aa)
	MATN2-2	Uncharacterized protein. (476 aa)
	DLL1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (723 aa)
	LOC102358409	Uncharacterized protein. (534 aa)
	RSPO3	R-spondin 3. (213 aa)
	H3AJ94_LATCH	Si:dkey-235d18.5. (641 aa)
	MATN2	Matrilin 2. (531 aa)
	FBN1	Fibrillin 1. (2872 aa)
	TNFRSF9	TNF receptor superfamily member 9. (213 aa)
	CCN4	Cellular communication network factor 4. (357 aa)
	KAZALD1	Kazal type serine peptidase inhibitor domain 1. (302 aa)
	H3AML2_LATCH	Uncharacterized protein. (627 aa)
	EFEMP1	EGF containing fibulin extracellular matrix protein 1. (323 aa)
	INSR	Uncharacterized protein. (270 aa)
	HTRA1	HtrA serine peptidase 1. (477 aa)
	H3APJ9_LATCH	Proprotein convertase subtilisin/kexin type 5b. (616 aa)
	FAT4	FAT atypical cadherin 4. (3207 aa)
	HTRA3	HtrA serine peptidase 3. (460 aa)
	LTBP1	Latent transforming growth factor beta binding protein 1. (1433 aa)
	FBLN2	Fibulin 2. (1176 aa)
	LOC102351101	Uncharacterized protein. (792 aa)
	H3ATN8_LATCH	Si:ch211-186j3.6; Cadherins are calcium-dependent cell adhesion proteins. (2519 aa)
	H2ZRI0_LATCH	Uncharacterized protein. (277 aa)
	LOC102353790	Uncharacterized protein. (899 aa)
	CCN2	Cellular communication network factor 2. (344 aa)
	LOC102352108	Uncharacterized protein. (271 aa)
	JAG1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1220 aa)
	H2ZVE3_LATCH	Uncharacterized protein. (238 aa)
	LOC102367052	Uncharacterized protein. (446 aa)
	LOC102353315	Uncharacterized protein. (381 aa)
	LRP1B	Uncharacterized protein. (1007 aa)
	ERBB3	Protein kinase domain-containing protein. (1047 aa)
	IGFBP3	Insulin like growth factor binding protein 3. (288 aa)
	LRP8	LDL receptor related protein 8. (842 aa)
	H2ZXM4_LATCH	EGF-like domain-containing protein. (580 aa)
	H2ZZ43_LATCH	Uncharacterized protein. (815 aa)
	TLL2	Metalloendopeptidase. (899 aa)
	FBN2	Uncharacterized protein. (2561 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CCN1	CCN2	ENSLACP00000019670	ENSLACP00000000493	Cellular communication network factor 1.	Cellular communication network factor 2.	0.565
CCN2	CCN1	ENSLACP00000000493	ENSLACP00000019670	Cellular communication network factor 2.	Cellular communication network factor 1.	0.565
CCN2	FBN1	ENSLACP00000000493	ENSLACP00000010136	Cellular communication network factor 2.	Fibrillin 1.	0.467
CCN2	H3ACJ0_LATCH	ENSLACP00000000493	ENSLACP00000007361	Cellular communication network factor 2.	Cellular communication network factor 2b.	0.902
CCN2	LOC102350164	ENSLACP00000000493	ENSLACP00000003199	Cellular communication network factor 2.	Uncharacterized protein.	0.570
CCN2	LOC102353315	ENSLACP00000000493	ENSLACP00000001383	Cellular communication network factor 2.	Uncharacterized protein.	0.486
DLL1	DLL3	ENSLACP00000009351	ENSLACP00000008690	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.904
DLL1	H3AML2_LATCH	ENSLACP00000009351	ENSLACP00000010883	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Uncharacterized protein.	0.579
DLL1	JAG1	ENSLACP00000009351	ENSLACP00000001302	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.524
DLL1	JAG2	ENSLACP00000009351	ENSLACP00000014617	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.417
DLL1	LOC102353790	ENSLACP00000009351	ENSLACP00000000182	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Uncharacterized protein.	0.974
DLL1	LOC102357987	ENSLACP00000009351	ENSLACP00000014598	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Uncharacterized protein.	0.984
DLL1	NOTCH1	ENSLACP00000009351	ENSLACP00000020474	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Notch receptor 1.	0.848
DLL1	NOTCH2	ENSLACP00000009351	ENSLACP00000022069	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Notch receptor 2.	0.962
DLL1	NOTCH3	ENSLACP00000009351	ENSLACP00000003701	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Notch receptor 3.	0.974
DLL3	DLL1	ENSLACP00000008690	ENSLACP00000009351	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.904
DLL3	H3AML2_LATCH	ENSLACP00000008690	ENSLACP00000010883	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Uncharacterized protein.	0.579
DLL3	JAG1	ENSLACP00000008690	ENSLACP00000001302	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.486
DLL3	LOC102353790	ENSLACP00000008690	ENSLACP00000000182	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Uncharacterized protein.	0.973
DLL3	LOC102357987	ENSLACP00000008690	ENSLACP00000014598	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Uncharacterized protein.	0.984