(71 nodes) Semaphorin interactions network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	DPYSL4	Dihydropyrimidinase like 4. (692 aa)
	FARP2	FERM, ARH/RhoGEF and pleckstrin domain protein 2. (697 aa)
	HSP90AB1	Heat shock protein 90 alpha family class B member 1. (734 aa)
	ARHGAP35	Rho GTPase activating protein 35b. (1487 aa)
	NRP1	Neuropilin; Belongs to the neuropilin family. (928 aa)
	TLN1	Talin 1. (2546 aa)
	LOC102366200	Uncharacterized protein; Belongs to the semaphorin family. (627 aa)
	H3AM41_LATCH	G8 domain-containing protein. (1861 aa)
	LOC102345793	Si:dkeyp-92c9.2. (294 aa)
	H3AJV8_LATCH	Beta_helix domain-containing protein. (504 aa)
	CDK5	Cyclin dependent kinase 5. (290 aa)
	H3AIX4_LATCH	Uncharacterized protein. (418 aa)
	PAK1	Non-specific serine/threonine protein kinase. (545 aa)
	DPYSL3	Dihydropyrimidinase like 3. (663 aa)
	PAK3	Protein kinase domain-containing protein. (580 aa)
	LOC102350273	Uncharacterized protein. (196 aa)
	GSK3A	Glycogen synthase kinase 3 alpha a; Belongs to the protein kinase superfamily. (463 aa)
	PLXNA3	Sema domain-containing protein. (698 aa)
	LOC102365245	Zgc:103559. (464 aa)
	LOC102366586	Sema domain-containing protein; Belongs to the semaphorin family. (620 aa)
	LOC102360491	ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family. (170 aa)
	SEMA4B	Semaphorin 4B; Belongs to the semaphorin family. (825 aa)
	PLXNA2	Plexin A2. (1897 aa)
	LIMK1	LIM domain kinase 1. (613 aa)
	CFL2	Cofilin 2; Belongs to the actin-binding proteins ADF family. (149 aa)
	RHOC	Ras homolog family member Cb. (156 aa)
	DPYSL2	Dihydropyrimidinase like 2. (677 aa)
	LOC102365809	Si:ch211-113g11.6; Belongs to the semaphorin family. (631 aa)
	RHOA	Uncharacterized protein. (193 aa)
	LOC102347479	Zgc:113162. (325 aa)
	RND1	Rho family GTPase 1. (321 aa)
	SEMA6A	Semaphorin 6A; Belongs to the semaphorin family. (1020 aa)
	LIMK2	LIM domain kinase 2. (430 aa)
	CDK5R2	Cyclin-dependent kinase 5 activator. (325 aa)
	SEMA3B	Semaphorin 3B; Belongs to the semaphorin family. (767 aa)
	PLXNA1	Plexin A1. (1387 aa)
	PKHD1L1	PKHD1 like 1. (4001 aa)
	H3A8K8_LATCH	Sema domain-containing protein. (2101 aa)
	LOC102348524	Uncharacterized protein. (193 aa)
	PAK2	Non-specific serine/threonine protein kinase. (521 aa)
	SEMA6D	Semaphorin 6D; Belongs to the semaphorin family. (1076 aa)
	LOC102366847	Uncharacterized protein; Belongs to the semaphorin family. (542 aa)
	SEMA4D	Semaphorin 4D; Belongs to the semaphorin family. (862 aa)
	CRMP1	Collapsin response mediator protein 1. (659 aa)
	DPYS	Dihydropyrimidinase. (514 aa)
	H3A2E1_LATCH	Plexin_cytopl domain-containing protein. (415 aa)
	SEMA6C	Semaphorin 6C; Belongs to the semaphorin family. (1059 aa)
	SEMA6B	Sema domain-containing protein; Belongs to the semaphorin family. (911 aa)
	PTPRC	Protein tyrosine phosphatase receptor type C. (830 aa)
	PLXNB1	Plexin B1. (2146 aa)
	PLXNA3-2	Plexin A3. (1193 aa)
	LOC102357218	Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 1. (730 aa)
	SEMA3E	Semaphorin 3E; Belongs to the semaphorin family. (739 aa)
	ROCK2	Rho associated coiled-coil containing protein kinase 2; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1462 aa)
	H3B672_LATCH	Uncharacterized protein; Belongs to the semaphorin family. (507 aa)
	PLXNB2	Plexin B2. (1835 aa)
	PKHD1	PKHD1 ciliary IPT domain containing fibrocystin/polyductin. (2690 aa)
	HSP90AA1	Heat shock protein 90 alpha family class A member 1. (725 aa)
