(18 nodes) Four-helical cytokine-like, core network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LEP	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family. (169 aa)
	H3ALZ2_LATCH	Uncharacterized protein. (108 aa)
	LOC102349296	Uncharacterized protein. (218 aa)
	H3A3C0_LATCH	Uncharacterized protein. (176 aa)
	LOC102364515	Uncharacterized protein. (221 aa)
	EPO	Erythropoietin. (179 aa)
	CLCF1	Cardiotrophin like cytokine factor 1. (235 aa)
	H3A664_LATCH	Uncharacterized protein. (188 aa)
	H3A6V0_LATCH	Uncharacterized protein. (190 aa)
	IL10	Interleukin 10. (185 aa)
	H3AGE1_LATCH	Uncharacterized protein. (211 aa)
	CTF1	Cardiotrophin 1. (183 aa)
	IL6	Uncharacterized protein. (149 aa)
	CNTF	Uncharacterized protein. (206 aa)
	LOC102356247	Uncharacterized protein. (636 aa)
	CSF3	Colony stimulating factor 3. (210 aa)
	H3B4D3_LATCH	Somatolactin alpha. (235 aa)
	PRL	Prolactin. (231 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CLCF1	CNTF	ENSLACP00000001155	ENSLACP00000022760	Cardiotrophin like cytokine factor 1.	Uncharacterized protein.	0.833
CLCF1	CTF1	ENSLACP00000001155	ENSLACP00000008923	Cardiotrophin like cytokine factor 1.	Cardiotrophin 1.	0.476
CNTF	CLCF1	ENSLACP00000022760	ENSLACP00000001155	Uncharacterized protein.	Cardiotrophin like cytokine factor 1.	0.833
CNTF	CTF1	ENSLACP00000022760	ENSLACP00000008923	Uncharacterized protein.	Cardiotrophin 1.	0.554
CNTF	H3A6V0_LATCH	ENSLACP00000022760	ENSLACP00000005371	Uncharacterized protein.	Uncharacterized protein.	0.600
CNTF	IL6	ENSLACP00000022760	ENSLACP00000009318	Uncharacterized protein.	Uncharacterized protein.	0.653
CSF3	EPO	ENSLACP00000016938	ENSLACP00000022768	Colony stimulating factor 3.	Erythropoietin.	0.572
CSF3	IL10	ENSLACP00000016938	ENSLACP00000005382	Colony stimulating factor 3.	Interleukin 10.	0.589
CSF3	IL6	ENSLACP00000016938	ENSLACP00000009318	Colony stimulating factor 3.	Uncharacterized protein.	0.824
CSF3	LOC102356247	ENSLACP00000016938	ENSLACP00000022371	Colony stimulating factor 3.	Uncharacterized protein.	0.601
CTF1	CLCF1	ENSLACP00000008923	ENSLACP00000001155	Cardiotrophin 1.	Cardiotrophin like cytokine factor 1.	0.476
CTF1	CNTF	ENSLACP00000008923	ENSLACP00000022760	Cardiotrophin 1.	Uncharacterized protein.	0.554
CTF1	H3A6V0_LATCH	ENSLACP00000008923	ENSLACP00000005371	Cardiotrophin 1.	Uncharacterized protein.	0.531
CTF1	IL6	ENSLACP00000008923	ENSLACP00000009318	Cardiotrophin 1.	Uncharacterized protein.	0.408
EPO	CSF3	ENSLACP00000022768	ENSLACP00000016938	Erythropoietin.	Colony stimulating factor 3.	0.572
H3A3C0_LATCH	H3A664_LATCH	ENSLACP00000004141	ENSLACP00000005135	Uncharacterized protein.	Uncharacterized protein.	0.571
H3A3C0_LATCH	IL10	ENSLACP00000004141	ENSLACP00000005382	Uncharacterized protein.	Interleukin 10.	0.601
H3A664_LATCH	H3A3C0_LATCH	ENSLACP00000005135	ENSLACP00000004141	Uncharacterized protein.	Uncharacterized protein.	0.571
H3A664_LATCH	IL10	ENSLACP00000005135	ENSLACP00000005382	Uncharacterized protein.	Interleukin 10.	0.717
H3A664_LATCH	IL6	ENSLACP00000005135	ENSLACP00000009318	Uncharacterized protein.	Uncharacterized protein.	0.556