(13 nodes) Methylation network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC102352197	Methyltranfer_dom domain-containing protein. (272 aa)
	MAT2A	S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. (391 aa)
	LOC102361022	S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. (391 aa)
	AHCY	Adenosylhomocysteinase; Belongs to the adenosylhomocysteinase family. (507 aa)
	TRMT112	tRNA methyltransferase subunit 11-2. (123 aa)
	COMT	Catechol O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. (219 aa)
	MTR	Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1252 aa)
	MAT2B	Methionine adenosyltransferase 2 subunit beta; Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine. (341 aa)
	MTRR	5-methyltetrahydrofolate-homocysteine methyltransferase reductase. (720 aa)
	N6AMT1	N-6 adenine-specific DNA methyltransferase 1. (216 aa)
	LOC102363644	Catechol O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. (262 aa)
	AS3MT	Methyltranfer_dom domain-containing protein. (407 aa)
	TPMT	Thiopurine S-methyltransferase. (219 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AHCY	LOC102361022	ENSLACP00000021693	ENSLACP00000004110	Adenosylhomocysteinase; Belongs to the adenosylhomocysteinase family.	S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP.	0.672
AHCY	MAT2A	ENSLACP00000021693	ENSLACP00000005914	Adenosylhomocysteinase; Belongs to the adenosylhomocysteinase family.	S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP.	0.672
AHCY	MTR	ENSLACP00000021693	ENSLACP00000018670	Adenosylhomocysteinase; Belongs to the adenosylhomocysteinase family.	Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.	0.982
AS3MT	TRMT112	ENSLACP00000006737	ENSLACP00000020367	Methyltranfer_dom domain-containing protein.	tRNA methyltransferase subunit 11-2.	0.583
COMT	LOC102361022	ENSLACP00000019019	ENSLACP00000004110	Catechol O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones.	S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP.	0.490
COMT	MAT2A	ENSLACP00000019019	ENSLACP00000005914	Catechol O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones.	S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP.	0.490
LOC102352197	TRMT112	ENSLACP00000005347	ENSLACP00000020367	Methyltranfer_dom domain-containing protein.	tRNA methyltransferase subunit 11-2.	0.583
LOC102361022	AHCY	ENSLACP00000004110	ENSLACP00000021693	S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP.	Adenosylhomocysteinase; Belongs to the adenosylhomocysteinase family.	0.672
LOC102361022	COMT	ENSLACP00000004110	ENSLACP00000019019	S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP.	Catechol O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones.	0.490
LOC102361022	LOC102363644	ENSLACP00000004110	ENSLACP00000001738	S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP.	Catechol O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones.	0.490
LOC102361022	MAT2A	ENSLACP00000004110	ENSLACP00000005914	S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP.	S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP.	0.900
LOC102361022	MAT2B	ENSLACP00000004110	ENSLACP00000011565	S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP.	Methionine adenosyltransferase 2 subunit beta; Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine.	0.993
LOC102361022	MTR	ENSLACP00000004110	ENSLACP00000018670	S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP.	Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.	0.963
LOC102361022	N6AMT1	ENSLACP00000004110	ENSLACP00000006808	S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP.	N-6 adenine-specific DNA methyltransferase 1.	0.571
LOC102363644	LOC102361022	ENSLACP00000001738	ENSLACP00000004110	Catechol O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones.	S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP.	0.490
LOC102363644	MAT2A	ENSLACP00000001738	ENSLACP00000005914	Catechol O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones.	S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP.	0.490
MAT2A	AHCY	ENSLACP00000005914	ENSLACP00000021693	S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP.	Adenosylhomocysteinase; Belongs to the adenosylhomocysteinase family.	0.672
MAT2A	COMT	ENSLACP00000005914	ENSLACP00000019019	S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP.	Catechol O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones.	0.490
MAT2A	LOC102361022	ENSLACP00000005914	ENSLACP00000004110	S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP.	S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP.	0.900
MAT2A	LOC102363644	ENSLACP00000005914	ENSLACP00000001738	S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP.	Catechol O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones.	0.490