(30 nodes) EGF-like, conserved site network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	H3BAG9_LATCH	Uncharacterized protein. (255 aa)
	JAG1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1220 aa)
	H2ZZ43_LATCH	Uncharacterized protein. (815 aa)
	H3A1M2_LATCH	Uncharacterized protein. (1602 aa)
	NOTCH3	Notch receptor 3. (1577 aa)
	DLK2	Delta like non-canonical Notch ligand 2. (340 aa)
	SLIT1	Slit guidance ligand 1. (925 aa)
	CRB1	Crumbs cell polarity complex component 1. (1366 aa)
	SVEP1	Sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1. (3259 aa)
	VWDE	Von Willebrand factor D and EGF domains. (673 aa)
	DLL1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (723 aa)
	H3AJ94_LATCH	Si:dkey-235d18.5. (641 aa)
	FBN1	Fibrillin 1. (2872 aa)
	H3AML2_LATCH	Uncharacterized protein. (627 aa)
	MEGF10	Multiple EGF like domains 10. (1124 aa)
	SLIT2	Slit guidance ligand 2. (1372 aa)
	MEGF11	Multiple EGF like domains 11. (963 aa)
	WIF1	WNT inhibitory factor 1. (379 aa)
	H3ATN8_LATCH	Si:ch211-186j3.6; Cadherins are calcium-dependent cell adhesion proteins. (2519 aa)
	LOC102353790	Uncharacterized protein. (899 aa)
	SLIT3	Slit guidance ligand 3. (635 aa)
	NOTCH2	Notch receptor 2. (2489 aa)
	MEGF6	Multiple EGF like domains 6. (1397 aa)
	NOTCH1	Notch receptor 1. (2494 aa)
	CELSR2	Cadherin EGF LAG seven-pass G-type receptor 2; Belongs to the G-protein coupled receptor 2 family. (2952 aa)
	NCAN	Uncharacterized protein. (266 aa)
	SNED1	Sushi, nidogen and EGF like domains 1. (980 aa)
	LOC102357987	Uncharacterized protein. (2519 aa)
	JAG2	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1106 aa)
	FBN3	Fibrillin 3. (2803 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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structured XML interaction data, according to the 'PSI-MI' data standard

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node degree of proteins in your network (given the current score cut-off)

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a flat-file format describing the coordinates and colors of nodes in the network

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DLL1	H3AML2_LATCH	ENSLACP00000009351	ENSLACP00000010883	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Uncharacterized protein.	0.579
DLL1	JAG1	ENSLACP00000009351	ENSLACP00000001302	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.524
DLL1	JAG2	ENSLACP00000009351	ENSLACP00000014617	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.417
DLL1	LOC102353790	ENSLACP00000009351	ENSLACP00000000182	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Uncharacterized protein.	0.974
DLL1	LOC102357987	ENSLACP00000009351	ENSLACP00000014598	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Uncharacterized protein.	0.984
DLL1	NOTCH1	ENSLACP00000009351	ENSLACP00000020474	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Notch receptor 1.	0.848
DLL1	NOTCH2	ENSLACP00000009351	ENSLACP00000022069	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Notch receptor 2.	0.962
DLL1	NOTCH3	ENSLACP00000009351	ENSLACP00000003701	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Notch receptor 3.	0.974
FBN1	FBN3	ENSLACP00000010136	ENSLACP00000018340	Fibrillin 1.	Fibrillin 3.	0.707
FBN3	FBN1	ENSLACP00000018340	ENSLACP00000010136	Fibrillin 3.	Fibrillin 1.	0.707
H3AJ94_LATCH	MEGF10	ENSLACP00000009715	ENSLACP00000012108	Si:dkey-235d18.5.	Multiple EGF like domains 10.	0.604
H3AJ94_LATCH	MEGF11	ENSLACP00000009715	ENSLACP00000012462	Si:dkey-235d18.5.	Multiple EGF like domains 11.	0.733
H3AML2_LATCH	DLL1	ENSLACP00000010883	ENSLACP00000009351	Uncharacterized protein.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.579
H3AML2_LATCH	JAG1	ENSLACP00000010883	ENSLACP00000001302	Uncharacterized protein.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.713
H3AML2_LATCH	JAG2	ENSLACP00000010883	ENSLACP00000014617	Uncharacterized protein.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.680
JAG1	DLL1	ENSLACP00000001302	ENSLACP00000009351	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.524
JAG1	H3AML2_LATCH	ENSLACP00000001302	ENSLACP00000010883	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Uncharacterized protein.	0.713
JAG1	JAG2	ENSLACP00000001302	ENSLACP00000014617	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.958
JAG1	LOC102353790	ENSLACP00000001302	ENSLACP00000000182	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Uncharacterized protein.	0.984
JAG1	LOC102357987	ENSLACP00000001302	ENSLACP00000014598	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Uncharacterized protein.	0.996