(15 nodes) Negative regulation of TCF-dependent signaling by WNT ligand antagonists network (Latimeria chalumnae)

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second shell of interactors

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Known Interactions

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Predicted Interactions

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Your Input:
	DKK4	Dickkopf WNT signaling pathway inhibitor 4. (222 aa)
	LOC102358266	Dickkopf WNT signaling pathway inhibitor 1b. (261 aa)
	DKK2	Dickkopf WNT signaling pathway inhibitor 2. (212 aa)
	SFRP2	Secreted frizzled related protein 2. (294 aa)
	SFRP1	NTR domain-containing protein. (128 aa)
	SFRP1-2	FZ domain-containing protein. (203 aa)
	SOST	Sclerostin. (210 aa)
	WIF1	WNT inhibitory factor 1. (379 aa)
	SFRP5	Secreted frizzled related protein 5. (309 aa)
	KREMEN1	Kringle containing transmembrane protein 1. (249 aa)
	LOC102356742	Sizzled. (295 aa)
	LOC102355199	Uncharacterized protein. (301 aa)
	LOC102354118	Dickkopf_N domain-containing protein. (243 aa)
	LRP6	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1615 aa)
	LRP5	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1598 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DKK2	KREMEN1	ENSLACP00000006397	ENSLACP00000017734	Dickkopf WNT signaling pathway inhibitor 2.	Kringle containing transmembrane protein 1.	0.725
DKK2	LOC102358266	ENSLACP00000006397	ENSLACP00000005525	Dickkopf WNT signaling pathway inhibitor 2.	Dickkopf WNT signaling pathway inhibitor 1b.	0.531
DKK2	LRP5	ENSLACP00000006397	ENSLACP00000021154	Dickkopf WNT signaling pathway inhibitor 2.	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	0.969
DKK2	LRP6	ENSLACP00000006397	ENSLACP00000020844	Dickkopf WNT signaling pathway inhibitor 2.	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	0.969
DKK2	SFRP1	ENSLACP00000006397	ENSLACP00000009842	Dickkopf WNT signaling pathway inhibitor 2.	NTR domain-containing protein.	0.413
DKK2	SFRP1-2	ENSLACP00000006397	ENSLACP00000011164	Dickkopf WNT signaling pathway inhibitor 2.	FZ domain-containing protein.	0.413
DKK2	SFRP2	ENSLACP00000006397	ENSLACP00000007301	Dickkopf WNT signaling pathway inhibitor 2.	Secreted frizzled related protein 2.	0.536
DKK2	WIF1	ENSLACP00000006397	ENSLACP00000012496	Dickkopf WNT signaling pathway inhibitor 2.	WNT inhibitory factor 1.	0.612
DKK4	KREMEN1	ENSLACP00000016408	ENSLACP00000017734	Dickkopf WNT signaling pathway inhibitor 4.	Kringle containing transmembrane protein 1.	0.795
DKK4	LOC102358266	ENSLACP00000016408	ENSLACP00000005525	Dickkopf WNT signaling pathway inhibitor 4.	Dickkopf WNT signaling pathway inhibitor 1b.	0.543
DKK4	LRP5	ENSLACP00000016408	ENSLACP00000021154	Dickkopf WNT signaling pathway inhibitor 4.	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	0.981
DKK4	LRP6	ENSLACP00000016408	ENSLACP00000020844	Dickkopf WNT signaling pathway inhibitor 4.	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	0.981
DKK4	WIF1	ENSLACP00000016408	ENSLACP00000012496	Dickkopf WNT signaling pathway inhibitor 4.	WNT inhibitory factor 1.	0.470
KREMEN1	DKK2	ENSLACP00000017734	ENSLACP00000006397	Kringle containing transmembrane protein 1.	Dickkopf WNT signaling pathway inhibitor 2.	0.725
KREMEN1	DKK4	ENSLACP00000017734	ENSLACP00000016408	Kringle containing transmembrane protein 1.	Dickkopf WNT signaling pathway inhibitor 4.	0.795
KREMEN1	LOC102354118	ENSLACP00000017734	ENSLACP00000019592	Kringle containing transmembrane protein 1.	Dickkopf_N domain-containing protein.	0.725
KREMEN1	LOC102358266	ENSLACP00000017734	ENSLACP00000005525	Kringle containing transmembrane protein 1.	Dickkopf WNT signaling pathway inhibitor 1b.	0.962
KREMEN1	LRP5	ENSLACP00000017734	ENSLACP00000021154	Kringle containing transmembrane protein 1.	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	0.929
KREMEN1	LRP6	ENSLACP00000017734	ENSLACP00000020844	Kringle containing transmembrane protein 1.	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	0.932
LOC102354118	KREMEN1	ENSLACP00000019592	ENSLACP00000017734	Dickkopf_N domain-containing protein.	Kringle containing transmembrane protein 1.	0.725