(14 nodes) GroEL-like apical domain superfamily network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	MKKS	McKusick-Kaufman syndrome. (575 aa)
	HSPD1	Heat shock protein family D (Hsp60) member 1; Belongs to the chaperonin (HSP60) family. (565 aa)
	CCT6B	Chaperonin containing TCP1 subunit 6B. (536 aa)
	TCP1	T-complex 1. (559 aa)
	PIKFYVE	Phosphoinositide kinase, FYVE-type zinc finger containing. (2113 aa)
	CCT7	T-complex protein 1 subunit eta; Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin. (561 aa)
	CCT3	T-complex protein 1 subunit gamma. (548 aa)
	CCT8	Chaperonin containing TCP1 subunit 8. (557 aa)
	CCT4	T-complex protein 1 subunit delta. (535 aa)
	BBS12	Bardet-Biedl syndrome 12. (709 aa)
	BBS10	Bardet-Biedl syndrome 10. (714 aa)
	CCT5	Chaperonin containing TCP1 subunit 5. (554 aa)
	H3A6Y2_LATCH	Uncharacterized protein. (564 aa)
	CCT2	Chaperonin containing TCP1 subunit 2. (535 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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structured XML interaction data, according to the 'PSI-MI' data standard

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node degree of proteins in your network (given the current score cut-off)

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a flat-file format describing the coordinates and colors of nodes in the network

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BBS10	BBS12	ENSLACP00000001885	ENSLACP00000001386	Bardet-Biedl syndrome 10.	Bardet-Biedl syndrome 12.	0.875
BBS10	CCT2	ENSLACP00000001885	ENSLACP00000005828	Bardet-Biedl syndrome 10.	Chaperonin containing TCP1 subunit 2.	0.981
BBS10	CCT3	ENSLACP00000001885	ENSLACP00000010673	Bardet-Biedl syndrome 10.	T-complex protein 1 subunit gamma.	0.981
BBS10	CCT4	ENSLACP00000001885	ENSLACP00000020602	Bardet-Biedl syndrome 10.	T-complex protein 1 subunit delta.	0.921
BBS10	CCT5	ENSLACP00000001885	ENSLACP00000002511	Bardet-Biedl syndrome 10.	Chaperonin containing TCP1 subunit 5.	0.980
BBS10	CCT6B	ENSLACP00000001885	ENSLACP00000021504	Bardet-Biedl syndrome 10.	Chaperonin containing TCP1 subunit 6B.	0.987
BBS10	CCT7	ENSLACP00000001885	ENSLACP00000011702	Bardet-Biedl syndrome 10.	T-complex protein 1 subunit eta; Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.	0.980
BBS10	CCT8	ENSLACP00000001885	ENSLACP00000008299	Bardet-Biedl syndrome 10.	Chaperonin containing TCP1 subunit 8.	0.927
BBS10	H3A6Y2_LATCH	ENSLACP00000001885	ENSLACP00000005403	Bardet-Biedl syndrome 10.	Uncharacterized protein.	0.916
BBS10	HSPD1	ENSLACP00000001885	ENSLACP00000017367	Bardet-Biedl syndrome 10.	Heat shock protein family D (Hsp60) member 1; Belongs to the chaperonin (HSP60) family.	0.552
BBS10	MKKS	ENSLACP00000001885	ENSLACP00000006659	Bardet-Biedl syndrome 10.	McKusick-Kaufman syndrome.	0.697
BBS10	TCP1	ENSLACP00000001885	ENSLACP00000016811	Bardet-Biedl syndrome 10.	T-complex 1.	0.505
BBS12	BBS10	ENSLACP00000001386	ENSLACP00000001885	Bardet-Biedl syndrome 12.	Bardet-Biedl syndrome 10.	0.875
BBS12	CCT2	ENSLACP00000001386	ENSLACP00000005828	Bardet-Biedl syndrome 12.	Chaperonin containing TCP1 subunit 2.	0.581
BBS12	CCT3	ENSLACP00000001386	ENSLACP00000010673	Bardet-Biedl syndrome 12.	T-complex protein 1 subunit gamma.	0.581
BBS12	CCT4	ENSLACP00000001386	ENSLACP00000020602	Bardet-Biedl syndrome 12.	T-complex protein 1 subunit delta.	0.581
BBS12	CCT5	ENSLACP00000001386	ENSLACP00000002511	Bardet-Biedl syndrome 12.	Chaperonin containing TCP1 subunit 5.	0.581
BBS12	CCT8	ENSLACP00000001386	ENSLACP00000008299	Bardet-Biedl syndrome 12.	Chaperonin containing TCP1 subunit 8.	0.630
BBS12	H3A6Y2_LATCH	ENSLACP00000001386	ENSLACP00000005403	Bardet-Biedl syndrome 12.	Uncharacterized protein.	0.527
BBS12	MKKS	ENSLACP00000001386	ENSLACP00000006659	Bardet-Biedl syndrome 12.	McKusick-Kaufman syndrome.	0.811