(82 nodes) Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal network (Latimeria chalumnae)

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

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Your Input:
	BUB3	BUB3 mitotic checkpoint protein. (361 aa)
	SKA1	Spindle and kinetochore associated complex subunit 1. (255 aa)
	NUP37	Nucleoporin 37. (326 aa)
	CENPM	Uncharacterized protein. (175 aa)
	ERCC6L	ERCC excision repair 6 like, spindle assembly checkpoint helicase. (1224 aa)
	DYNC1I1	Uncharacterized protein. (99 aa)
	NUP98	Nucleoporin 98. (1790 aa)
	H3A0V9_LATCH	DUF5595 domain-containing protein. (661 aa)
	SPC25	SPC25 component of NDC80 kinetochore complex. (232 aa)
	PLK1	Serine/threonine-protein kinase PLK. (595 aa)
	NUP85	Nuclear pore complex protein Nup85; Functions as a component of the nuclear pore complex (NPC). (656 aa)
	LOC102345465	Uncharacterized protein. (347 aa)
	CLASP2	Cytoplasmic linker associated protein 2. (1303 aa)
	H3A8L7_LATCH	Uncharacterized protein. (117 aa)
	CDC20	Cell division cycle 20. (502 aa)
	ZWILCH	Zwilch kinetochore protein. (512 aa)
	NDE1	NudE neurodevelopment protein 1. (345 aa)
	DYNC1LI2	Dynein light intermediate chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. (505 aa)
	KIF2C	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (501 aa)
	SEH1L	SEH1 like nucleoporin; Belongs to the WD repeat SEC13 family. (468 aa)
	MAD2L1	Mitotic arrest deficient 2 like 1. (202 aa)
	MAPRE1	Microtubule associated protein RP/EB family member 1. (262 aa)
	PPP2R5B	Serine/threonine protein phosphatase 2A regulatory subunit; Belongs to the phosphatase 2A regulatory subunit. (495 aa)
	CENPU	Centromere protein U. (311 aa)
	H3AH17_LATCH	Shugoshin_C domain-containing protein. (672 aa)
	DYNC1I2	Dynein cytoplasmic 1 intermediate chain 2. (636 aa)
	H3AJQ7_LATCH	Uncharacterized protein. (46 aa)
	NDEL1	NudE neurodevelopment protein 1 like 1. (343 aa)
	NUP43	Nucleoporin 43. (374 aa)
	LOC102350821	Serine/threonine-protein phosphatase. (309 aa)
	H3AN32_LATCH	Uncharacterized protein. (3251 aa)
	NUP107	Nuclear pore complex protein; Functions as a component of the nuclear pore complex (NPC). (930 aa)
	H3ASX0_LATCH	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (397 aa)
	LOC102346472	Uncharacterized protein. (168 aa)
	NUDC	Nuclear distribution C, dynein complex regulator. (337 aa)
	CENPL	Centromere protein L. (330 aa)
	PPP2R1A	Protein phosphatase 2 scaffold subunit Aalpha. (591 aa)
	RANGAP1	Ran GTPase activating protein 1. (615 aa)
	CENPK	Centromere protein K. (291 aa)
	DYNC1H1	Dynein cytoplasmic 1 heavy chain 1. (4615 aa)
	NUP133	Nucleoporin 133; Belongs to the actin family. (1421 aa)
	MEIOC	Meiosis specific with coiled-coil domain. (938 aa)
	SEC13	SEC13 homolog, nuclear pore and COPII coat complex component; Belongs to the WD repeat SEC13 family. (320 aa)
	PMF1	Polyamine modulated factor 1. (223 aa)
	CENPC	CENP-C_C domain-containing protein. (824 aa)
	RCC2	Regulator of chromosome condensation 2. (498 aa)
	PPP2CA	Serine/threonine-protein phosphatase. (309 aa)
	CENPI	Centromere protein I. (701 aa)
	AHCTF1	AT-hook containing transcription factor 1. (2245 aa)
	INCENP	INCENP_ARK-bind domain-containing protein. (887 aa)
	SPDL1	Protein Spindly; Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex; Belongs to the Spindly family. (614 aa)
	PPP2R5E	Serine/threonine protein phosphatase 2A regulatory subunit; Belongs to the phosphatase 2A regulatory subunit. (467 aa)
	BIRC5	Baculoviral IAP repeat containing 5. (139 aa)
	H3BEF8_LATCH	Cytoplasmic linker associated protein 1a. (1413 aa)
	KNTC1	Kinetochore associated 1. (2225 aa)
	CLIP1	CAP-Gly domain containing linker protein 1. (1445 aa)
	B9D2	B9 domain containing 2. (175 aa)
	PAFAH1B1	Lissencephaly-1 homolog; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. May be required for proliferation of neuronal precursors and neuronal migration; Belongs to the WD repeat LIS1/nudF family. (410 aa)
	MIS12	MIS12 kinetochore complex component. (215 aa)
	XPO1	Exportin 1. (1078 aa)
	DYNLL1	Dynein light chain. (115 aa)
	CLIP2	CAP-Gly domain containing linker protein 2. (1042 aa)
