Your Input: | |
| | TDP1 | Tyrosyl-DNA phosphodiesterase 1. (614 aa) |
| | M3XL87_LATCH | Uncharacterized protein. (157 aa) |
| | M3XL57_LATCH | Reverse transcriptase domain-containing protein. (332 aa) |
| | MEIOB | Meiosis specific with OB-fold. (470 aa) |
| | M3XK14_LATCH | Uncharacterized protein. (196 aa) |
| | M3XK07_LATCH | Uncharacterized protein. (251 aa) |
| | LOC102365863 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (158 aa) |
| | POLE3 | Polymerase (DNA directed), epsilon 3 (p17 subunit). (170 aa) |
| | EME1 | Essential meiotic structure-specific endonuclease 1. (609 aa) |
| | BARD1 | BRCA1 associated RING domain 1. (866 aa) |
| | RHNO1 | RAD9-HUS1-RAD1 interacting nuclear orphan 1. (319 aa) |
| | RAD9B | Cell cycle checkpoint control protein; Belongs to the rad9 family. (411 aa) |
| | M3XGI0_LATCH | Uncharacterized protein. (117 aa) |
| | TIMELESS | Timeless circadian regulator. (1272 aa) |
| | CDK2 | Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (298 aa) |
| | ATRIP | ATR interacting protein. (782 aa) |
| | EXD2 | Exonuclease 3'-5' domain containing 2. (617 aa) |
| | RFC2 | Replication factor C subunit 2. (396 aa) |
| | BAP1 | BRCA1 associated protein 1. (721 aa) |
| | RAD52 | RAD52 homolog, DNA repair protein. (389 aa) |
| | RAD51AP1 | RAD51 associated protein 1. (341 aa) |
| | UBXN1 | UBX domain protein 1. (320 aa) |
| | RFC4 | Replication factor C subunit 4. (360 aa) |
| | RBBP8 | RB binding protein 8, endonuclease. (906 aa) |
| | H3BDB3_LATCH | Uncharacterized protein. (402 aa) |
| | POLE4 | DNA polymerase epsilon 4, accessory subunit. (133 aa) |
| | RAD51B | RAD51 paralog B. (250 aa) |
| | PARP3 | Poly [ADP-ribose] polymerase. (525 aa) |
| | POLE | DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2289 aa) |
| | RAD51 | DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (341 aa) |
| | EXO1 | Exonuclease 1. (805 aa) |
| | RFC5 | Replication factor C subunit 5. (333 aa) |
| | H3BAV2_LATCH | Uncharacterized protein. (105 aa) |
| | CHEK1 | Checkpoint kinase 1; Belongs to the protein kinase superfamily. (475 aa) |
| | POLE2 | DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (531 aa) |
| | SLC23A3 | Solute carrier family 23 member 3. (584 aa) |
| | CNPPD1 | Cyclin Pas1/PHO80 domain containing 1. (454 aa) |
| | SLF1 | SMC5-SMC6 complex localization factor 1. (1063 aa) |
| | EYA1 | Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (646 aa) |
| | POLD1 | DNA polymerase. (1103 aa) |
| | SPIDR | DUF4503 domain-containing protein. (397 aa) |
| | BRCC3 | BRCA1/BRCA2-containing complex subunit 3. (291 aa) |
| | GEN1 | GEN1 Holliday junction 5' flap endonuclease. (899 aa) |
| | KPNA2 | Importin subunit alpha; Belongs to the importin alpha family. (517 aa) |
| | LOC102350007 | Small ubiquitin-related modifier. (100 aa) |
| | PRKDC | Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4083 aa) |
| | TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (401 aa) |
| | H3B1Z1_LATCH | Uncharacterized protein. (352 aa) |
| | DNA2 | DNA replication helicase/nuclease 2. (925 aa) |
| | PPP4R2 | Protein phosphatase 4, regulatory subunit 2b. (410 aa) |
| | POLD2 | DNA polymerase delta 2, accessory subunit. (469 aa) |
| | KPNA7 | Importin subunit alpha; Belongs to the importin alpha family. (521 aa) |
| | SLX4 | BTB domain-containing protein. (1393 aa) |
| | EME2 | Essential meiotic structure-specific endonuclease subunit 2. (299 aa) |
| | H3AZT0_LATCH | Uncharacterized protein. (114 aa) |
| | H3AYY3_LATCH | Uncharacterized protein. (223 aa) |
| | APBB2 | Amyloid beta precursor protein binding family B member 2. (745 aa) |
| | MUS81 | Uncharacterized protein. (421 aa) |
