(30 nodes) Notch-HLH transcription pathway network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CRB2	Uncharacterized protein. (1473 aa)
	HDAC7	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (873 aa)
	CREBBP	CREB binding protein. (2411 aa)
	MAML2	Mastermind like transcriptional coactivator 2. (954 aa)
	NCOR1	Nuclear receptor corepressor 1. (2480 aa)
	RBPJL	Recombination signal binding protein for immunoglobulin kappa J region like. (512 aa)
	CRB1	Crumbs cell polarity complex component 1. (1366 aa)
	KAT2B	Histone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (793 aa)
	HDAC6	Histone deacetylase 6. (1113 aa)
	RBPJ	Recombination signal binding protein for immunoglobulin kappa J region. (487 aa)
	HDAC4	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1086 aa)
	H3AG88_LATCH	MamL-1 domain-containing protein. (130 aa)
	HDAC11	Histone deacetylase 11. (389 aa)
	LOC102349863	Histone deacetylase 12. (323 aa)
	HDAC3	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (428 aa)
	LOC102363322	Uncharacterized protein. (509 aa)
	MAML3	Mastermind like transcriptional coactivator 3. (943 aa)
	KAT2A	Lysine acetyltransferase 2A. (740 aa)
	MAML1	Mastermind like transcriptional coactivator 1. (1039 aa)
	HDAC8	Histone deacetylase 8; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (379 aa)
	LOC102357987	Uncharacterized protein. (2519 aa)
	SNW1	SNW domain containing 1. (536 aa)
	HDAC1	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (484 aa)
	NCOR2	Nuclear receptor corepressor 2. (2350 aa)
	HDAC9	Histone deacetylase 9. (594 aa)
	HDAC5	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1084 aa)
	HDAC10	Histone deacetylase 10. (677 aa)
	TBL1XR1	Transducin beta like 1 X-linked receptor 1. (515 aa)
	NOTCH1	Notch receptor 1. (2494 aa)
	MAMLD1	Mastermind like domain containing 1. (958 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CRB1	RBPJ	ENSLACP00000006909	ENSLACP00000008245	Crumbs cell polarity complex component 1.	Recombination signal binding protein for immunoglobulin kappa J region.	0.418
CRB1	RBPJL	ENSLACP00000006909	ENSLACP00000006489	Crumbs cell polarity complex component 1.	Recombination signal binding protein for immunoglobulin kappa J region like.	0.415
CRB2	RBPJ	ENSLACP00000021515	ENSLACP00000008245	Uncharacterized protein.	Recombination signal binding protein for immunoglobulin kappa J region.	0.418
CRB2	RBPJL	ENSLACP00000021515	ENSLACP00000006489	Uncharacterized protein.	Recombination signal binding protein for immunoglobulin kappa J region like.	0.415
CREBBP	HDAC1	ENSLACP00000023096	ENSLACP00000015194	CREB binding protein.	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.746
CREBBP	HDAC10	ENSLACP00000023096	ENSLACP00000018610	CREB binding protein.	Histone deacetylase 10.	0.653
CREBBP	HDAC11	ENSLACP00000023096	ENSLACP00000010626	CREB binding protein.	Histone deacetylase 11.	0.492
CREBBP	HDAC3	ENSLACP00000023096	ENSLACP00000011092	CREB binding protein.	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	0.811
CREBBP	HDAC4	ENSLACP00000023096	ENSLACP00000008432	CREB binding protein.	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	0.497
CREBBP	HDAC5	ENSLACP00000023096	ENSLACP00000018356	CREB binding protein.	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	0.497
CREBBP	HDAC6	ENSLACP00000023096	ENSLACP00000007918	CREB binding protein.	Histone deacetylase 6.	0.497
CREBBP	HDAC7	ENSLACP00000023096	ENSLACP00000021749	CREB binding protein.	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	0.497
CREBBP	HDAC8	ENSLACP00000023096	ENSLACP00000012893	CREB binding protein.	Histone deacetylase 8; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.746
CREBBP	HDAC9	ENSLACP00000023096	ENSLACP00000017705	CREB binding protein.	Histone deacetylase 9.	0.497
CREBBP	KAT2A	ENSLACP00000023096	ENSLACP00000012334	CREB binding protein.	Lysine acetyltransferase 2A.	0.847
CREBBP	KAT2B	ENSLACP00000023096	ENSLACP00000007242	CREB binding protein.	Histone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily.	0.990
CREBBP	LOC102349863	ENSLACP00000023096	ENSLACP00000010878	CREB binding protein.	Histone deacetylase 12.	0.485
CREBBP	LOC102357987	ENSLACP00000023096	ENSLACP00000014598	CREB binding protein.	Uncharacterized protein.	0.607
CREBBP	LOC102363322	ENSLACP00000023096	ENSLACP00000011640	CREB binding protein.	Uncharacterized protein.	0.533
CREBBP	MAML1	ENSLACP00000023096	ENSLACP00000012398	CREB binding protein.	Mastermind like transcriptional coactivator 1.	0.956