(9 nodes) CD28 dependent Vav1 pathway network (Latimeria chalumnae)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	GRB2	Growth factor receptor bound protein 2. (292 aa)
	PAK2	Non-specific serine/threonine protein kinase. (521 aa)
	PAK3	Protein kinase domain-containing protein. (580 aa)
	PAK1	Non-specific serine/threonine protein kinase. (545 aa)
	CD28	Ig-like domain-containing protein. (202 aa)
	CD276	CD276 molecule. (324 aa)
	CDC42	Cell division cycle 42. (156 aa)
	LOC102354637	Core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1a. (386 aa)
	M3XIM8_LATCH	Ig-like domain-containing protein. (241 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CD276	CD28	ENSLACP00000017684	ENSLACP00000010862	CD276 molecule.	Ig-like domain-containing protein.	0.437
CD28	CD276	ENSLACP00000010862	ENSLACP00000017684	Ig-like domain-containing protein.	CD276 molecule.	0.437
CD28	GRB2	ENSLACP00000010862	ENSLACP00000000662	Ig-like domain-containing protein.	Growth factor receptor bound protein 2.	0.410
CD28	M3XIM8_LATCH	ENSLACP00000010862	ENSLACP00000022584	Ig-like domain-containing protein.	Ig-like domain-containing protein.	0.437
CDC42	GRB2	ENSLACP00000018010	ENSLACP00000000662	Cell division cycle 42.	Growth factor receptor bound protein 2.	0.807
CDC42	PAK1	ENSLACP00000018010	ENSLACP00000008886	Cell division cycle 42.	Non-specific serine/threonine protein kinase.	0.995
CDC42	PAK2	ENSLACP00000018010	ENSLACP00000004711	Cell division cycle 42.	Non-specific serine/threonine protein kinase.	0.986
CDC42	PAK3	ENSLACP00000018010	ENSLACP00000008469	Cell division cycle 42.	Protein kinase domain-containing protein.	0.954
GRB2	CD28	ENSLACP00000000662	ENSLACP00000010862	Growth factor receptor bound protein 2.	Ig-like domain-containing protein.	0.410
GRB2	CDC42	ENSLACP00000000662	ENSLACP00000018010	Growth factor receptor bound protein 2.	Cell division cycle 42.	0.807
GRB2	PAK1	ENSLACP00000000662	ENSLACP00000008886	Growth factor receptor bound protein 2.	Non-specific serine/threonine protein kinase.	0.623
GRB2	PAK2	ENSLACP00000000662	ENSLACP00000004711	Growth factor receptor bound protein 2.	Non-specific serine/threonine protein kinase.	0.608
GRB2	PAK3	ENSLACP00000000662	ENSLACP00000008469	Growth factor receptor bound protein 2.	Protein kinase domain-containing protein.	0.623
M3XIM8_LATCH	CD28	ENSLACP00000022584	ENSLACP00000010862	Ig-like domain-containing protein.	Ig-like domain-containing protein.	0.437
PAK1	CDC42	ENSLACP00000008886	ENSLACP00000018010	Non-specific serine/threonine protein kinase.	Cell division cycle 42.	0.995
PAK1	GRB2	ENSLACP00000008886	ENSLACP00000000662	Non-specific serine/threonine protein kinase.	Growth factor receptor bound protein 2.	0.623
PAK1	PAK2	ENSLACP00000008886	ENSLACP00000004711	Non-specific serine/threonine protein kinase.	Non-specific serine/threonine protein kinase.	0.703
PAK2	CDC42	ENSLACP00000004711	ENSLACP00000018010	Non-specific serine/threonine protein kinase.	Cell division cycle 42.	0.986
PAK2	GRB2	ENSLACP00000004711	ENSLACP00000000662	Non-specific serine/threonine protein kinase.	Growth factor receptor bound protein 2.	0.608
PAK2	PAK1	ENSLACP00000004711	ENSLACP00000008886	Non-specific serine/threonine protein kinase.	Non-specific serine/threonine protein kinase.	0.703