(93 nodes) p75 NTR receptor-mediated signalling network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	H2ZSQ8_LATCH	Uncharacterized protein. (197 aa)
	H2ZUX7_LATCH	DH domain-containing protein. (365 aa)
	ARHGEF33	DH domain-containing protein. (800 aa)
	NGFR	Nerve growth factor receptor. (197 aa)
	VAV3	Si:ch73-383g2.1. (488 aa)
	ARHGEF7-2	SH3 domain-containing protein. (141 aa)
	ARHGEF11	Rho guanine nucleotide exchange factor 11. (1546 aa)
	CASP2	Caspase 2; Belongs to the peptidase C14A family. (433 aa)
	LOC102346166	Ubiquitin-like domain-containing protein. (95 aa)
	ARHGEF10	Rho guanine nucleotide exchange factor 10. (1338 aa)
	TRAF6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (559 aa)
	ARHGEF39	Rho guanine nucleotide exchange factor (GEF) 39. (460 aa)
	LOC102350907	Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa)
	MCF2L	MCF.2 cell line derived transforming sequence like. (1140 aa)
	SOS1	SOS Ras/Rac guanine nucleotide exchange factor 1. (1331 aa)
	RIPK2	Receptor interacting serine/threonine kinase 2. (567 aa)
	LOC102351129	Rho guanine nucleotide exchange factor (GEF) 3, like. (503 aa)
	MAG	Myelin associated glycoprotein. (633 aa)
	NGEF	Neuronal guanine nucleotide exchange factor. (805 aa)
	CASP3	Caspase 3; Belongs to the peptidase C14A family. (290 aa)
	ARHGEF7	Rho guanine nucleotide exchange factor 7. (609 aa)
	ARHGEF3	Rho guanine nucleotide exchange factor 3. (525 aa)
	ARHGEF2	Rho/Rac guanine nucleotide exchange factor 2. (1027 aa)
	ARHGEF1	Rho guanine nucleotide exchange factor 1. (717 aa)
	LOC102366049	Rho/rac guanine nucleotide exchange factor (GEF) 18b. (1052 aa)
	PRDM4	PR/SET domain 4. (795 aa)
	SOS2	SOS Ras/Rho guanine nucleotide exchange factor 2. (1241 aa)
	RPS27A	Ribosomal protein S27a. (156 aa)
	H3AGK8_LATCH	Uncharacterized protein. (1244 aa)
	KXD1	Ubiquitin-like domain-containing protein. (231 aa)
	NET1	Neuroepithelial cell transforming 1. (631 aa)
	H3AJ45_LATCH	Uncharacterized protein. (651 aa)
	H3AJI4_LATCH	Uncharacterized protein. (272 aa)
	H3AJJ8_LATCH	Rho guanine nucleotide exchange factor (GEF) 15. (519 aa)
	LINGO1	Leucine rich repeat and Ig domain containing 1. (617 aa)
	PSENEN	Presenilin enhancer, gamma-secretase subunit. (101 aa)
	H3AL82_LATCH	Uncharacterized protein. (245 aa)
	ARHGEF12	Rho guanine nucleotide exchange factor 12. (1565 aa)
	ADAM17	ADAM metallopeptidase domain 17. (827 aa)
	H3AMR9_LATCH	Uncharacterized protein. (285 aa)
	ARHGEF37	Rho guanine nucleotide exchange factor 37. (690 aa)
	NCSTN	Nicastrin. (680 aa)
	H3AMY7_LATCH	Uncharacterized protein. (339 aa)
	BAD	Uncharacterized protein. (175 aa)
	ITSN1	Intersectin 1 (SH3 domain protein). (1175 aa)
	MCF2	MCF.2 cell line derived transforming sequence b. (325 aa)
	TRIO	Trio Rho guanine nucleotide exchange factor. (3035 aa)
	LOC102360420	Uncharacterized protein. (264 aa)
	ARHGEF38	Rho guanine nucleotide exchange factor 38. (800 aa)
	FGD1	FYVE, RhoGEF and PH domain containing 1. (832 aa)
	VAV1	Calponin-homology (CH) domain-containing protein. (85 aa)
	TIAM2	T cell lymphoma invasion and metastasis 2. (1727 aa)
	FGD4	FYVE, RhoGEF and PH domain containing 4. (676 aa)
	PSEN1	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (465 aa)
	TIAM1	T cell lymphoma invasion and metastasis 1. (1606 aa)
	SESTD1	SEC14 and spectrin domain containing 1. (615 aa)
	APH1B	Aph-1 homolog B, gamma-secretase subunit. (258 aa)
	SQSTM1	Sequestosome 1. (441 aa)
	LOC102366450	Uncharacterized protein. (213 aa)
	H3AWC2_LATCH	Uncharacterized protein. (1538 aa)
	H3AWJ7_LATCH	Rho guanine nucleotide exchange factor (GEF) 17. (478 aa)
	LOC102355766	Uncharacterized protein. (524 aa)
	LOC102367521	Uncharacterized protein; Belongs to the peptidase C14A family. (253 aa)
	LOC102359313	Uncharacterized protein. (334 aa)
	ECT2	Epithelial cell transforming 2. (919 aa)
	ARHGEF19	Rho guanine nucleotide exchange factor 19. (920 aa)
	IRAK1	Interleukin 1 receptor associated kinase 1. (673 aa)
	ARHGEF9	Cdc42 guanine nucleotide exchange factor 9. (513 aa)
	H3B3H9_LATCH	Uncharacterized protein. (1311 aa)
