(12 nodes) GRB2 events in ERBB2 signaling network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	H3ARU2_LATCH	Uncharacterized protein. (152 aa)
	NRG2	Neuregulin 2. (429 aa)
	HRAS	HRas proto-oncogene, GTPase. (193 aa)
	NRAS	NRAS proto-oncogene, GTPase. (189 aa)
	CSDE1	Cold shock domain containing E1. (854 aa)
	KRAS	KRAS proto-oncogene, GTPase. (189 aa)
	GRB2	Growth factor receptor bound protein 2. (292 aa)
	LOC102357602	Uncharacterized protein. (139 aa)
	NRG1	Neuregulin 1. (409 aa)
	BTC	EGF-like domain-containing protein. (177 aa)
	SOS1	SOS Ras/Rac guanine nucleotide exchange factor 1. (1331 aa)
	H3AMA4_LATCH	Uncharacterized protein. (373 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BTC	GRB2	ENSLACP00000004043	ENSLACP00000000662	EGF-like domain-containing protein.	Growth factor receptor bound protein 2.	0.561
BTC	LOC102357602	ENSLACP00000004043	ENSLACP00000003482	EGF-like domain-containing protein.	Uncharacterized protein.	0.520
BTC	NRG1	ENSLACP00000004043	ENSLACP00000001129	EGF-like domain-containing protein.	Neuregulin 1.	0.520
BTC	NRG2	ENSLACP00000004043	ENSLACP00000015785	EGF-like domain-containing protein.	Neuregulin 2.	0.520
CSDE1	GRB2	ENSLACP00000021001	ENSLACP00000000662	Cold shock domain containing E1.	Growth factor receptor bound protein 2.	0.667
CSDE1	SOS1	ENSLACP00000021001	ENSLACP00000004382	Cold shock domain containing E1.	SOS Ras/Rac guanine nucleotide exchange factor 1.	0.714
GRB2	BTC	ENSLACP00000000662	ENSLACP00000004043	Growth factor receptor bound protein 2.	EGF-like domain-containing protein.	0.561
GRB2	CSDE1	ENSLACP00000000662	ENSLACP00000021001	Growth factor receptor bound protein 2.	Cold shock domain containing E1.	0.667
GRB2	H3ARU2_LATCH	ENSLACP00000000662	ENSLACP00000012363	Growth factor receptor bound protein 2.	Uncharacterized protein.	0.667
GRB2	HRAS	ENSLACP00000000662	ENSLACP00000020973	Growth factor receptor bound protein 2.	HRas proto-oncogene, GTPase.	0.667
GRB2	KRAS	ENSLACP00000000662	ENSLACP00000022976	Growth factor receptor bound protein 2.	KRAS proto-oncogene, GTPase.	0.667
GRB2	LOC102357602	ENSLACP00000000662	ENSLACP00000003482	Growth factor receptor bound protein 2.	Uncharacterized protein.	0.527
GRB2	NRAS	ENSLACP00000000662	ENSLACP00000020975	Growth factor receptor bound protein 2.	NRAS proto-oncogene, GTPase.	0.667
GRB2	NRG1	ENSLACP00000000662	ENSLACP00000001129	Growth factor receptor bound protein 2.	Neuregulin 1.	0.527
GRB2	NRG2	ENSLACP00000000662	ENSLACP00000015785	Growth factor receptor bound protein 2.	Neuregulin 2.	0.527
GRB2	SOS1	ENSLACP00000000662	ENSLACP00000004382	Growth factor receptor bound protein 2.	SOS Ras/Rac guanine nucleotide exchange factor 1.	0.999
H3ARU2_LATCH	GRB2	ENSLACP00000012363	ENSLACP00000000662	Uncharacterized protein.	Growth factor receptor bound protein 2.	0.667
H3ARU2_LATCH	KRAS	ENSLACP00000012363	ENSLACP00000022976	Uncharacterized protein.	KRAS proto-oncogene, GTPase.	0.901
H3ARU2_LATCH	SOS1	ENSLACP00000012363	ENSLACP00000004382	Uncharacterized protein.	SOS Ras/Rac guanine nucleotide exchange factor 1.	0.970
HRAS	GRB2	ENSLACP00000020973	ENSLACP00000000662	HRas proto-oncogene, GTPase.	Growth factor receptor bound protein 2.	0.667