(35 nodes) Termination of translesion DNA synthesis network (Latimeria chalumnae)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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Predicted Interactions

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Your Input:
	RPS27A	Ribosomal protein S27a. (156 aa)
	USP10	Ubiquitin carboxyl-terminal hydrolase. (752 aa)
	KXD1	Ubiquitin-like domain-containing protein. (231 aa)
	RPA3	Replication protein A3. (121 aa)
	POLE2	DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (531 aa)
	RNF135	Uncharacterized protein. (548 aa)
	ATAD5	ATPase family AAA domain containing 5. (1828 aa)
	RFC5	Replication factor C subunit 5. (333 aa)
	POLE	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2289 aa)
	POLE4	DNA polymerase epsilon 4, accessory subunit. (133 aa)
	RFC4	Replication factor C subunit 4. (360 aa)
	RFC2	Replication factor C subunit 2. (396 aa)
	LOC102354416	Uncharacterized protein. (160 aa)
	POLE3	Polymerase (DNA directed), epsilon 3 (p17 subunit). (170 aa)
	MEIOB	Meiosis specific with OB-fold. (470 aa)
	POLI	DNA polymerase iota. (740 aa)
	LOC102351730	RING-type domain-containing protein. (353 aa)
	RFC1	Replication factor C subunit 1. (1152 aa)
	LOC102346166	Ubiquitin-like domain-containing protein. (95 aa)
	LOC102350907	Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa)
	RCBTB2	RCC1 and BTB domain containing protein 2. (413 aa)
	POLK	DNA polymerase kappa. (873 aa)
	TRIM25	Tripartite motif containing 25. (657 aa)
	PCLAF	PCNA clamp associated factor. (122 aa)
	PCNA	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa)
	RPA1	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (495 aa)
	POLD3	Uncharacterized protein. (373 aa)
	RFC3	Replication factor C subunit 3. (237 aa)
	USP31	Ubiquitin specific peptidase 31; Belongs to the peptidase C19 family. (1360 aa)
	REV1	DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family. (1270 aa)
	RCBTB1	RCC1 and BTB domain containing protein 1. (531 aa)
	POLD4	Uncharacterized protein. (122 aa)
	POLH	DNA polymerase eta. (729 aa)
	POLD2	DNA polymerase delta 2, accessory subunit. (469 aa)
	POLD1	DNA polymerase. (1103 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATAD5	LOC102346166	ENSLACP00000019203	ENSLACP00000003410	ATPase family AAA domain containing 5.	Ubiquitin-like domain-containing protein.	0.554
ATAD5	LOC102354416	ENSLACP00000019203	ENSLACP00000022259	ATPase family AAA domain containing 5.	Uncharacterized protein.	0.475
ATAD5	MEIOB	ENSLACP00000019203	ENSLACP00000023109	ATPase family AAA domain containing 5.	Meiosis specific with OB-fold.	0.692
ATAD5	PCLAF	ENSLACP00000019203	ENSLACP00000017740	ATPase family AAA domain containing 5.	PCNA clamp associated factor.	0.541
ATAD5	PCNA	ENSLACP00000019203	ENSLACP00000006575	ATPase family AAA domain containing 5.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.981
ATAD5	POLD1	ENSLACP00000019203	ENSLACP00000017387	ATPase family AAA domain containing 5.	DNA polymerase.	0.846
ATAD5	POLD2	ENSLACP00000019203	ENSLACP00000015422	ATPase family AAA domain containing 5.	DNA polymerase delta 2, accessory subunit.	0.730
ATAD5	POLD3	ENSLACP00000019203	ENSLACP00000010474	ATPase family AAA domain containing 5.	Uncharacterized protein.	0.661
ATAD5	POLD4	ENSLACP00000019203	ENSLACP00000012312	ATPase family AAA domain containing 5.	Uncharacterized protein.	0.457
ATAD5	POLE	ENSLACP00000019203	ENSLACP00000019593	ATPase family AAA domain containing 5.	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family.	0.905
ATAD5	POLE2	ENSLACP00000019203	ENSLACP00000018203	ATPase family AAA domain containing 5.	DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family.	0.860
ATAD5	POLE3	ENSLACP00000019203	ENSLACP00000022736	ATPase family AAA domain containing 5.	Polymerase (DNA directed), epsilon 3 (p17 subunit).	0.796
ATAD5	POLE4	ENSLACP00000019203	ENSLACP00000019883	ATPase family AAA domain containing 5.	DNA polymerase epsilon 4, accessory subunit.	0.759
ATAD5	POLH	ENSLACP00000019203	ENSLACP00000012984	ATPase family AAA domain containing 5.	DNA polymerase eta.	0.682
ATAD5	POLI	ENSLACP00000019203	ENSLACP00000017904	ATPase family AAA domain containing 5.	DNA polymerase iota.	0.639
ATAD5	POLK	ENSLACP00000019203	ENSLACP00000005561	ATPase family AAA domain containing 5.	DNA polymerase kappa.	0.690
ATAD5	REV1	ENSLACP00000019203	ENSLACP00000011946	ATPase family AAA domain containing 5.	DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family.	0.703
ATAD5	RFC1	ENSLACP00000019203	ENSLACP00000003355	ATPase family AAA domain containing 5.	Replication factor C subunit 1.	0.716
ATAD5	RFC2	ENSLACP00000019203	ENSLACP00000021161	ATPase family AAA domain containing 5.	Replication factor C subunit 2.	0.985
ATAD5	RFC3	ENSLACP00000019203	ENSLACP00000011255	ATPase family AAA domain containing 5.	Replication factor C subunit 3.	0.992