(25 nodes) Translesion Synthesis by POLH network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SPRTN	SprT-like N-terminal domain. (529 aa)
	UFD1	Ubiquitin recognition factor in ER associated degradation 1. (302 aa)
	LOC102365663	Zgc:136908; Belongs to the AAA ATPase family. (697 aa)
	SPATA5	Spermatogenesis associated 5. (795 aa)
	ATAD5	ATPase family AAA domain containing 5. (1828 aa)
	RFC5	Replication factor C subunit 5. (333 aa)
	RFC4	Replication factor C subunit 4. (360 aa)
	SPATA5L1	Spermatogenesis associated 5 like 1. (792 aa)
	RFC2	Replication factor C subunit 2. (396 aa)
	MEIOB	Meiosis specific with OB-fold. (470 aa)
	RPA3	Replication protein A3. (121 aa)
	KXD1	Ubiquitin-like domain-containing protein. (231 aa)
	RPS27A	Ribosomal protein S27a. (156 aa)
	RPA1	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (495 aa)
	LOC102349640	Si:dkey-24l11.2. (660 aa)
	VCP	Valosin containing protein. (801 aa)
	POLH	DNA polymerase eta. (729 aa)
	RCBTB1	RCC1 and BTB domain containing protein 1. (531 aa)
	RFC3	Replication factor C subunit 3. (237 aa)
	RCHY1	Uncharacterized protein. (238 aa)
	RFC1	Replication factor C subunit 1. (1152 aa)
	LOC102346166	Ubiquitin-like domain-containing protein. (95 aa)
	LOC102350907	Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa)
	RCBTB2	RCC1 and BTB domain containing protein 2. (413 aa)
	PCNA	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATAD5	LOC102346166	ENSLACP00000019203	ENSLACP00000003410	ATPase family AAA domain containing 5.	Ubiquitin-like domain-containing protein.	0.554
ATAD5	LOC102365663	ENSLACP00000019203	ENSLACP00000018103	ATPase family AAA domain containing 5.	Zgc:136908; Belongs to the AAA ATPase family.	0.503
ATAD5	MEIOB	ENSLACP00000019203	ENSLACP00000023109	ATPase family AAA domain containing 5.	Meiosis specific with OB-fold.	0.692
ATAD5	PCNA	ENSLACP00000019203	ENSLACP00000006575	ATPase family AAA domain containing 5.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.981
ATAD5	POLH	ENSLACP00000019203	ENSLACP00000012984	ATPase family AAA domain containing 5.	DNA polymerase eta.	0.682
ATAD5	RFC1	ENSLACP00000019203	ENSLACP00000003355	ATPase family AAA domain containing 5.	Replication factor C subunit 1.	0.716
ATAD5	RFC2	ENSLACP00000019203	ENSLACP00000021161	ATPase family AAA domain containing 5.	Replication factor C subunit 2.	0.985
ATAD5	RFC3	ENSLACP00000019203	ENSLACP00000011255	ATPase family AAA domain containing 5.	Replication factor C subunit 3.	0.992
ATAD5	RFC4	ENSLACP00000019203	ENSLACP00000020302	ATPase family AAA domain containing 5.	Replication factor C subunit 4.	0.991
ATAD5	RFC5	ENSLACP00000019203	ENSLACP00000019284	ATPase family AAA domain containing 5.	Replication factor C subunit 5.	0.989
ATAD5	RPA1	ENSLACP00000019203	ENSLACP00000008142	ATPase family AAA domain containing 5.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.705
ATAD5	RPA3	ENSLACP00000019203	ENSLACP00000010252	ATPase family AAA domain containing 5.	Replication protein A3.	0.641
ATAD5	RPS27A	ENSLACP00000019203	ENSLACP00000008678	ATPase family AAA domain containing 5.	Ribosomal protein S27a.	0.554
ATAD5	SPATA5	ENSLACP00000019203	ENSLACP00000018750	ATPase family AAA domain containing 5.	Spermatogenesis associated 5.	0.503
ATAD5	SPATA5L1	ENSLACP00000019203	ENSLACP00000023061	ATPase family AAA domain containing 5.	Spermatogenesis associated 5 like 1.	0.503
ATAD5	SPRTN	ENSLACP00000019203	ENSLACP00000018686	ATPase family AAA domain containing 5.	SprT-like N-terminal domain.	0.730
ATAD5	UFD1	ENSLACP00000019203	ENSLACP00000017179	ATPase family AAA domain containing 5.	Ubiquitin recognition factor in ER associated degradation 1.	0.655
ATAD5	VCP	ENSLACP00000019203	ENSLACP00000013937	ATPase family AAA domain containing 5.	Valosin containing protein.	0.503
KXD1	LOC102346166	ENSLACP00000009213	ENSLACP00000003410	Ubiquitin-like domain-containing protein.	Ubiquitin-like domain-containing protein.	0.977
KXD1	LOC102365663	ENSLACP00000009213	ENSLACP00000018103	Ubiquitin-like domain-containing protein.	Zgc:136908; Belongs to the AAA ATPase family.	0.740