(21 nodes) Translesion synthesis by POLK network (Latimeria chalumnae)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	REV3L	REV3 like, DNA directed polymerase zeta catalytic subunit. (2836 aa)
	KXD1	Ubiquitin-like domain-containing protein. (231 aa)
	RCBTB2	RCC1 and BTB domain containing protein 2. (413 aa)
	POLK	DNA polymerase kappa. (873 aa)
	PCNA	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa)
	RPA1	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (495 aa)
	RPS27A	Ribosomal protein S27a. (156 aa)
	RFC1	Replication factor C subunit 1. (1152 aa)
	LOC102346166	Ubiquitin-like domain-containing protein. (95 aa)
	LOC102350907	Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa)
	RFC5	Replication factor C subunit 5. (333 aa)
	RFC4	Replication factor C subunit 4. (360 aa)
	RFC2	Replication factor C subunit 2. (396 aa)
	MAD2L2	Mitotic arrest deficient 2 like 2. (212 aa)
	MEIOB	Meiosis specific with OB-fold. (470 aa)
	ATAD5	ATPase family AAA domain containing 5. (1828 aa)
	RCBTB1	RCC1 and BTB domain containing protein 1. (531 aa)
	REV1	DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family. (1270 aa)
	RFC3	Replication factor C subunit 3. (237 aa)
	H3ANK2_LATCH	DNA_pol_B_exo1 domain-containing protein. (225 aa)
	RPA3	Replication protein A3. (121 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATAD5	H3ANK2_LATCH	ENSLACP00000019203	ENSLACP00000011223	ATPase family AAA domain containing 5.	DNA_pol_B_exo1 domain-containing protein.	0.726
ATAD5	LOC102346166	ENSLACP00000019203	ENSLACP00000003410	ATPase family AAA domain containing 5.	Ubiquitin-like domain-containing protein.	0.554
ATAD5	MAD2L2	ENSLACP00000019203	ENSLACP00000021795	ATPase family AAA domain containing 5.	Mitotic arrest deficient 2 like 2.	0.687
ATAD5	MEIOB	ENSLACP00000019203	ENSLACP00000023109	ATPase family AAA domain containing 5.	Meiosis specific with OB-fold.	0.692
ATAD5	PCNA	ENSLACP00000019203	ENSLACP00000006575	ATPase family AAA domain containing 5.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.981
ATAD5	POLK	ENSLACP00000019203	ENSLACP00000005561	ATPase family AAA domain containing 5.	DNA polymerase kappa.	0.690
ATAD5	REV1	ENSLACP00000019203	ENSLACP00000011946	ATPase family AAA domain containing 5.	DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family.	0.703
ATAD5	REV3L	ENSLACP00000019203	ENSLACP00000009743	ATPase family AAA domain containing 5.	REV3 like, DNA directed polymerase zeta catalytic subunit.	0.726
ATAD5	RFC1	ENSLACP00000019203	ENSLACP00000003355	ATPase family AAA domain containing 5.	Replication factor C subunit 1.	0.716
ATAD5	RFC2	ENSLACP00000019203	ENSLACP00000021161	ATPase family AAA domain containing 5.	Replication factor C subunit 2.	0.985
ATAD5	RFC3	ENSLACP00000019203	ENSLACP00000011255	ATPase family AAA domain containing 5.	Replication factor C subunit 3.	0.992
ATAD5	RFC4	ENSLACP00000019203	ENSLACP00000020302	ATPase family AAA domain containing 5.	Replication factor C subunit 4.	0.991
ATAD5	RFC5	ENSLACP00000019203	ENSLACP00000019284	ATPase family AAA domain containing 5.	Replication factor C subunit 5.	0.989
ATAD5	RPA1	ENSLACP00000019203	ENSLACP00000008142	ATPase family AAA domain containing 5.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.705
ATAD5	RPA3	ENSLACP00000019203	ENSLACP00000010252	ATPase family AAA domain containing 5.	Replication protein A3.	0.641
ATAD5	RPS27A	ENSLACP00000019203	ENSLACP00000008678	ATPase family AAA domain containing 5.	Ribosomal protein S27a.	0.554
H3ANK2_LATCH	ATAD5	ENSLACP00000011223	ENSLACP00000019203	DNA_pol_B_exo1 domain-containing protein.	ATPase family AAA domain containing 5.	0.726
H3ANK2_LATCH	KXD1	ENSLACP00000011223	ENSLACP00000009213	DNA_pol_B_exo1 domain-containing protein.	Ubiquitin-like domain-containing protein.	0.557
H3ANK2_LATCH	LOC102350907	ENSLACP00000011223	ENSLACP00000003879	DNA_pol_B_exo1 domain-containing protein.	Ubiquitin A-52 residue ribosomal protein fusion product 1.	0.557
H3ANK2_LATCH	MAD2L2	ENSLACP00000011223	ENSLACP00000021795	DNA_pol_B_exo1 domain-containing protein.	Mitotic arrest deficient 2 like 2.	0.974