	ROCK1	Rho associated coiled-coil containing protein kinase 1; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1350 aa)
	H3B2A9_LATCH	Uncharacterized protein. (97 aa)
	SEMA3A	Semaphorin 3A; Belongs to the semaphorin family. (635 aa)
	TLN2	Talin 2. (1962 aa)
	SEMA4A	Sema domain-containing protein; Belongs to the semaphorin family. (758 aa)
	LOC102363109	Destrin, actin depolymerizing factor; Belongs to the actin-binding proteins ADF family. (168 aa)
	MET	MET proto-oncogene, receptor tyrosine kinase. (1385 aa)
	TLNRD1	Talin rod domain containing 1. (358 aa)
	LOC102360750	ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family. (180 aa)
	PLXND1	Plexin D1. (1875 aa)
	GSK3B	Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (420 aa)
	CDK5R1	Cyclin-dependent kinase 5 activator. (306 aa)
	LOC102347877	Uncharacterized protein. (1033 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARHGAP35	H3A8K8_LATCH	ENSLACP00000011704	ENSLACP00000005979	Rho GTPase activating protein 35b.	Sema domain-containing protein.	0.474
ARHGAP35	LOC102348524	ENSLACP00000011704	ENSLACP00000004714	Rho GTPase activating protein 35b.	Uncharacterized protein.	0.980
ARHGAP35	LOC102350273	ENSLACP00000011704	ENSLACP00000007743	Rho GTPase activating protein 35b.	Uncharacterized protein.	0.815
ARHGAP35	LOC102366200	ENSLACP00000011704	ENSLACP00000010997	Rho GTPase activating protein 35b.	Uncharacterized protein; Belongs to the semaphorin family.	0.515
ARHGAP35	MET	ENSLACP00000011704	ENSLACP00000015263	Rho GTPase activating protein 35b.	MET proto-oncogene, receptor tyrosine kinase.	0.668
ARHGAP35	PLXNB1	ENSLACP00000011704	ENSLACP00000002901	Rho GTPase activating protein 35b.	Plexin B1.	0.474
ARHGAP35	PLXNB2	ENSLACP00000011704	ENSLACP00000017329	Rho GTPase activating protein 35b.	Plexin B2.	0.474
ARHGAP35	RHOA	ENSLACP00000011704	ENSLACP00000019259	Rho GTPase activating protein 35b.	Uncharacterized protein.	0.980
ARHGAP35	RHOC	ENSLACP00000011704	ENSLACP00000020380	Rho GTPase activating protein 35b.	Ras homolog family member Cb.	0.815
ARHGAP35	RND1	ENSLACP00000011704	ENSLACP00000019147	Rho GTPase activating protein 35b.	Rho family GTPase 1.	0.882
ARHGAP35	ROCK1	ENSLACP00000011704	ENSLACP00000016034	Rho GTPase activating protein 35b.	Rho associated coiled-coil containing protein kinase 1; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.	0.407
ARHGAP35	SEMA4D	ENSLACP00000011704	ENSLACP00000004027	Rho GTPase activating protein 35b.	Semaphorin 4D; Belongs to the semaphorin family.	0.515
CDK5	CDK5R1	ENSLACP00000009607	ENSLACP00000012210	Cyclin dependent kinase 5.	Cyclin-dependent kinase 5 activator.	0.949
CDK5	CDK5R2	ENSLACP00000009607	ENSLACP00000018721	Cyclin dependent kinase 5.	Cyclin-dependent kinase 5 activator.	0.949
CDK5	CRMP1	ENSLACP00000009607	ENSLACP00000004009	Cyclin dependent kinase 5.	Collapsin response mediator protein 1.	0.692
CDK5	DPYS	ENSLACP00000009607	ENSLACP00000003896	Cyclin dependent kinase 5.	Dihydropyrimidinase.	0.593
CDK5	DPYSL2	ENSLACP00000009607	ENSLACP00000020176	Cyclin dependent kinase 5.	Dihydropyrimidinase like 2.	0.593
CDK5	DPYSL3	ENSLACP00000009607	ENSLACP00000008500	Cyclin dependent kinase 5.	Dihydropyrimidinase like 3.	0.593
CDK5	DPYSL4	ENSLACP00000009607	ENSLACP00000011966	Cyclin dependent kinase 5.	Dihydropyrimidinase like 4.	0.670
CDK5	GSK3A	ENSLACP00000009607	ENSLACP00000007367	Cyclin dependent kinase 5.	Glycogen synthase kinase 3 alpha a; Belongs to the protein kinase superfamily.	0.600