| | H3AWE1_LATCH | Uncharacterized protein. (135 aa) |
| | XRCC4 | X-ray repair cross complementing 4. (331 aa) |
| | PWWP2A | PWWP domain containing 2A. (843 aa) |
| | ABRAXAS1 | Abraxas 1, BRCA1 A complex subunit. (412 aa) |
| | POLH | DNA polymerase eta. (729 aa) |
| | TMEM182 | Transmembrane protein 182. (242 aa) |
| | PIAS4 | Protein inhibitor of activated STAT 4. (370 aa) |
| | POLD4 | Uncharacterized protein. (122 aa) |
| | NSD2 | Nuclear receptor binding SET domain protein 2. (1348 aa) |
| | RCBTB1 | RCC1 and BTB domain containing protein 1. (531 aa) |
| | XRCC6 | X-ray repair cross complementing 6. (610 aa) |
| | RAD17 | RAD17 checkpoint clamp loader component. (748 aa) |
| | H2BE1 | Histone H2B; Belongs to the histone H2B family. (122 aa) |
| | H3APN8_LATCH | Reverse transcriptase domain-containing protein. (202 aa) |
| | ANKRD11 | Ankyrin repeat domain 11. (2717 aa) |
| | RFC3 | Replication factor C subunit 3. (237 aa) |
| | ATR | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2654 aa) |
| | LOC102360939 | XRCC1_N domain-containing protein. (206 aa) |
| | BABAM1 | BRISC and BRCA1 A complex member 1. (323 aa) |
| | RAD9A | Uncharacterized protein. (273 aa) |
| | H3ALL9_LATCH | Uncharacterized protein. (251 aa) |
| | POLD3 | Uncharacterized protein. (373 aa) |
| | RPA3 | Replication protein A3. (121 aa) |
| | H3AKN8_LATCH | Uncharacterized protein. (129 aa) |
| | SIRT7 | Sirtuin 7. (413 aa) |
| | TOP3A | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (999 aa) |
| | TDP2 | Tyrosyl-DNA phosphodiesterase 2. (366 aa) |
| | H3AK44_LATCH | Histone domain-containing protein; Belongs to the histone H2B family. (105 aa) |
| | XRCC3 | DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (358 aa) |
| | TP53BP1 | Tumor protein p53 binding protein 1. (2149 aa) |
| | H3AIY4_LATCH | Uncharacterized protein. (161 aa) |
| | NBN | Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (772 aa) |
| | LOC102367082 | XPGI domain-containing protein. (317 aa) |
| | KXD1 | Ubiquitin-like domain-containing protein. (231 aa) |
| | TIPIN | TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (293 aa) |
| | SIRT6 | Sirtuin 6. (375 aa) |
| | H3AGP4_LATCH | Tower domain-containing protein. (1245 aa) |
| | LOC102358613 | Uncharacterized protein. (249 aa) |
| | LOC102367189 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (342 aa) |
| | LOC102347040 | Ubiquitin-conjugating enzyme E2Ia; Belongs to the ubiquitin-conjugating enzyme family. (158 aa) |
| | RPS27A | Ribosomal protein S27a. (156 aa) |
| | H3AFK9_LATCH | RING-type domain-containing protein. (482 aa) |
| | CCNA1 | Cyclin A1; Belongs to the cyclin family. (433 aa) |
| | H3AF58_LATCH | Uncharacterized protein. (251 aa) |
| | UBE2N | Ubiquitin-conjugating enzyme E2Na; Belongs to the ubiquitin-conjugating enzyme family. (159 aa) |
| | UIMC1 | Ubiquitin interaction motif containing 1. (735 aa) |
| | H3AEU7_LATCH | Uncharacterized protein. (261 aa) |
| | RPA1 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (495 aa) |
| | H3AE13_LATCH | Uncharacterized protein. (380 aa) |
| | RAD1 | RAD1 checkpoint DNA exonuclease. (281 aa) |
| | PPP4C | Serine/threonine-protein phosphatase. (224 aa) |
| | RMI2 | RecQ mediated genome instability 2. (158 aa) |
| | BLM | BLM RecQ like helicase. (1450 aa) |
| | H3AC16_LATCH | X-ray repair complementing defective repair in Chinese hamster cells 1. (649 aa) |
| | H3ABS6_LATCH | Uncharacterized protein. (443 aa) |
| | RNF8 | E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (542 aa) |
| | H3ABB9_LATCH | WW domain-containing protein. (127 aa) |
| | XRCC5 | X-ray repair cross complementing 5. (606 aa) |
