(20 nodes) Tie2 Signaling network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ANGPT1	Angiopoietin 1. (499 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa)
	DOK2	Docking protein 2. (545 aa)
	PIK3CB	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1077 aa)
	LOC102351332	Zgc:158659; Belongs to the PI3/PI4-kinase family. (1067 aa)
	H3ARU2_LATCH	Uncharacterized protein. (152 aa)
	TEK	TEK receptor tyrosine kinase. (914 aa)
	ANGPT2	Angiopoietin 2. (493 aa)
	ANGPTL7	Angiopoietin like 7. (350 aa)
	TIE1	Tyrosine kinase with immunoglobulin like and EGF like domains 1. (1143 aa)
	PTPN11	Protein tyrosine phosphatase non-receptor type 11. (586 aa)
	SOS1	SOS Ras/Rac guanine nucleotide exchange factor 1. (1331 aa)
	ANGPT4	Angiopoietin 4. (491 aa)
	GRB2	Growth factor receptor bound protein 2. (292 aa)
	KRAS	KRAS proto-oncogene, GTPase. (189 aa)
	CSDE1	Cold shock domain containing E1. (854 aa)
	NRAS	NRAS proto-oncogene, GTPase. (189 aa)
	HRAS	HRas proto-oncogene, GTPase. (193 aa)
	LOC102352712	Protein tyrosine phosphatase non-receptor type 11b. (553 aa)
	H3BES6_LATCH	Angiopoietin 2b. (498 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANGPT1	TEK	ENSLACP00000010114	ENSLACP00000011084	Angiopoietin 1.	TEK receptor tyrosine kinase.	0.985
ANGPT1	TIE1	ENSLACP00000010114	ENSLACP00000007262	Angiopoietin 1.	Tyrosine kinase with immunoglobulin like and EGF like domains 1.	0.869
ANGPT2	TEK	ENSLACP00000010976	ENSLACP00000011084	Angiopoietin 2.	TEK receptor tyrosine kinase.	0.998
ANGPT2	TIE1	ENSLACP00000010976	ENSLACP00000007262	Angiopoietin 2.	Tyrosine kinase with immunoglobulin like and EGF like domains 1.	0.918
ANGPT4	TEK	ENSLACP00000003144	ENSLACP00000011084	Angiopoietin 4.	TEK receptor tyrosine kinase.	0.985
ANGPT4	TIE1	ENSLACP00000003144	ENSLACP00000007262	Angiopoietin 4.	Tyrosine kinase with immunoglobulin like and EGF like domains 1.	0.869
ANGPTL7	TEK	ENSLACP00000018561	ENSLACP00000011084	Angiopoietin like 7.	TEK receptor tyrosine kinase.	0.748
ANGPTL7	TIE1	ENSLACP00000018561	ENSLACP00000007262	Angiopoietin like 7.	Tyrosine kinase with immunoglobulin like and EGF like domains 1.	0.740
CSDE1	GRB2	ENSLACP00000021001	ENSLACP00000000662	Cold shock domain containing E1.	Growth factor receptor bound protein 2.	0.667
CSDE1	LOC102351332	ENSLACP00000021001	ENSLACP00000013502	Cold shock domain containing E1.	Zgc:158659; Belongs to the PI3/PI4-kinase family.	0.636
CSDE1	LOC102352712	ENSLACP00000021001	ENSLACP00000020958	Cold shock domain containing E1.	Protein tyrosine phosphatase non-receptor type 11b.	0.461
CSDE1	PIK3CA	ENSLACP00000021001	ENSLACP00000017606	Cold shock domain containing E1.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.636
CSDE1	PIK3CB	ENSLACP00000021001	ENSLACP00000014968	Cold shock domain containing E1.	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family.	0.552
CSDE1	PTPN11	ENSLACP00000021001	ENSLACP00000007160	Cold shock domain containing E1.	Protein tyrosine phosphatase non-receptor type 11.	0.461
CSDE1	SOS1	ENSLACP00000021001	ENSLACP00000004382	Cold shock domain containing E1.	SOS Ras/Rac guanine nucleotide exchange factor 1.	0.714
CSDE1	TIE1	ENSLACP00000021001	ENSLACP00000007262	Cold shock domain containing E1.	Tyrosine kinase with immunoglobulin like and EGF like domains 1.	0.414
DOK2	GRB2	ENSLACP00000015658	ENSLACP00000000662	Docking protein 2.	Growth factor receptor bound protein 2.	0.625
DOK2	LOC102352712	ENSLACP00000015658	ENSLACP00000020958	Docking protein 2.	Protein tyrosine phosphatase non-receptor type 11b.	0.421
DOK2	PTPN11	ENSLACP00000015658	ENSLACP00000007160	Docking protein 2.	Protein tyrosine phosphatase non-receptor type 11.	0.421
DOK2	TEK	ENSLACP00000015658	ENSLACP00000011084	Docking protein 2.	TEK receptor tyrosine kinase.	0.784