(14 nodes) Activated NOTCH1 Transmits Signal to the Nucleus network (Latimeria chalumnae)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	DTX4	Deltex E3 ubiquitin ligase 4. (599 aa)
	DTX1	Deltex E3 ubiquitin ligase 1. (322 aa)
	CNTN1	Contactin 1. (1009 aa)
	DNER	Delta/notch like EGF repeat containing. (644 aa)
	MIB1	Mindbomb E3 ubiquitin protein ligase 1. (989 aa)
	RPS27A	Ribosomal protein S27a. (156 aa)
	DLK1	Delta like non-canonical Notch ligand 1. (382 aa)
	NEURL1B	Neuralized E3 ubiquitin protein ligase 1B. (534 aa)
	LOC102357987	Uncharacterized protein. (2519 aa)
	JAG2	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1106 aa)
	NEURL1	Neuralized E3 ubiquitin protein ligase 1. (568 aa)
	NOTCH1	Notch receptor 1. (2494 aa)
	DTX2	Deltex E3 ubiquitin ligase 2. (628 aa)
	ITCH	E3 ubiquitin-protein ligase. (880 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DLK1	LOC102357987	ENSLACP00000011154	ENSLACP00000014598	Delta like non-canonical Notch ligand 1.	Uncharacterized protein.	0.529
DLK1	NOTCH1	ENSLACP00000011154	ENSLACP00000020474	Delta like non-canonical Notch ligand 1.	Notch receptor 1.	0.529
DTX1	ITCH	ENSLACP00000001339	ENSLACP00000021686	Deltex E3 ubiquitin ligase 1.	E3 ubiquitin-protein ligase.	0.683
DTX1	LOC102357987	ENSLACP00000001339	ENSLACP00000014598	Deltex E3 ubiquitin ligase 1.	Uncharacterized protein.	0.944
DTX1	NOTCH1	ENSLACP00000001339	ENSLACP00000020474	Deltex E3 ubiquitin ligase 1.	Notch receptor 1.	0.463
DTX1	RPS27A	ENSLACP00000001339	ENSLACP00000008678	Deltex E3 ubiquitin ligase 1.	Ribosomal protein S27a.	0.594
DTX2	ITCH	ENSLACP00000021034	ENSLACP00000021686	Deltex E3 ubiquitin ligase 2.	E3 ubiquitin-protein ligase.	0.683
DTX2	LOC102357987	ENSLACP00000021034	ENSLACP00000014598	Deltex E3 ubiquitin ligase 2.	Uncharacterized protein.	0.463
DTX2	NOTCH1	ENSLACP00000021034	ENSLACP00000020474	Deltex E3 ubiquitin ligase 2.	Notch receptor 1.	0.463
DTX2	RPS27A	ENSLACP00000021034	ENSLACP00000008678	Deltex E3 ubiquitin ligase 2.	Ribosomal protein S27a.	0.594
DTX4	ITCH	ENSLACP00000002753	ENSLACP00000021686	Deltex E3 ubiquitin ligase 4.	E3 ubiquitin-protein ligase.	0.683
DTX4	LOC102357987	ENSLACP00000002753	ENSLACP00000014598	Deltex E3 ubiquitin ligase 4.	Uncharacterized protein.	0.463
DTX4	NOTCH1	ENSLACP00000002753	ENSLACP00000020474	Deltex E3 ubiquitin ligase 4.	Notch receptor 1.	0.463
DTX4	RPS27A	ENSLACP00000002753	ENSLACP00000008678	Deltex E3 ubiquitin ligase 4.	Ribosomal protein S27a.	0.594
ITCH	DTX1	ENSLACP00000021686	ENSLACP00000001339	E3 ubiquitin-protein ligase.	Deltex E3 ubiquitin ligase 1.	0.683
ITCH	DTX2	ENSLACP00000021686	ENSLACP00000021034	E3 ubiquitin-protein ligase.	Deltex E3 ubiquitin ligase 2.	0.683
ITCH	DTX4	ENSLACP00000021686	ENSLACP00000002753	E3 ubiquitin-protein ligase.	Deltex E3 ubiquitin ligase 4.	0.683
ITCH	RPS27A	ENSLACP00000021686	ENSLACP00000008678	E3 ubiquitin-protein ligase.	Ribosomal protein S27a.	0.956
JAG2	LOC102357987	ENSLACP00000014617	ENSLACP00000014598	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Uncharacterized protein.	0.991
JAG2	MIB1	ENSLACP00000014617	ENSLACP00000008377	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Mindbomb E3 ubiquitin protein ligase 1.	0.404