(23 nodes) Cobalamin (Cbl, vitamin B12) transport and metabolism network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	TCN2	DUF4430 domain-containing protein. (431 aa)
	LOC102345892	Zgc:110366. (289 aa)
	LOC102348382	DUF4430 domain-containing protein. (427 aa)
	CDCP2	CUB domain containing protein 2. (514 aa)
	MINDY2	MINDY lysine 48 deubiquitinase 2. (577 aa)
	MTRR	5-methyltetrahydrofolate-homocysteine methyltransferase reductase. (720 aa)
	AMN	Amnion associated transmembrane protein. (492 aa)
	MMUT	Methylmalonyl-CoA mutase. (754 aa)
	MMAB	Corrinoid adenosyltransferase; Belongs to the Cob(I)alamin adenosyltransferase family. (210 aa)
	MINDY1	MINDY lysine 48 deubiquitinase 1. (335 aa)
	LOC102364057	Zgc:101765. (284 aa)
	CUBN	Cubilin. (2936 aa)
	MMAA	Metabolism of cobalamin associated A. (424 aa)
	MMADHC	Metabolism of cobalamin associated D. (311 aa)
	LDLRAP1	Low density lipoprotein receptor adaptor protein 1b. (316 aa)
	ANKRD16	Ankyrin repeat domain 16. (367 aa)
	MMACHC	Metabolism of cobalamin associated C. (242 aa)
	MTR	Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1252 aa)
	LOC102363265	Si:dkey-33m11.8; Belongs to the peptidase S1 family. (256 aa)
	ABCD4	ATP-binding cassette, sub-family D (ALD), member 4. (438 aa)
	LOC102355744	Uncharacterized protein. (237 aa)
	LMBRD1	LMBR1 domain containing 1. (539 aa)
	ADTRP	Uncharacterized protein. (229 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABCD4	LMBRD1	ENSLACP00000021089	ENSLACP00000022938	ATP-binding cassette, sub-family D (ALD), member 4.	LMBR1 domain containing 1.	0.981
ABCD4	MMACHC	ENSLACP00000021089	ENSLACP00000017044	ATP-binding cassette, sub-family D (ALD), member 4.	Metabolism of cobalamin associated C.	0.420
ABCD4	MMUT	ENSLACP00000021089	ENSLACP00000010384	ATP-binding cassette, sub-family D (ALD), member 4.	Methylmalonyl-CoA mutase.	0.687
ABCD4	MTR	ENSLACP00000021089	ENSLACP00000018670	ATP-binding cassette, sub-family D (ALD), member 4.	Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.	0.409
AMN	CDCP2	ENSLACP00000009469	ENSLACP00000007354	Amnion associated transmembrane protein.	CUB domain containing protein 2.	0.903
AMN	CUBN	ENSLACP00000009469	ENSLACP00000012042	Amnion associated transmembrane protein.	Cubilin.	0.994
AMN	LOC102348382	ENSLACP00000009469	ENSLACP00000003805	Amnion associated transmembrane protein.	DUF4430 domain-containing protein.	0.685
AMN	TCN2	ENSLACP00000009469	ENSLACP00000003142	Amnion associated transmembrane protein.	DUF4430 domain-containing protein.	0.773
CDCP2	AMN	ENSLACP00000007354	ENSLACP00000009469	CUB domain containing protein 2.	Amnion associated transmembrane protein.	0.903
CUBN	AMN	ENSLACP00000012042	ENSLACP00000009469	Cubilin.	Amnion associated transmembrane protein.	0.994
CUBN	LOC102348382	ENSLACP00000012042	ENSLACP00000003805	Cubilin.	DUF4430 domain-containing protein.	0.593
CUBN	TCN2	ENSLACP00000012042	ENSLACP00000003142	Cubilin.	DUF4430 domain-containing protein.	0.679
LMBRD1	ABCD4	ENSLACP00000022938	ENSLACP00000021089	LMBR1 domain containing 1.	ATP-binding cassette, sub-family D (ALD), member 4.	0.981
LMBRD1	LOC102345892	ENSLACP00000022938	ENSLACP00000003223	LMBR1 domain containing 1.	Zgc:110366.	0.422
LMBRD1	LOC102348382	ENSLACP00000022938	ENSLACP00000003805	LMBR1 domain containing 1.	DUF4430 domain-containing protein.	0.424
LMBRD1	LOC102364057	ENSLACP00000022938	ENSLACP00000011369	LMBR1 domain containing 1.	Zgc:101765.	0.478
LMBRD1	MMAA	ENSLACP00000022938	ENSLACP00000012156	LMBR1 domain containing 1.	Metabolism of cobalamin associated A.	0.687
LMBRD1	MMAB	ENSLACP00000022938	ENSLACP00000010419	LMBR1 domain containing 1.	Corrinoid adenosyltransferase; Belongs to the Cob(I)alamin adenosyltransferase family.	0.622
LMBRD1	MMACHC	ENSLACP00000022938	ENSLACP00000017044	LMBR1 domain containing 1.	Metabolism of cobalamin associated C.	0.686
LMBRD1	MMADHC	ENSLACP00000022938	ENSLACP00000012305	LMBR1 domain containing 1.	Metabolism of cobalamin associated D.	0.699