(53 nodes) Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	AIM2	HIN-200 domain-containing protein. (205 aa)
	LOC102348796	Uncharacterized protein. (497 aa)
	M3XI97_LATCH	Thioredoxin domain-containing protein. (93 aa)
	M3XJL3_LATCH	HIN-200 domain-containing protein. (217 aa)
	BCL2L2	BCL2 like 2. (189 aa)
	LOC102365523	Uncharacterized protein; Belongs to the peptidase C19 family. (930 aa)
	H3A7T5_LATCH	Uncharacterized protein. (999 aa)
	PANX1	Pannexin; Structural component of the gap junctions and the hemichannels. (428 aa)
	SUGT1	SGT1 homolog, MIS12 kinetochore complex assembly cochaperone. (336 aa)
	H3A6G9_LATCH	Uncharacterized protein. (840 aa)
	IKBKG	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (435 aa)
	RIPK2	Receptor interacting serine/threonine kinase 2. (567 aa)
	ARRDC2	Arrestin domain containing 2. (407 aa)
	PSTPIP2	Proline-serine-threonine phosphatase interacting protein 2. (267 aa)
	MAP3K20	Uncharacterized protein. (792 aa)
	LOC102350907	Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa)
	LOC102348725	Uncharacterized protein. (641 aa)
	LOC102354290	Uncharacterized protein. (579 aa)
	ARRDC3	Arrestin domain containing 3. (414 aa)
	LOC102358578	Transmembrane protein 189. (285 aa)
	CASP2	Caspase 2; Belongs to the peptidase C14A family. (433 aa)
	H3A007_LATCH	Uncharacterized protein. (52 aa)
	LOC102347712	Thioredoxin; Belongs to the thioredoxin family. (105 aa)
	H2ZX20_LATCH	Uncharacterized protein. (1016 aa)
	MAPK14	Mitogen-activated protein kinase. (399 aa)
	MAPK13	Mitogen-activated protein kinase. (162 aa)
	BIRC2	Baculoviral IAP repeat containing 2. (616 aa)
	TAB1	TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (436 aa)
	H2ZSP9_LATCH	Uncharacterized protein. (997 aa)
	MAP3K7	Mitogen-activated protein kinase kinase kinase 7. (580 aa)
	LOC102349920	Uncharacterized protein. (199 aa)
	NOD2	Nucleotide binding oligomerization domain containing 2. (854 aa)
	ARRDC4	Arrestin domain containing 4. (397 aa)
	NAIP	NLR family apoptosis inhibitory protein. (1422 aa)
	TXNIP	Thioredoxin interacting protein. (402 aa)
	KXD1	Ubiquitin-like domain-containing protein. (231 aa)
	NLRC4	NLR family CARD domain containing 4. (1032 aa)
	UBE2V2-2	Ubiquitin-conjugating enzyme E2 variant 2. (102 aa)
	H3B1U1_LATCH	RING-type domain-containing protein. (527 aa)
	PSTPIP1	Proline-serine-threonine phosphatase interacting protein 1. (299 aa)
	H3B3L3_LATCH	NACHT domain-containing protein. (837 aa)
	ARRDC1	Arrestin domain containing 1. (427 aa)
	LOC102354153	Si:ch211-212o1.2. (293 aa)
	NOD1	Nucleotide binding oligomerization domain containing 1. (830 aa)
	MAPK11	Mitogen-activated protein kinase. (361 aa)
	H3B7N1_LATCH	Zgc:171775. (210 aa)
	H3B8L2_LATCH	Protein kinase domain-containing protein. (82 aa)
	MAPK12	Uncharacterized protein. (103 aa)
	TAB3	TGF-beta activated kinase 1 (MAP3K7) binding protein 3. (672 aa)
	TAB2	TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (691 aa)
	RPS27A	Ribosomal protein S27a. (156 aa)
	UBE2V1	UBIQUITIN_CONJUGAT_2 domain-containing protein. (153 aa)
	BCL2L1	BCL2 like 1. (239 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AIM2	LOC102349920	ENSLACP00000021844	ENSLACP00000010067	HIN-200 domain-containing protein.	Uncharacterized protein.	0.948
AIM2	NAIP	ENSLACP00000021844	ENSLACP00000014136	HIN-200 domain-containing protein.	NLR family apoptosis inhibitory protein.	0.466
AIM2	NLRC4	ENSLACP00000021844	ENSLACP00000014259	HIN-200 domain-containing protein.	NLR family CARD domain containing 4.	0.910
AIM2	NOD2	ENSLACP00000021844	ENSLACP00000011767	HIN-200 domain-containing protein.	Nucleotide binding oligomerization domain containing 2.	0.412
ARRDC1	LOC102347712	ENSLACP00000016713	ENSLACP00000002294	Arrestin domain containing 1.	Thioredoxin; Belongs to the thioredoxin family.	0.778
ARRDC1	LOC102354290	ENSLACP00000016713	ENSLACP00000003364	Arrestin domain containing 1.	Uncharacterized protein.	0.650
ARRDC1	M3XI97_LATCH	ENSLACP00000016713	ENSLACP00000022453	Arrestin domain containing 1.	Thioredoxin domain-containing protein.	0.688
ARRDC2	LOC102347712	ENSLACP00000004094	ENSLACP00000002294	Arrestin domain containing 2.	Thioredoxin; Belongs to the thioredoxin family.	0.778
ARRDC2	LOC102354290	ENSLACP00000004094	ENSLACP00000003364	Arrestin domain containing 2.	Uncharacterized protein.	0.650
ARRDC2	M3XI97_LATCH	ENSLACP00000004094	ENSLACP00000022453	Arrestin domain containing 2.	Thioredoxin domain-containing protein.	0.688
ARRDC3	LOC102347712	ENSLACP00000003233	ENSLACP00000002294	Arrestin domain containing 3.	Thioredoxin; Belongs to the thioredoxin family.	0.778
ARRDC3	LOC102354290	ENSLACP00000003233	ENSLACP00000003364	Arrestin domain containing 3.	Uncharacterized protein.	0.650
ARRDC3	M3XI97_LATCH	ENSLACP00000003233	ENSLACP00000022453	Arrestin domain containing 3.	Thioredoxin domain-containing protein.	0.688
ARRDC4	LOC102347712	ENSLACP00000012943	ENSLACP00000002294	Arrestin domain containing 4.	Thioredoxin; Belongs to the thioredoxin family.	0.778
ARRDC4	LOC102354290	ENSLACP00000012943	ENSLACP00000003364	Arrestin domain containing 4.	Uncharacterized protein.	0.650
ARRDC4	M3XI97_LATCH	ENSLACP00000012943	ENSLACP00000022453	Arrestin domain containing 4.	Thioredoxin domain-containing protein.	0.688
BCL2L1	BCL2L2	ENSLACP00000011299	ENSLACP00000006748	BCL2 like 1.	BCL2 like 2.	0.498
BCL2L1	CASP2	ENSLACP00000011299	ENSLACP00000002990	BCL2 like 1.	Caspase 2; Belongs to the peptidase C14A family.	0.549
BCL2L1	H3A007_LATCH	ENSLACP00000011299	ENSLACP00000002978	BCL2 like 1.	Uncharacterized protein.	0.457
BCL2L1	TAB1	ENSLACP00000011299	ENSLACP00000000540	BCL2 like 1.	TGF-beta activated kinase 1 (MAP3K7) binding protein 1.	0.630