(10 nodes) Neurotransmitter clearance network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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Others

textmining

co-expression

protein homology

Your Input:
	SLC6A4	Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (660 aa)
	LOC102360602	Si:ch211-71n6.4. (572 aa)
	LOC102359345	Transmembrane O-methyltransferase. (268 aa)
	LOC102357698	Uncharacterized protein. (267 aa)
	LOC102367330	Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (616 aa)
	COMTD1	Catechol-O-methyltransferase domain containing 1. (265 aa)
	SLC6A3	Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (624 aa)
	LOC102363644	Catechol O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. (262 aa)
	LOC102350038	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (597 aa)
	COMT	Catechol O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. (219 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
COMT	SLC6A3	ENSLACP00000019019	ENSLACP00000002580	Catechol O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones.	Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.	0.428
LOC102363644	SLC6A3	ENSLACP00000001738	ENSLACP00000002580	Catechol O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones.	Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.	0.428
SLC6A3	COMT	ENSLACP00000002580	ENSLACP00000019019	Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.	Catechol O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones.	0.428
SLC6A3	LOC102363644	ENSLACP00000002580	ENSLACP00000001738	Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.	Catechol O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones.	0.428