(43 nodes) N-glycan trimming in the ER and Calnexin/Calreticulin cycle network (Latimeria chalumnae)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	MARCHF10	Membrane associated ring-CH-type finger 10. (782 aa)
	MARCHF6	Membrane associated ring-CH-type finger 6. (775 aa)
	MARCHF11	Membrane associated ring-CH-type finger 11. (224 aa)
	TRIM54	Uncharacterized protein. (366 aa)
	KXD1	Ubiquitin-like domain-containing protein. (231 aa)
	RNF103	Ring finger protein 103. (678 aa)
	DERL1	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (254 aa)
	RPS27A	Ribosomal protein S27a. (156 aa)
	MARCHF7	Membrane associated ring-CH-type finger 7. (733 aa)
	MARCHF1	Membrane associated ring-CH-type finger 1. (496 aa)
	MARCHF3	Membrane associated ring-CH-type finger 3. (252 aa)
	UGGT2	UDP-glucose glycoprotein glucosyltransferase 2. (1295 aa)
	MARCHF8	Membrane associated ring-CH-type finger 8. (476 aa)
	MOGS	Mannosyl-oligosaccharide glucosidase. (839 aa)
	LOC102350907	Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa)
	LOC106706091	Uncharacterized protein. (503 aa)
	LOC102346166	Ubiquitin-like domain-containing protein. (95 aa)
	TRIM55	Tripartite motif containing 55. (531 aa)
	CLGN	Calmegin. (619 aa)
	H2ZYM3_LATCH	RING-type domain-containing protein. (81 aa)
	NGLY1	N-glycanase 1. (659 aa)
	LOC102360381	Uncharacterized protein. (300 aa)
	RNF139	Ring finger protein 139. (661 aa)
	VCP	Valosin containing protein. (801 aa)
	PDIA3	Protein disulfide-isomerase. (497 aa)
	TRIM13	Tripartite motif containing 13. (414 aa)
	PSMC1	Proteasome 26S subunit, ATPase 1; Belongs to the AAA ATPase family. (451 aa)
	UGGT1	UDP-glucose glycoprotein glucosyltransferase 1. (1519 aa)
	LOC102365663	Zgc:136908; Belongs to the AAA ATPase family. (697 aa)
	EDEM1	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (654 aa)
	SPATA5	Spermatogenesis associated 5. (795 aa)
	H3BCE5_LATCH	RING-CH-type domain-containing protein. (214 aa)
	MAN1B1	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (641 aa)
	GANAB	Glucosidase II alpha subunit; Belongs to the glycosyl hydrolase 31 family. (942 aa)
	MARCHF9	Membrane associated ring-CH-type finger 9. (339 aa)
	UBXN1	UBX domain protein 1. (320 aa)
	EDEM2	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (576 aa)
	CALR3	Calreticulin. (416 aa)
	ENGASE	Endo-beta-N-acetylglucosaminidase. (624 aa)
	EDEM3	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (929 aa)
	MARCHF2	Membrane associated ring-CH-type finger 2. (245 aa)
	SPATA5L1	Spermatogenesis associated 5 like 1. (792 aa)
	CANX	Calnexin. (625 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CALR3	CANX	ENSLACP00000020782	ENSLACP00000012732	Calreticulin.	Calnexin.	0.880
CALR3	CLGN	ENSLACP00000020782	ENSLACP00000002710	Calreticulin.	Calmegin.	0.864
CALR3	DERL1	ENSLACP00000020782	ENSLACP00000008715	Calreticulin.	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	0.458
CALR3	EDEM1	ENSLACP00000020782	ENSLACP00000018295	Calreticulin.	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family.	0.478
CALR3	GANAB	ENSLACP00000020782	ENSLACP00000019643	Calreticulin.	Glucosidase II alpha subunit; Belongs to the glycosyl hydrolase 31 family.	0.635
CALR3	LOC106706091	ENSLACP00000020782	ENSLACP00000003447	Calreticulin.	Uncharacterized protein.	0.971
CALR3	MOGS	ENSLACP00000020782	ENSLACP00000004122	Calreticulin.	Mannosyl-oligosaccharide glucosidase.	0.539
CALR3	PDIA3	ENSLACP00000020782	ENSLACP00000015133	Calreticulin.	Protein disulfide-isomerase.	0.998
CALR3	UGGT1	ENSLACP00000020782	ENSLACP00000017108	Calreticulin.	UDP-glucose glycoprotein glucosyltransferase 1.	0.462
CALR3	UGGT2	ENSLACP00000020782	ENSLACP00000006209	Calreticulin.	UDP-glucose glycoprotein glucosyltransferase 2.	0.462
CANX	CALR3	ENSLACP00000012732	ENSLACP00000020782	Calnexin.	Calreticulin.	0.880
CANX	DERL1	ENSLACP00000012732	ENSLACP00000008715	Calnexin.	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	0.469
CANX	EDEM1	ENSLACP00000012732	ENSLACP00000018295	Calnexin.	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family.	0.836
CANX	EDEM2	ENSLACP00000012732	ENSLACP00000020554	Calnexin.	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family.	0.541
CANX	GANAB	ENSLACP00000012732	ENSLACP00000019643	Calnexin.	Glucosidase II alpha subunit; Belongs to the glycosyl hydrolase 31 family.	0.880
CANX	LOC102360381	ENSLACP00000012732	ENSLACP00000001920	Calnexin.	Uncharacterized protein.	0.881
CANX	LOC102365663	ENSLACP00000012732	ENSLACP00000018103	Calnexin.	Zgc:136908; Belongs to the AAA ATPase family.	0.461
CANX	LOC106706091	ENSLACP00000012732	ENSLACP00000003447	Calnexin.	Uncharacterized protein.	0.757
CANX	MAN1B1	ENSLACP00000012732	ENSLACP00000019639	Calnexin.	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family.	0.487
CANX	MOGS	ENSLACP00000012732	ENSLACP00000004122	Calnexin.	Mannosyl-oligosaccharide glucosidase.	0.833