	AKAP13	PH domain-containing protein. (644 aa)
	ARHGEF6	Rac/Cdc42 guanine nucleotide exchange factor 6. (772 aa)
	H3B6K7_LATCH	IKKbetaNEMObind domain-containing protein. (241 aa)
	FGD3	FYVE, RhoGEF and PH domain containing 3. (695 aa)
	ARHGEF26	Rho guanine nucleotide exchange factor 26. (899 aa)
	LINGO2	Leucine rich repeat and Ig domain containing 2. (619 aa)
	ARHGEF10L	Rho guanine nucleotide exchange factor 10 like. (477 aa)
	GNA13	G protein subunit alpha 13. (377 aa)
	MYD88	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (286 aa)
	PSEN2	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (458 aa)
	OMG	Oligodendrocyte myelin glycoprotein. (441 aa)
	NFKBIA	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b. (298 aa)
	MCF2L2	MCF.2 cell line derived transforming sequence-like 2. (995 aa)
	LOC102349523	Si:ch1073-396h14.1. (694 aa)
	AATF	Apoptosis antagonizing transcription factor. (555 aa)
	LOC102354637	Core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1a. (386 aa)
	ARHGEF25	Uncharacterized protein. (684 aa)
	NGF	Nerve growth factor; Belongs to the NGF-beta family. (272 aa)
	VAV2	Vav guanine nucleotide exchange factor 2. (519 aa)
	ARHGEF16	Rho guanine nucleotide exchange factor 16. (704 aa)
	M3XHJ5_LATCH	Uncharacterized protein. (158 aa)
	ARHGEF4	Rho guanine nucleotide exchange factor 4. (611 aa)
	ITGB3BP	Uncharacterized protein. (159 aa)
	LOC102348796	Uncharacterized protein. (497 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AATF	LOC102346166	ENSLACP00000020605	ENSLACP00000003410	Apoptosis antagonizing transcription factor.	Ubiquitin-like domain-containing protein.	0.459
AATF	RPS27A	ENSLACP00000020605	ENSLACP00000008678	Apoptosis antagonizing transcription factor.	Ribosomal protein S27a.	0.547
ADAM17	NCSTN	ENSLACP00000010665	ENSLACP00000010981	ADAM metallopeptidase domain 17.	Nicastrin.	0.575
ADAM17	PSEN1	ENSLACP00000010665	ENSLACP00000012775	ADAM metallopeptidase domain 17.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.408
ADAM17	PSENEN	ENSLACP00000010665	ENSLACP00000010134	ADAM metallopeptidase domain 17.	Presenilin enhancer, gamma-secretase subunit.	0.413
AKAP13	ARHGEF16	ENSLACP00000016843	ENSLACP00000021659	PH domain-containing protein.	Rho guanine nucleotide exchange factor 16.	0.537
AKAP13	ECT2	ENSLACP00000016843	ENSLACP00000014447	PH domain-containing protein.	Epithelial cell transforming 2.	0.462
AKAP13	GNA13	ENSLACP00000016843	ENSLACP00000019021	PH domain-containing protein.	G protein subunit alpha 13.	0.472
AKAP13	H3AJ45_LATCH	ENSLACP00000016843	ENSLACP00000009666	PH domain-containing protein.	Uncharacterized protein.	0.530
AKAP13	ITSN1	ENSLACP00000016843	ENSLACP00000011416	PH domain-containing protein.	Intersectin 1 (SH3 domain protein).	0.530
AKAP13	MCF2	ENSLACP00000016843	ENSLACP00000011771	PH domain-containing protein.	MCF.2 cell line derived transforming sequence b.	0.494
AKAP13	TRIO	ENSLACP00000016843	ENSLACP00000011862	PH domain-containing protein.	Trio Rho guanine nucleotide exchange factor.	0.493
APH1B	LOC102360420	ENSLACP00000013738	ENSLACP00000011952	Aph-1 homolog B, gamma-secretase subunit.	Uncharacterized protein.	0.901
APH1B	NCSTN	ENSLACP00000013738	ENSLACP00000010981	Aph-1 homolog B, gamma-secretase subunit.	Nicastrin.	0.989
APH1B	PSEN1	ENSLACP00000013738	ENSLACP00000012775	Aph-1 homolog B, gamma-secretase subunit.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.906
APH1B	PSEN2	ENSLACP00000013738	ENSLACP00000019297	Aph-1 homolog B, gamma-secretase subunit.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.885
APH1B	PSENEN	ENSLACP00000013738	ENSLACP00000010134	Aph-1 homolog B, gamma-secretase subunit.	Presenilin enhancer, gamma-secretase subunit.	0.988
ARHGEF1	ARHGEF25	ENSLACP00000008386	ENSLACP00000021038	Rho guanine nucleotide exchange factor 1.	Uncharacterized protein.	0.431
ARHGEF1	ECT2	ENSLACP00000008386	ENSLACP00000014447	Rho guanine nucleotide exchange factor 1.	Epithelial cell transforming 2.	0.593
ARHGEF1	GNA13	ENSLACP00000008386	ENSLACP00000019021	Rho guanine nucleotide exchange factor 1.	G protein subunit alpha 13.	0.834