(23 nodes) FRS-mediated FGFR4 signaling network (Latimeria chalumnae)

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Your Input:
	FGF19	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (217 aa)
	GRB2	Growth factor receptor bound protein 2. (292 aa)
	SOS1	SOS Ras/Rac guanine nucleotide exchange factor 1. (1331 aa)
	LOC102356182	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (196 aa)
	FRS2	Fibroblast growth factor receptor substrate 2. (502 aa)
	PTPN11	Protein tyrosine phosphatase non-receptor type 11. (586 aa)
	FGF8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
	FGF16	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa)
	H3ARU2_LATCH	Uncharacterized protein. (152 aa)
	FGF4	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (195 aa)
	FGF20	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	FGF1	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
	FGF18	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa)
	FRS3	Fibroblast growth factor receptor substrate 3. (516 aa)
	FGF2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
	FGF23	Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (249 aa)
	FGF6	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
	LOC102352712	Protein tyrosine phosphatase non-receptor type 11b. (553 aa)
	HRAS	HRas proto-oncogene, GTPase. (193 aa)
	NRAS	NRAS proto-oncogene, GTPase. (189 aa)
	CSDE1	Cold shock domain containing E1. (854 aa)
	FGFR4	Fibroblast growth factor receptor. (810 aa)
	KRAS	KRAS proto-oncogene, GTPase. (189 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CSDE1	FGF1	ENSLACP00000021001	ENSLACP00000015106	Cold shock domain containing E1.	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	0.400
CSDE1	FGF18	ENSLACP00000021001	ENSLACP00000015472	Cold shock domain containing E1.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.417
CSDE1	FGF4	ENSLACP00000021001	ENSLACP00000014225	Cold shock domain containing E1.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.431
CSDE1	FGF8	ENSLACP00000021001	ENSLACP00000007843	Cold shock domain containing E1.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.401
CSDE1	FGFR4	ENSLACP00000021001	ENSLACP00000021882	Cold shock domain containing E1.	Fibroblast growth factor receptor.	0.426
CSDE1	FRS2	ENSLACP00000021001	ENSLACP00000007102	Cold shock domain containing E1.	Fibroblast growth factor receptor substrate 2.	0.413
CSDE1	FRS3	ENSLACP00000021001	ENSLACP00000015855	Cold shock domain containing E1.	Fibroblast growth factor receptor substrate 3.	0.411
CSDE1	GRB2	ENSLACP00000021001	ENSLACP00000000662	Cold shock domain containing E1.	Growth factor receptor bound protein 2.	0.667
CSDE1	LOC102352712	ENSLACP00000021001	ENSLACP00000020958	Cold shock domain containing E1.	Protein tyrosine phosphatase non-receptor type 11b.	0.461
CSDE1	LOC102356182	ENSLACP00000021001	ENSLACP00000006376	Cold shock domain containing E1.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.417
CSDE1	PTPN11	ENSLACP00000021001	ENSLACP00000007160	Cold shock domain containing E1.	Protein tyrosine phosphatase non-receptor type 11.	0.461
CSDE1	SOS1	ENSLACP00000021001	ENSLACP00000004382	Cold shock domain containing E1.	SOS Ras/Rac guanine nucleotide exchange factor 1.	0.714
FGF1	CSDE1	ENSLACP00000015106	ENSLACP00000021001	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	Cold shock domain containing E1.	0.400
FGF1	FGF16	ENSLACP00000015106	ENSLACP00000011423	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.415
FGF1	FGF18	ENSLACP00000015106	ENSLACP00000015472	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.554
FGF1	FGF19	ENSLACP00000015106	ENSLACP00000014596	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.561
FGF1	FGF20	ENSLACP00000015106	ENSLACP00000014835	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.418
FGF1	FGF23	ENSLACP00000015106	ENSLACP00000020506	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family.	0.702
FGF1	FGF4	ENSLACP00000015106	ENSLACP00000014225	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.655
FGF1	FGF6	ENSLACP00000015106	ENSLACP00000020525	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.460