STRINGSTRING
PSENEN PSENEN LOC102346266 LOC102346266 LOC102360491 LOC102360491 ARPC5L ARPC5L CFL2 CFL2 PSEN2 PSEN2 EFNA5 EFNA5 YES1 YES1 EPHB1 EPHB1 ARPC3 ARPC3 CDC42 CDC42 ROCK2 ROCK2 FNDC3B FNDC3B ROCK1 ROCK1 EPHB3 EPHB3 H3B1U0_LATCH H3B1U0_LATCH LOC102356668 LOC102356668 LOC102363109 LOC102363109 H3AYV3_LATCH H3AYV3_LATCH EFNA2 EFNA2 MMP9 MMP9 EPHA5 EPHA5 EFNA4 EFNA4 WASL WASL H3AX34_LATCH H3AX34_LATCH LOC102360750 LOC102360750 H3AWC2_LATCH H3AWC2_LATCH LOC102361670 LOC102361670 APH1B APH1B ACTR2 ACTR2 FMN2 FMN2 ARPC1B ARPC1B EPHA2 EPHA2 H3AU94_LATCH H3AU94_LATCH LOC102356870 LOC102356870 PSEN1 PSEN1 EFNB2 EFNB2 H3ARI7_LATCH H3ARI7_LATCH LOC102360420 LOC102360420 SDCBP2 SDCBP2 EPHA3-2 EPHA3-2 EFNA1 EFNA1 ITSN1 ITSN1 H3ANX7_LATCH H3ANX7_LATCH NCSTN NCSTN SDC2 SDC2 H2ZU13_LATCH H2ZU13_LATCH H2ZUW3_LATCH H2ZUW3_LATCH LOC102356325 LOC102356325 FNDC3A FNDC3A LOC102354173 LOC102354173 LOC102361226 LOC102361226 H3A0P2_LATCH H3A0P2_LATCH H3A0R0_LATCH H3A0R0_LATCH EPHB4 EPHB4 EPHA7 EPHA7 PAK2 PAK2 ARPC5 ARPC5 EFNA3 EFNA3 RASA1 RASA1 SDCBP SDCBP LOC102357229 LOC102357229 EPHA10 EPHA10 H3A9K3_LATCH H3A9K3_LATCH EFNB1 EFNB1 EPHB6 EPHB6 LYN LYN NGEF NGEF ARHGEF28 ARHGEF28 SRC SRC WAS WAS EPHA3 EPHA3 H3AD06_LATCH H3AD06_LATCH EPHA4 EPHA4 H3ADN2_LATCH H3ADN2_LATCH LOC102361473 LOC102361473 ACTR3 ACTR3 ARPC2 ARPC2 PAK3 PAK3 LOC102346832 LOC102346832 PAK1 PAK1 GRIN2B GRIN2B H3AJ45_LATCH H3AJ45_LATCH H3AJI4_LATCH H3AJI4_LATCH NCK2 NCK2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PSENENPresenilin enhancer, gamma-secretase subunit. (101 aa)
LOC102346266Uncharacterized protein. (503 aa)
LOC102360491ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family. (170 aa)
ARPC5LActin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (150 aa)
CFL2Cofilin 2; Belongs to the actin-binding proteins ADF family. (149 aa)
PSEN2Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (458 aa)
EFNA5Ephrin A5; Belongs to the ephrin family. (185 aa)
YES1Tyrosine-protein kinase. (539 aa)
EPHB1EPH receptor B1. (509 aa)
ARPC3Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (181 aa)
CDC42Cell division cycle 42. (156 aa)
ROCK2Rho associated coiled-coil containing protein kinase 2; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1462 aa)
FNDC3BFibronectin type III domain containing 3B. (944 aa)
ROCK1Rho associated coiled-coil containing protein kinase 1; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1350 aa)
EPHB3EPH receptor B3. (996 aa)
H3B1U0_LATCHUncharacterized protein. (549 aa)
LOC102356668Uncharacterized protein. (671 aa)
LOC102363109Destrin, actin depolymerizing factor; Belongs to the actin-binding proteins ADF family. (168 aa)
H3AYV3_LATCHUncharacterized protein. (962 aa)
EFNA2Ephrin A2; Belongs to the ephrin family. (139 aa)
MMP9Matrix metallopeptidase 9. (682 aa)
EPHA5Uncharacterized protein. (743 aa)
EFNA4Si:dkey-246i14.3; Belongs to the ephrin family. (136 aa)
WASLWASP like actin nucleation promoting factor. (314 aa)
H3AX34_LATCHEph LBD domain-containing protein. (241 aa)
LOC102360750ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family. (180 aa)
H3AWC2_LATCHUncharacterized protein. (1538 aa)