| | HUS1 | Checkpoint protein; Belongs to the HUS1 family. (225 aa) |
| | BRCA1 | BRCA1 DNA repair associated. (1873 aa) |
| | PCNA | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa) |
| | PAXIP1 | PAX interacting protein 1. (1219 aa) |
| | LOC102355250 | Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. (264 aa) |
| | NHEJ1 | Uncharacterized protein. (303 aa) |
| | TOPBP1 | DNA topoisomerase II binding protein 1. (1542 aa) |
| | RIF1 | Replication timing regulatory factor 1. (2351 aa) |
| | RMI1 | RecQ mediated genome instability 1. (616 aa) |
| | H3A8P8_LATCH | DUF4502 domain-containing protein. (165 aa) |
| | H3A8A9_LATCH | Uncharacterized protein. (271 aa) |
| | POLK | DNA polymerase kappa. (873 aa) |
| | EYA3 | Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (593 aa) |
| | ANKRD12 | Ankyrin repeat domain 12. (2105 aa) |
| | ATM | ATM serine/threonine kinase. (2375 aa) |
| | H3A5V3_LATCH | RecQ helicase-like 4. (1456 aa) |
| | H4C11 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa) |
| | H3A5E7_LATCH | Histone H2B; Belongs to the histone H2B family. (130 aa) |
| | APBB1 | Uncharacterized protein. (241 aa) |
| | H3A560_LATCH | RAD50 homolog, double strand break repair protein. (1193 aa) |
| | MRE11 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (710 aa) |
| | PARP2 | Poly [ADP-ribose] polymerase. (502 aa) |
| | RCBTB2 | RCC1 and BTB domain containing protein 2. (413 aa) |
| | H3A4B2_LATCH | Reverse transcriptase domain-containing protein. (787 aa) |
| | EYA4 | Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (620 aa) |
| | LOC102361505 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | H3A427_LATCH | Histone H2B; Belongs to the histone H2B family. (137 aa) |
| | H3A2S8_LATCH | Histone H2B; Belongs to the histone H2B family. (138 aa) |
| | LOC102350907 | Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa) |
| | XRCC2 | X-ray repair cross complementing 2. (282 aa) |
| | LIG4 | DNA ligase. (911 aa) |
| | LOC102346166 | Ubiquitin-like domain-containing protein. (95 aa) |
| | RFC1 | Replication factor C subunit 1. (1152 aa) |
| | PARP1 | Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1011 aa) |
| | RNF169 | Ring finger protein 169. (684 aa) |
| | CDCA7 | Cell division cycle associated 7. (405 aa) |
| | H2ZZP4_LATCH | Histone H2B; Belongs to the histone H2B family. (138 aa) |
| | EYA2 | Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (579 aa) |
| | UBE2V2 | Ubiquitin conjugating enzyme E2 V2. (55 aa) |
| | H2ZXR2_LATCH | Ligase III, DNA, ATP-dependent; Belongs to the ATP-dependent DNA ligase family. (960 aa) |
| | DNTT | DNA-directed DNA/RNA polymerase mu; Gap-filling polymerase involved in repair of DNA double- strand breaks by non-homologous end joining (NHEJ). Belongs to the DNA polymerase type-X family. (487 aa) |
| | PALB2 | PALB2_WD40 domain-containing protein. (874 aa) |
| | H2ZWI5_LATCH | Uncharacterized protein. (1469 aa) |
| | FEN1 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (317 aa) |
| | TDRD3 | Tudor domain containing 3. (746 aa) |
| | H2ZVL4_LATCH | Histone domain-containing protein; Belongs to the histone H2B family. (90 aa) |
| | POLL | DNA polymerase lambda; Belongs to the DNA polymerase type-X family. (572 aa) |
| | CCNA2 | Cyclin A2; Belongs to the cyclin family. (447 aa) |
| | H2ZTC3_LATCH | PARP-type domain-containing protein. (108 aa) |
| | H2ZS42_LATCH | AAA_23 domain-containing protein. (88 aa) |
| | H2ZS39_LATCH | Histone H2B; Belongs to the histone H2B family. (135 aa) |
| | RAD51C | RAD51 paralog C. (368 aa) |
| | DCLRE1C | DNA cross-link repair 1C. (539 aa) |
| | CHEK2 | Checkpoint kinase 2. (411 aa) |
