STRINGSTRING
NHP2 NHP2 RFC5 RFC5 POLD1 POLD1 TRUB1 TRUB1 SHQ1 SHQ1 DKC1 DKC1 ANKRD44 ANKRD44 H3B155_LATCH H3B155_LATCH DNA2 DNA2 POLD2 POLD2 TERF2IP TERF2IP ANKRD66 ANKRD66 ANKRD28 ANKRD28 STN1 STN1 DSCC1 DSCC1 POLD4 POLD4 RFC3 RFC3 POLD3 POLD3 H3AL79_LATCH H3AL79_LATCH H3AKZ0_LATCH H3AKZ0_LATCH DAXX DAXX CCNA2 CCNA2 H2ZVL4_LATCH H2ZVL4_LATCH FEN1 FEN1 H2ZWI5_LATCH H2ZWI5_LATCH H2ZYB4_LATCH H2ZYB4_LATCH CHTF8 CHTF8 H2ZZP4_LATCH H2ZZP4_LATCH NOP10 NOP10 RFC1 RFC1 GAR1 GAR1 H4C11 H4C11 H3A5V3_LATCH H3A5V3_LATCH PCNA PCNA TERF1 TERF1 POT1 POT1 BLM BLM H3ADV1_LATCH H3ADV1_LATCH RPA1 RPA1 CCNA1 CCNA1 LOC102367189 LOC102367189 LOC102367082 LOC102367082 H3AJV2_LATCH H3AJV2_LATCH H3AK44_LATCH H3AK44_LATCH RPA3 RPA3 PPP6R2 PPP6R2 CHTF18 CHTF18 H3ALV1_LATCH H3ALV1_LATCH LOC102351398 LOC102351398 H2ZS39_LATCH H2ZS39_LATCH PIF1 PIF1 H3AR57_LATCH H3AR57_LATCH H3A2S8_LATCH H3A2S8_LATCH H3A427_LATCH H3A427_LATCH LOC102361505 LOC102361505 RCBTB2 RCBTB2 H3A5E7_LATCH H3A5E7_LATCH RCBTB1 RCBTB1 H2BE1 H2BE1 ATRX ATRX MEIOB MEIOB PRIM2 PRIM2 ANKRD52 ANKRD52 CDK2 CDK2 PRIM1 PRIM1 PPP6R3 PPP6R3 EXD2 EXD2 RFC2 RFC2 PPP6C PPP6C RUVBL2 RUVBL2 RFC4 RFC4 TEN1 TEN1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NHP2Ribonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family. (155 aa)
RFC5Replication factor C subunit 5. (333 aa)
POLD1DNA polymerase. (1103 aa)
TRUB1TruB pseudouridine synthase family member 1. (298 aa)
SHQ1SHQ1, H/ACA ribonucleoprotein assembly factor. (663 aa)
DKC1Dyskerin pseudouridine synthase 1. (506 aa)
ANKRD44ANK_REP_REGION domain-containing protein. (619 aa)
H3B155_LATCHANK_REP_REGION domain-containing protein. (374 aa)
DNA2DNA replication helicase/nuclease 2. (925 aa)
POLD2DNA polymerase delta 2, accessory subunit. (469 aa)
TERF2IPTERF2 interacting protein. (455 aa)
ANKRD66Ankyrin repeat domain 66. (191 aa)
ANKRD28Ankyrin repeat domain 28. (934 aa)
STN1CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. (372 aa)
DSCC1DNA replication and sister chromatid cohesion 1. (390 aa)
POLD4Uncharacterized protein. (122 aa)
RFC3Replication factor C subunit 3. (237 aa)
POLD3Uncharacterized protein. (373 aa)
H3AL79_LATCHDNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (598 aa)
H3AKZ0_LATCHPolymerase (DNA directed), alpha 1. (630 aa)
DAXXDeath-domain associated protein. (728 aa)
CCNA2Cyclin A2; Belongs to the cyclin family. (447 aa)
H2ZVL4_LATCHHistone domain-containing protein; Belongs to the histone H2B family. (90 aa)
FEN1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (317 aa)
H2ZWI5_LATCHUncharacterized protein. (1469 aa)
H2ZYB4_LATCHUncharacterized protein. (423 aa)
CHTF8Chromosome transmission fidelity factor 8. (125 aa)
H2ZZP4_LATCHHistone H2B; Belongs to the histone H2B family. (138 aa)
NOP10NOP10 ribonucleoprotein. (64 aa)
RFC1Replication factor C subunit 1. (1152 aa)
GAR1H/ACA ribonucleoprotein complex subunit; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs. (166 aa)
H4C11Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
H3A5V3_LATCHRecQ helicase-like 4. (1456 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa)
TERF1Telomeric repeat binding factor 1. (344 aa)
POT1Protection of telomeres 1. (791 aa)
BLMBLM RecQ like helicase. (1450 aa)
H3ADV1_LATCHTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. (974 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (495 aa)
CCNA1Cyclin A1; Belongs to the cyclin family. (433 aa)
LOC102367189Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (342 aa)
LOC102367082XPGI domain-containing protein. (317 aa)
H3AJV2_LATCHPHD-type domain-containing protein. (679 aa)
H3AK44_LATCHHistone domain-containing protein; Belongs to the histone H2B family. (105 aa)
RPA3Replication protein A3. (121 aa)
PPP6R2Protein phosphatase 6 regulatory subunit 2. (865 aa)
CHTF18Chromosome transmission fidelity factor 18. (522 aa)
H3ALV1_LATCHUncharacterized protein. (375 aa)
LOC102351398Uncharacterized protein. (117 aa)
H2ZS39_LATCHHistone H2B; Belongs to the histone H2B family. (135 aa)
PIF1ATP-dependent DNA helicase; Belongs to the helicase family. (630 aa)
H3AR57_LATCHDNA_pol_B domain-containing protein. (238 aa)
H3A2S8_LATCHHistone H2B; Belongs to the histone H2B family. (138 aa)
H3A427_LATCHHistone H2B; Belongs to the histone H2B family. (137 aa)
LOC102361505Histone H2B; Belongs to the histone H2B family. (126 aa)
RCBTB2RCC1 and BTB domain containing protein 2. (413 aa)
H3A5E7_LATCHHistone H2B; Belongs to the histone H2B family. (130 aa)
RCBTB1RCC1 and BTB domain containing protein 1. (531 aa)
H2BE1Histone H2B; Belongs to the histone H2B family. (122 aa)
ATRXATRX chromatin remodeler. (2488 aa)
MEIOBMeiosis specific with OB-fold. (470 aa)
PRIM2DNA primase subunit 2. (321 aa)
ANKRD52Ankyrin repeat domain 52. (1049 aa)
CDK2Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (298 aa)
PRIM1DNA primase; Belongs to the eukaryotic-type primase small subunit family. (420 aa)
PPP6R3Protein phosphatase 6 regulatory subunit 3. (912 aa)
EXD2Exonuclease 3'-5' domain containing 2. (617 aa)
RFC2Replication factor C subunit 2. (396 aa)
PPP6CSerine/threonine-protein phosphatase. (305 aa)
RUVBL2RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (466 aa)
RFC4Replication factor C subunit 4. (360 aa)
TEN1TEN1 subunit of CST complex. (123 aa)
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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