LOC102361670Actin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (376 aa)
APH1BAph-1 homolog B, gamma-secretase subunit. (258 aa)
ACTR2Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (399 aa)
FMN2FH2 domain-containing protein. (245 aa)
ARPC1BActin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (368 aa)
EPHA2Uncharacterized protein. (979 aa)
H3AU94_LATCHEph LBD domain-containing protein. (237 aa)
LOC102356870Uncharacterized protein. (744 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (465 aa)
EFNB2Ephrin B2; Belongs to the ephrin family. (338 aa)
H3ARI7_LATCHEph LBD domain-containing protein. (230 aa)
LOC102360420Uncharacterized protein. (264 aa)
SDCBP2Uncharacterized protein. (300 aa)
EPHA3-2Eph LBD domain-containing protein. (238 aa)
EFNA1Ephrin A1; Belongs to the ephrin family. (176 aa)
ITSN1Intersectin 1 (SH3 domain protein). (1175 aa)
H3ANX7_LATCHUncharacterized protein. (553 aa)
NCSTNNicastrin. (680 aa)
SDC2Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (209 aa)
H2ZU13_LATCHSAM domain-containing protein. (161 aa)
H2ZUW3_LATCHUncharacterized protein. (448 aa)
LOC102356325Eph LBD domain-containing protein. (260 aa)
FNDC3AFibronectin type III domain containing 3A. (1198 aa)
LOC102354173Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (339 aa)
LOC102361226Uncharacterized protein; Belongs to the actin family. (421 aa)
H3A0P2_LATCHFH2 domain-containing protein. (253 aa)
H3A0R0_LATCHEph LBD domain-containing protein. (229 aa)
EPHB4EPH receptor B4. (976 aa)
EPHA7EPH receptor A7. (903 aa)
PAK2Non-specific serine/threonine protein kinase. (521 aa)
ARPC5Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (164 aa)
EFNA3Ephrin-A3b; Belongs to the ephrin family. (186 aa)
RASA1RAS p21 protein activator 1. (878 aa)
SDCBPSyndecan binding protein. (242 aa)
LOC102357229WASP like actin nucleation promoting factor a. (194 aa)
EPHA10Uncharacterized protein. (732 aa)
H3A9K3_LATCHUncharacterized protein. (338 aa)
EFNB1Ephrin B1; Belongs to the ephrin family. (333 aa)
EPHB6EPH receptor B6. (974 aa)
LYNTyrosine-protein kinase. (515 aa)
NGEFNeuronal guanine nucleotide exchange factor. (805 aa)
ARHGEF28Rho guanine nucleotide exchange factor 28. (1318 aa)
SRCTyrosine-protein kinase. (535 aa)
WASUncharacterized protein. (493 aa)
EPHA3Uncharacterized protein. (552 aa)
H3AD06_LATCHUncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. (684 aa)
EPHA4EPH receptor A4. (985 aa)
H3ADN2_LATCHEph LBD domain-containing protein. (281 aa)
LOC102361473Uncharacterized protein. (1211 aa)
ACTR3Actin related protein 3; Belongs to the actin family. (418 aa)
ARPC2Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (308 aa)
PAK3Protein kinase domain-containing protein. (580 aa)
LOC102346832Si:dkey-280e21.3. (431 aa)
PAK1Non-specific serine/threonine protein kinase. (545 aa)
GRIN2BGlutamate ionotropic receptor NMDA type subunit 2B. (1450 aa)
H3AJ45_LATCHUncharacterized protein. (651 aa)
H3AJI4_LATCHUncharacterized protein. (272 aa)
NCK2Cytoplasmic protein. (380 aa)
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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