(26 nodes) Frizzled cysteine-rich domain superfamily network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC102355199	Uncharacterized protein. (301 aa)
	LOC102356742	Sizzled. (295 aa)
	MFRP	Membrane frizzled-related protein. (588 aa)
	FZD6	Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family. (712 aa)
	FZD7	Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (555 aa)
	SFRP5	Secreted frizzled related protein 5. (309 aa)
	LOC102359071	Uncharacterized protein. (297 aa)
	FZD1	Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family. (557 aa)
	MUSK	Muscle associated receptor tyrosine kinase. (923 aa)
	FZD3	Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (604 aa)
	SFRP1-2	FZ domain-containing protein. (203 aa)
	ROR1	Receptor tyrosine kinase like orphan receptor 1. (769 aa)
	SFRP2	Secreted frizzled related protein 2. (294 aa)
	H3AA95_LATCH	FZ domain-containing protein. (361 aa)
	SFRP4	Secreted frizzled related protein 4. (198 aa)
	FRZB	Frizzled related protein. (318 aa)
	CPZ	Carboxypeptidase Z. (611 aa)
	SMO	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (820 aa)
	FZD4	Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (530 aa)
	ROR2	Receptor tyrosine kinase like orphan receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (882 aa)
	CORIN	Corin, serine peptidase. (753 aa)
	FZD8	Frizzled class receptor 8; Belongs to the G-protein coupled receptor Fz/Smo family. (582 aa)
	FZD9	Frizzled class receptor 9; Belongs to the G-protein coupled receptor Fz/Smo family. (583 aa)
	FZD10	Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family. (580 aa)
	FZD2	Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (552 aa)
	LOC102363206	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (575 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CPZ	MFRP	ENSLACP00000003580	ENSLACP00000018474	Carboxypeptidase Z.	Membrane frizzled-related protein.	0.418
FZD1	FZD3	ENSLACP00000014874	ENSLACP00000012917	Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family.	Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family.	0.436
FZD1	FZD4	ENSLACP00000014874	ENSLACP00000001995	Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family.	Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family.	0.457
FZD1	FZD6	ENSLACP00000014874	ENSLACP00000016182	Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family.	Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family.	0.509
FZD1	LOC102359071	ENSLACP00000014874	ENSLACP00000014878	Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family.	Uncharacterized protein.	0.650
FZD1	ROR1	ENSLACP00000014874	ENSLACP00000010024	Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family.	Receptor tyrosine kinase like orphan receptor 1.	0.943
FZD1	ROR2	ENSLACP00000014874	ENSLACP00000001497	Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family.	Receptor tyrosine kinase like orphan receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily.	0.516
FZD1	SFRP1-2	ENSLACP00000014874	ENSLACP00000011164	Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family.	FZ domain-containing protein.	0.665
FZD1	SFRP2	ENSLACP00000014874	ENSLACP00000007301	Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family.	Secreted frizzled related protein 2.	0.692
FZD1	SFRP5	ENSLACP00000014874	ENSLACP00000015584	Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family.	Secreted frizzled related protein 5.	0.665
FZD10	FZD3	ENSLACP00000021475	ENSLACP00000012917	Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family.	Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family.	0.481
FZD10	FZD6	ENSLACP00000021475	ENSLACP00000016182	Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family.	Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family.	0.504
FZD10	LOC102359071	ENSLACP00000021475	ENSLACP00000014878	Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family.	Uncharacterized protein.	0.650
FZD10	ROR1	ENSLACP00000021475	ENSLACP00000010024	Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family.	Receptor tyrosine kinase like orphan receptor 1.	0.933
FZD10	SFRP1-2	ENSLACP00000021475	ENSLACP00000011164	Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family.	FZ domain-containing protein.	0.664
FZD10	SFRP2	ENSLACP00000021475	ENSLACP00000007301	Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family.	Secreted frizzled related protein 2.	0.650
FZD10	SFRP5	ENSLACP00000021475	ENSLACP00000015584	Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family.	Secreted frizzled related protein 5.	0.664
FZD2	FZD3	ENSLACP00000020261	ENSLACP00000012917	Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family.	Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family.	0.435
FZD2	FZD4	ENSLACP00000020261	ENSLACP00000001995	Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family.	Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family.	0.452
FZD2	FZD6	ENSLACP00000020261	ENSLACP00000016182	Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family.	Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family.	0.509