(24 nodes) Apoptotic factor-mediated response network (Latimeria chalumnae)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

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Known Interactions

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Predicted Interactions

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protein homology

Your Input:
	APAF1	Apoptotic peptidase activating factor 1. (1202 aa)
	H2ZUR2_LATCH	Septin-type G domain-containing protein; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (309 aa)
	LOC102345199	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (115 aa)
	H3A5S7_LATCH	Septin-type G domain-containing protein; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (287 aa)
	LOC102363280	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (104 aa)
	FILIP1L	Filamin A interacting protein 1 like. (1143 aa)
	BAX	Uncharacterized protein. (223 aa)
	CASP3	Caspase 3; Belongs to the peptidase C14A family. (290 aa)
	GSDME	Uncharacterized protein. (491 aa)
	AVEN	Apoptosis and caspase activation inhibitor. (348 aa)
	LOC102353741	Septin-type G domain-containing protein; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (266 aa)
	APIP	Methylthioribulose-1-phosphate dehydratase; Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway. May play a role in apoptosis. (254 aa)
	LOC102359041	Zgc:153993. (208 aa)
	LOC102367521	Uncharacterized protein; Belongs to the peptidase C14A family. (253 aa)
	H3B192_LATCH	Uncharacterized protein. (318 aa)
	SEPTIN5	Septin 5b; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (394 aa)
	TMEM198	Transmembrane protein 198. (365 aa)
	LOC102357497	DUF4203 domain-containing protein. (354 aa)
	BAK1	BCL2 antagonist/killer 1. (239 aa)
	XIAP	X-linked inhibitor of apoptosis. (606 aa)
	DIABLO	Diablo, IAP-binding mitochondrial protein b. (257 aa)
	CASP9	Caspase 9; Belongs to the peptidase C14A family. (457 aa)
	SEPTIN4	Septin-type G domain-containing protein; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (490 aa)
	CASP7	Caspase 7; Belongs to the peptidase C14A family. (313 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APAF1	APIP	ENSLACP00000014568	ENSLACP00000011333	Apoptotic peptidase activating factor 1.	Methylthioribulose-1-phosphate dehydratase; Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway. May play a role in apoptosis.	0.991
APAF1	AVEN	ENSLACP00000014568	ENSLACP00000010415	Apoptotic peptidase activating factor 1.	Apoptosis and caspase activation inhibitor.	0.989
APAF1	BAK1	ENSLACP00000014568	ENSLACP00000018296	Apoptotic peptidase activating factor 1.	BCL2 antagonist/killer 1.	0.670
APAF1	BAX	ENSLACP00000014568	ENSLACP00000007049	Apoptotic peptidase activating factor 1.	Uncharacterized protein.	0.800
APAF1	CASP3	ENSLACP00000014568	ENSLACP00000007386	Apoptotic peptidase activating factor 1.	Caspase 3; Belongs to the peptidase C14A family.	0.930
APAF1	CASP7	ENSLACP00000014568	ENSLACP00000022676	Apoptotic peptidase activating factor 1.	Caspase 7; Belongs to the peptidase C14A family.	0.877
APAF1	CASP9	ENSLACP00000014568	ENSLACP00000020786	Apoptotic peptidase activating factor 1.	Caspase 9; Belongs to the peptidase C14A family.	0.995
APAF1	DIABLO	ENSLACP00000014568	ENSLACP00000020692	Apoptotic peptidase activating factor 1.	Diablo, IAP-binding mitochondrial protein b.	0.990
APAF1	H3B192_LATCH	ENSLACP00000014568	ENSLACP00000015663	Apoptotic peptidase activating factor 1.	Uncharacterized protein.	0.790
APAF1	LOC102345199	ENSLACP00000014568	ENSLACP00000001282	Apoptotic peptidase activating factor 1.	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.999
APAF1	LOC102357497	ENSLACP00000014568	ENSLACP00000017947	Apoptotic peptidase activating factor 1.	DUF4203 domain-containing protein.	0.790
APAF1	LOC102359041	ENSLACP00000014568	ENSLACP00000012675	Apoptotic peptidase activating factor 1.	Zgc:153993.	0.670
APAF1	LOC102363280	ENSLACP00000014568	ENSLACP00000005807	Apoptotic peptidase activating factor 1.	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.999
APAF1	LOC102367521	ENSLACP00000014568	ENSLACP00000014331	Apoptotic peptidase activating factor 1.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.864
APAF1	TMEM198	ENSLACP00000014568	ENSLACP00000017893	Apoptotic peptidase activating factor 1.	Transmembrane protein 198.	0.790
APAF1	XIAP	ENSLACP00000014568	ENSLACP00000018655	Apoptotic peptidase activating factor 1.	X-linked inhibitor of apoptosis.	0.916
APIP	APAF1	ENSLACP00000011333	ENSLACP00000014568	Methylthioribulose-1-phosphate dehydratase; Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway. May play a role in apoptosis.	Apoptotic peptidase activating factor 1.	0.991
APIP	AVEN	ENSLACP00000011333	ENSLACP00000010415	Methylthioribulose-1-phosphate dehydratase; Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway. May play a role in apoptosis.	Apoptosis and caspase activation inhibitor.	0.422
APIP	CASP9	ENSLACP00000011333	ENSLACP00000020786	Methylthioribulose-1-phosphate dehydratase; Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway. May play a role in apoptosis.	Caspase 9; Belongs to the peptidase C14A family.	0.767
APIP	LOC102345199	ENSLACP00000011333	ENSLACP00000001282	Methylthioribulose-1-phosphate dehydratase; Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway. May play a role in apoptosis.	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.549