	ZW10	Zw10 kinetochore protein. (708 aa)
	PPP2R1B	Protein phosphatase 2 scaffold subunit Abeta. (589 aa)
	H3BHP0_LATCH	Uncharacterized protein. (410 aa)
	CKAP5	Cytoskeleton associated protein 5. (1557 aa)
	NUP160	Nucleoporin 160. (1326 aa)
	BUB1	BUB1 mitotic checkpoint serine/threonine kinase. (1272 aa)
	CENPQ	Uncharacterized protein. (155 aa)
	DYNC1LI1	Dynein light intermediate chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. (502 aa)
	CLASP1	Uncharacterized protein. (66 aa)
	CENPF	Centromere protein F. (3070 aa)
	MAD1L1	Mitotic arrest deficient 1 like 1. (684 aa)
	KIF18A	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (962 aa)
	CDCA8	Nbl1_Borealin_N domain-containing protein. (289 aa)
	PPP2R5D	Serine/threonine protein phosphatase 2A regulatory subunit; Belongs to the phosphatase 2A regulatory subunit. (619 aa)
	CENPN	Centromere protein N. (348 aa)
	PPP2R5C	Serine/threonine protein phosphatase 2A regulatory subunit; Belongs to the phosphatase 2A regulatory subunit. (610 aa)
	SKA2	Spindle and kinetochore associated complex subunit 2. (249 aa)
	CENPO	Centromere protein O. (254 aa)
	ITGB3BP	Uncharacterized protein. (159 aa)
	CDC20B	Cell division cycle 20B. (285 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AHCTF1	BUB1	ENSLACP00000019737	ENSLACP00000021843	AT-hook containing transcription factor 1.	BUB1 mitotic checkpoint serine/threonine kinase.	0.634
AHCTF1	BUB3	ENSLACP00000019737	ENSLACP00000001107	AT-hook containing transcription factor 1.	BUB3 mitotic checkpoint protein.	0.663
AHCTF1	CDC20	ENSLACP00000019737	ENSLACP00000006012	AT-hook containing transcription factor 1.	Cell division cycle 20.	0.645
AHCTF1	CDC20B	ENSLACP00000019737	ENSLACP00000023460	AT-hook containing transcription factor 1.	Cell division cycle 20B.	0.645
AHCTF1	H3AN32_LATCH	ENSLACP00000019737	ENSLACP00000011053	AT-hook containing transcription factor 1.	Uncharacterized protein.	0.862
AHCTF1	LOC102345465	ENSLACP00000019737	ENSLACP00000004846	AT-hook containing transcription factor 1.	Uncharacterized protein.	0.862
AHCTF1	NUP107	ENSLACP00000019737	ENSLACP00000011980	AT-hook containing transcription factor 1.	Nuclear pore complex protein; Functions as a component of the nuclear pore complex (NPC).	0.989
AHCTF1	NUP133	ENSLACP00000019737	ENSLACP00000015757	AT-hook containing transcription factor 1.	Nucleoporin 133; Belongs to the actin family.	0.989
AHCTF1	NUP160	ENSLACP00000019737	ENSLACP00000021641	AT-hook containing transcription factor 1.	Nucleoporin 160.	0.989
AHCTF1	NUP37	ENSLACP00000019737	ENSLACP00000001626	AT-hook containing transcription factor 1.	Nucleoporin 37.	0.988
AHCTF1	NUP43	ENSLACP00000019737	ENSLACP00000010796	AT-hook containing transcription factor 1.	Nucleoporin 43.	0.987
AHCTF1	NUP85	ENSLACP00000019737	ENSLACP00000004845	AT-hook containing transcription factor 1.	Nuclear pore complex protein Nup85; Functions as a component of the nuclear pore complex (NPC).	0.982
AHCTF1	NUP98	ENSLACP00000019737	ENSLACP00000003011	AT-hook containing transcription factor 1.	Nucleoporin 98.	0.988
AHCTF1	PLK1	ENSLACP00000019737	ENSLACP00000004640	AT-hook containing transcription factor 1.	Serine/threonine-protein kinase PLK.	0.856
AHCTF1	RANGAP1	ENSLACP00000019737	ENSLACP00000015278	AT-hook containing transcription factor 1.	Ran GTPase activating protein 1.	0.424
AHCTF1	SEC13	ENSLACP00000019737	ENSLACP00000015793	AT-hook containing transcription factor 1.	SEC13 homolog, nuclear pore and COPII coat complex component; Belongs to the WD repeat SEC13 family.	0.986
AHCTF1	SEH1L	ENSLACP00000019737	ENSLACP00000008357	AT-hook containing transcription factor 1.	SEH1 like nucleoporin; Belongs to the WD repeat SEC13 family.	0.985
BIRC5	BUB1	ENSLACP00000020074	ENSLACP00000021843	Baculoviral IAP repeat containing 5.	BUB1 mitotic checkpoint serine/threonine kinase.	0.896
BIRC5	BUB3	ENSLACP00000020074	ENSLACP00000001107	Baculoviral IAP repeat containing 5.	BUB3 mitotic checkpoint protein.	0.438
BIRC5	CDC20	ENSLACP00000020074	ENSLACP00000006012	Baculoviral IAP repeat containing 5.	Cell division cycle 20.	0.863